Flavin reductase (NADPH)
Details
- Name
- Flavin reductase (NADPH)
- Synonyms
- 1.5.1.30
- Biliverdin reductase B
- Biliverdin-IX beta-reductase
- BVR-B
- FLR
- FR
- GHBP
- Green heme-binding protein
- NADPH-dependent diaphorase
- NADPH-flavin reductase
- Gene Name
- BLVRB
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0010413|Flavin reductase (NADPH) MAVKKIAIFGATGQTGLTTLAQAVQAGYEVTVLVRDSSRLPSEGPRPAHVVVGDVLQAAD VDKTVAGQDAVIVLLGTRNDLSPTTVMSEGARNIVAAMKAHGVDKVVACTSAFLLWDPTK VPPRLQAVTDDHIRMHKVLRESGLKYVAVMPPHIGDQPLTGAYTVTLDGRGPSRVISKHD LGHFMLRCLTTDEYDGHSTYPSHQYQ
- Number of residues
- 206
- Molecular Weight
- 22119.215
- Theoretical pI
- 7.76
- GO Classification
- Functionsbiliverdin reductase activity / riboflavin reductase (NADPH) activityProcessesheme catabolic process / porphyrin-containing compound metabolic process / small molecule metabolic processComponentscytoplasm / cytosol / extracellular exosome / nucleoplasm / plasma membrane
- General Function
- Riboflavin reductase (nadph) activity
- Specific Function
- Broad specificity oxidoreductase that catalyzes the NADPH-dependent reduction of a variety of flavins, such as riboflavin, FAD or FMN, biliverdins, methemoglobin and PQQ (pyrroloquinoline quinone). Contributes to heme catabolism and metabolizes linear tetrapyrroles. Can also reduce the complexed Fe(3+) iron to Fe(2+) in the presence of FMN and NADPH. In the liver, converts biliverdin to bilirubin.
- Pfam Domain Function
- NAD_binding_10 (PF13460)
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0010414|Flavin reductase (NADPH) (BLVRB) ATGGCCGTCAAGAAGATCGCGATCTTCGGCGCCACTGGCCAGACCGGGCTCACCACCCTG GCGCAGGCGGTGCAAGCAGGTTACGAAGTGACAGTGCTGGTGCGGGACTCCTCCAGGCTG CCATCAGAGGGGCCCCGGCCGGCCCACGTGGTAGTGGGAGATGTTCTGCAGGCAGCCGAT GTGGACAAGACCGTGGCTGGGCAGGACGCTGTCATCGTGCTGCTGGGCACCCGCAATGAC CTCAGTCCCACGACAGTGATGTCCGAGGGCGCCCGGAACATTGTGGCAGCCATGAAGGCT CATGGTGTGGACAAGGTCGTGGCCTGCACCTCGGCTTTCCTGCTCTGGGACCCTACCAAG GTGCCCCCACGACTGCAGGCTGTGACTGATGACCACATCCGGATGCACAAGGTGCTGCGG GAATCAGGCCTGAAGTACGTGGCTGTGATGCCGCCACACATAGGAGACCAGCCACTAACT GGGGCGTACACAGTGACCCTGGATGGACGAGGGCCCTCAAGGGTCATCTCCAAACATGAC CTGGGCCATTTCATGCTGCGCTGCCTCACCACCGATGAGTACGACGGACACAGCACCTAC CCCTCCCACCAGTACCAGTAG
- Chromosome Location
- 19
- Locus
- 19q13.1-q13.2
- External Identifiers
Resource Link UniProtKB ID P30043 UniProtKB Entry Name BLVRB_HUMAN GenBank Protein ID 1384068 GenBank Gene ID D26308 GenAtlas ID BLVRB HGNC ID HGNC:1063 - General References
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Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB00140 Riboflavin approved, investigational, nutraceutical, vet_approved yes product of Details DB00157 NADH approved, nutraceutical unknown Details DB02073 Biliverdine IX Alpha experimental unknown Details DB03247 Flavin mononucleotide approved, investigational unknown Details DB03461 Nicotinamide adenine dinucleotide phosphate experimental unknown Details DB04345 Lumichrome experimental unknown Details DB04363 Mesobiliverdin IV alpha experimental unknown Details DB09241 Methylene blue approved, investigational no substrate Details