Inositol monophosphatase 1
Details
- Name
- Inositol monophosphatase 1
- Synonyms
- 3.1.3.25
- D-galactose 1-phosphate phosphatase
- IMP 1
- IMPA
- Inositol-1(or 4)-monophosphatase 1
- Lithium-sensitive myo-inositol monophosphatase A1
- Gene Name
- IMPA1
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0002291|Inositol monophosphatase 1 MADPWQECMDYAVTLARQAGEVVCEAIKNEMNVMLKSSPVDLVTATDQKVEKMLISSIKE KYPSHSFIGEESVAAGEKSILTDNPTWIIDPIDGTTNFVHRFPFVAVSIGFAVNKKIEFG VVYSCVEGKMYTARKGKGAFCNGQKLQVSQQEDITKSLLVTELGSSRTPETVRMVLSNME KLFCIPVHGIRSVGTAAVNMCLVATGGADAYYEMGIHCWDVAGAGIIVTEAGGVLMDVTG GPFDLMSRRVIAANNRILAERIAKEIQVIPLQRDDED
- Number of residues
- 277
- Molecular Weight
- 30188.59
- Theoretical pI
- 4.91
- GO Classification
- Functionsidentical protein binding / inositol monophosphate 1-phosphatase activity / inositol monophosphate 3-phosphatase activity / inositol monophosphate 4-phosphatase activity / inositol monophosphate phosphatase activity / lithium ion binding / magnesium ion binding / manganese ion binding / protein homodimerization activityProcessesinositol biosynthetic process / inositol metabolic process / inositol phosphate dephosphorylation / inositol phosphate metabolic process / phosphate-containing compound metabolic process / phosphatidylinositol biosynthetic process / phosphatidylinositol phosphorylation / signal transduction / small molecule metabolic processComponentscytoplasm / cytosol / extracellular exosome
- General Function
- Protein homodimerization activity
- Specific Function
- Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and has been implicated as the pharmacological target for lithium action in brain. Has broad substrate specificity and can use myo-inositol monophosphates, myo-inositol 1,3-diphosphate, myo-inositol 1,4-diphosphate, scyllo-inositol-phosphate, D-galactose 1-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates.
- Pfam Domain Function
- Inositol_P (PF00459)
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0010804|Inositol monophosphatase 1 (IMPA1) ATGGGGCAGCGCCCAGGTCCTGTGCTGCCCGCAGTCGCGGTGCTGGGACAGGTGGCAAAA AGGAAGGTGGCCTGGCTCCTACGCTGGAAGGCTGTGACCAGGACAGAAACAGCAGGAAAC AGTTCAGGTGTTTATGGCTTTGGGAAAATGAAAATATTTGTCAAATATTTTCAGAAGATG GCTGATCCTTGGCAGGAATGCATGGATTATGCAGTAACTCTAGCAAGACAAGCTGGAGAG GTAGTTTGTGAAGCTATAAAAAATGAAATGAATGTTATGCTGAAAAGTTCTCCAGTTGAT TTGGTAACTGCTACGGACCAAAAAGTTGAAAAAATGCTTATCTCTTCCATAAAGGAAAAG TATCCATCTCACAGTTTCATTGGTGAAGAATCTGTGGCAGCTGGGGAAAAAAGTATCTTA ACCGACAACCCCACATGGATCATTGACCCTATTGATGGAACAACTAACTTTGTACATAGA TTTCCTTTTGTAGCTGTTTCAATTGGCTTTGCTGTAAATAAAAAGATAGAATTTGGAGTT GTGTACAGTTGTGTGGAAGGCAAGATGTACACTGCCAGAAAAGGAAAAGGTGCCTTTTGT AATGGTCAAAAACTACAAGTTTCACAACAAGAAGATATTACCAAATCTCTCTTGGTGACT GAGTTGGGCTCTTCCAGAACACCAGAGACTGTGAGAATGGTTCTTTCTAATATGGAAAAG CTTTTTTGCATTCCTGTTCATGGGATCCGGAGTGTTGGAACAGCAGCTGTTAATATGTGC CTTGTGGCAACTGGCGGAGCAGATGCATATTATGAAATGGGAATTCACTGCTGGGATGTT GCAGGAGCTGGCATTATTGTTACTGAAGCTGGTGGCGTGCTAATGGATGTTACAGGTGGA CCATTTGATTTGATGTCACGAAGAGTAATTGCTGCAAATAATAGAATATTAGCAGAAAGG ATAGCTAAAGAAATTCAGGTTATACCTTTGCAACGAGACGACGAAGATTAA
