Corticosteroid 11-beta-dehydrogenase isozyme 1
Details
- Name
- Corticosteroid 11-beta-dehydrogenase isozyme 1
- Synonyms
- 1.1.1.146
- 11-beta-HSD1
- 11-beta-hydroxysteroid dehydrogenase 1
- 11-DH
- HSD11
- HSD11L
- SDR26C1
- Short chain dehydrogenase/reductase family 26C member 1
- Gene Name
- HSD11B1
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0010089|Corticosteroid 11-beta-dehydrogenase isozyme 1 MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAH VVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNH ITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMV AAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEE CALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILEFLYSTSYNMDRFINK
- Number of residues
- 292
- Molecular Weight
- 32400.665
- Theoretical pI
- 8.77
- GO Classification
- Functions11-beta-hydroxysteroid dehydrogenase (NADP+) activity / 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activityProcessesglucocorticoid biosynthetic process / lung development / small molecule metabolic process / steroid metabolic processComponentsendoplasmic reticulum membrane / integral component of membrane / membrane
- General Function
- 11-beta-hydroxysteroid dehydrogenase [nad(p)] activity
- Specific Function
- Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7-ketocholesterol to 7-beta-hydroxycholesterol (By similarity).
- Pfam Domain Function
- adh_short (PF00106)
- Transmembrane Regions
- 8-24
- Cellular Location
- Endoplasmic reticulum membrane
- Gene sequence
>lcl|BSEQ0010090|Corticosteroid 11-beta-dehydrogenase isozyme 1 (HSD11B1) ATGGCTTTTATGAAAAAATATCTCCTCCCCATTCTGGGGCTCTTCATGGCCTACTACTAC TATTCTGCAAACGAGGAATTCAGACCAGAGATGCTCCAAGGAAAGAAAGTGATTGTCACA GGGGCCAGCAAAGGGATCGGAAGAGAGATGGCTTATCATCTGGCGAAGATGGGAGCCCAT GTGGTGGTGACAGCGAGGTCAAAAGAAACTCTACAGAAGGTGGTATCCCACTGCCTGGAG CTTGGAGCAGCCTCAGCACACTACATTGCTGGCACCATGGAAGACATGACCTTCGCAGAG CAATTTGTTGCCCAAGCAGGAAAGCTCATGGGAGGACTAGACATGCTCATTCTCAACCAC ATCACCAACACTTCTTTGAATCTTTTTCATGATGATATTCACCATGTGCGCAAAAGCATG GAAGTCAACTTCCTCAGTTACGTGGTCCTGACTGTAGCTGCCTTGCCCATGCTGAAGCAG AGCAATGGAAGCATTGTTGTCGTCTCCTCTCTGGCTGGGAAAGTGGCTTATCCAATGGTT GCTGCCTATTCTGCAAGCAAGTTTGCTTTGGATGGGTTCTTCTCCTCCATCAGAAAGGAA TATTCAGTGTCCAGGGTCAATGTATCAATCACTCTCTGTGTTCTTGGCCTCATAGACACA GAAACAGCCATGAAGGCAGTTTCTGGGATAGTCCATATGCAAGCAGCTCCAAAGGAGGAA TGTGCCCTGGAGATCATCAAAGGGGGAGCTCTGCGCCAAGAAGAAGTGTATTATGACAGC TCACTCTGGACCACTCTTCTGATCAGAAATCCATGCAGGAAGATCCTGGAATTTCTCTAC TCAACGAGCTATAATATGGACAGATTCATAAACAAGTAG
- Chromosome Location
- 1
- Locus
- 1q32-q41
- External Identifiers
Resource Link UniProtKB ID P28845 UniProtKB Entry Name DHI1_HUMAN GenBank Protein ID 179475 GenBank Gene ID M76665 GenAtlas ID HSD11B1 HGNC ID HGNC:5208 - General References
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Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB00157 NADH approved, nutraceutical unknown Details DB02329 Carbenoxolone experimental unknown inhibitor Details DB03461 Nicotinamide adenine dinucleotide phosphate experimental unknown Details DB03814 2-(N-morpholino)ethanesulfonic acid experimental unknown Details DB05064 INCB13739 investigational unknown Details DB06992 (3,3-dimethylpiperidin-1-yl)(6-(3-fluoro-4-methylphenyl)pyridin-2-yl)methanone experimental unknown Details DB07017 (5S)-2-{[(1S)-1-(4-Fluorophenyl)ethyl]amino}-5-(2-hydroxy-2-propanyl)-5-methyl-1,3-thiazol-4(5H)-one experimental unknown Details DB07049 (2R)-1-[(4-tert-butylphenyl)sulfonyl]-2-methyl-4-(4-nitrophenyl)piperazine experimental unknown Details DB07056 2-(6-{[(3-chloro-2-methylphenyl)sulfonyl]amino}pyridin-2-yl)-N,N-diethylacetamide experimental unknown Details DB07310 (5S)-2-{[(1S)-1-(2-fluorophenyl)ethyl]amino}-5-methyl-5-(trifluoromethyl)-1,3-thiazol-4(5H)-one experimental unknown Details DB07316 N-{1-[(1-carbamoylcyclopropyl)methyl]piperidin-4-yl}-N-cyclopropyl-4-[(1S)-2,2,2-trifluoro-1-hydroxy-1-methylethyl]benzamide experimental unknown Details DB04652 Corticosterone experimental yes substrateproduct of Details DB07619 N-cyclopropyl-N-(trans-4-pyridin-3-ylcyclohexyl)-4-[(1S)-2,2,2-trifluoro-1-hydroxy-1-methylethyl]benzamide experimental unknown Details DB07624 1-{[(3R)-3-methyl-4-({4-[(1S)-2,2,2-trifluoro-1-hydroxy-1-methylethyl]phenyl}sulfonyl)piperazin-1-yl]methyl}cyclopropanecarboxamide experimental unknown Details DB07866 (5S)-2-(Cyclooctylamino)-5-methyl-5-propyl-1,3-thiazol-4(5H)-one experimental unknown Details DB08277 2-(2-CHLORO-4-FLUOROPHENOXY)-2-METHYL-N-[(1R,2S,3S,5S,7S)-5-(METHYLSULFONYL)-2-ADAMANTYL]PROPANAMIDE experimental unknown Details DB08280 (1S,3R,4S,5S,7S)-4-{[2-(4-METHOXYPHENOXY)-2-METHYLPROPANOYL]AMINO}ADAMANTANE-1-CARBOXAMIDE experimental unknown Details DB08771 (5R)-2-[(2-Fluorophenyl)amino]-5-isopropyl-1,3-thiazol-4(5H)-one experimental unknown Details DB13751 Glycyrrhizic acid approved, experimental yes antagonist Details DB00461 Nabumetone approved unknown substrate Details DB00687 Fludrocortisone approved, investigational unknown substrate Details DB00635 Prednisone approved, vet_approved unknown substrate Details DB00741 Hydrocortisone approved, vet_approved unknown substrate Details DB01234 Dexamethasone approved, investigational, vet_approved unknown substrate Details DB14631 Prednisolone phosphate approved, vet_approved unknown substrate Details DB14649 Dexamethasone acetate approved, investigational, vet_approved unknown substrate Details DB15093 Somapacitan approved, investigational unknown inhibitor Details DB16220 Lonapegsomatropin approved, investigational unknown inhibitor Details DB04652 Corticosterone experimental no substrateproduct of Details DB00959 Methylprednisolone approved, vet_approved unknown Details