- Chromosome Location
- 8
- Locus
- 8q21.13-q21.3
- External Identifiers
Resource Link UniProtKB ID P29218 UniProtKB Entry Name IMPA1_HUMAN GenBank Protein ID 395340 GenBank Gene ID X66922 GenAtlas ID IMPA1 HGNC ID HGNC:6050 - General References
- McAllister G, Whiting P, Hammond EA, Knowles MR, Atack JR, Bailey FJ, Maigetter R, Ragan CI: cDNA cloning of human and rat brain myo-inositol monophosphatase. Expression and characterization of the human recombinant enzyme. Biochem J. 1992 Jun 15;284 ( Pt 3):749-54. [Article]
- Sjoholt G, Molven A, Lovlie R, Wilcox A, Sikela JM, Steen VM: Genomic structure and chromosomal localization of a human myo-inositol monophosphatase gene (IMPA). Genomics. 1997 Oct 1;45(1):113-22. [Article]
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- Parthasarathy R, Parthasarathy L, Vadnal R: Brain inositol monophosphatase identified as a galactose 1-phosphatase. Brain Res. 1997 Dec 5;778(1):99-106. [Article]
- Ohnishi T, Ohba H, Seo KC, Im J, Sato Y, Iwayama Y, Furuichi T, Chung SK, Yoshikawa T: Spatial expression patterns and biochemical properties distinguish a second myo-inositol monophosphatase IMPA2 from IMPA1. J Biol Chem. 2007 Jan 5;282(1):637-46. Epub 2006 Oct 26. [Article]
- Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP: A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10762-7. doi: 10.1073/pnas.0805139105. Epub 2008 Jul 31. [Article]
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- Bone R, Springer JP, Atack JR: Structure of inositol monophosphatase, the putative target of lithium therapy. Proc Natl Acad Sci U S A. 1992 Nov 1;89(21):10031-5. [Article]
- Bone R, Frank L, Springer JP, Pollack SJ, Osborne SA, Atack JR, Knowles MR, McAllister G, Ragan CI, Broughton HB, et al.: Structural analysis of inositol monophosphatase complexes with substrates. Biochemistry. 1994 Aug 16;33(32):9460-7. [Article]
- Bone R, Frank L, Springer JP, Atack JR: Structural studies of metal binding by inositol monophosphatase: evidence for two-metal ion catalysis. Biochemistry. 1994 Aug 16;33(32):9468-76. [Article]
- Ganzhorn AJ, Lepage P, Pelton PD, Strasser F, Vincendon P, Rondeau JM: The contribution of lysine-36 to catalysis by human myo-inositol monophosphatase. Biochemistry. 1996 Aug 20;35(33):10957-66. [Article]
- Singh N, Halliday AC, Knight M, Lack NA, Lowe E, Churchill GC: Cloning, expression, purification, crystallization and X-ray analysis of inositol monophosphatase from Mus musculus and Homo sapiens. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Oct 1;68(Pt 10):1149-52. doi: 10.1107/S1744309112035191. Epub 2012 Sep 22. [Article]
Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB01356 Lithium cation experimental unknown inhibitor Details DB03542 L-Myo-Inositol-1-Phosphate experimental unknown Details DB14507 Lithium citrate approved unknown Details DB14508 Lithium succinate experimental unknown Details DB14509 Lithium carbonate approved unknown Details