UMP-CMP kinase
Details
- Name
- UMP-CMP kinase
- Synonyms
- 2.7.4.14
- CK
- CMK
- CMPK
- dCMP kinase
- Deoxycytidylate kinase
- Nucleoside-diphosphate kinase
- UCK
- UMK
- UMP/CMP kinase
- UMP/CMPK
- UMPK
- Uridine monophosphate/cytidine monophosphate kinase
- Gene Name
- CMPK1
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0001270|UMP-CMP kinase MKPLVVFVLGGPGAGKGTQCARIVEKYGYTHLSAGELLRDERKNPDSQYGELIEKYIKEG KIVPVEITISLLKREMDQTMAANAQKNKFLIDGFPRNQDNLQGWNKTMDGKADVSFVLFF DCNNEICIERCLERGKSSGRSDDNRESLEKRIQTYLQSTKPIIDLYEEMGKVKKIDASKS VDEVFDEVVQIFDKEG
- Number of residues
- 196
- Molecular Weight
- 22222.175
- Theoretical pI
- 5.2
- GO Classification
- FunctionsATP binding / cytidylate kinase activity / nucleoside diphosphate kinase activity / uridine kinase activity / uridylate kinase activityProcesses'de novo' pyrimidine nucleobase biosynthetic process / nucleobase-containing small molecule interconversion / nucleobase-containing small molecule metabolic process / nucleoside diphosphate phosphorylation / nucleoside triphosphate biosynthetic process / pyrimidine ribonucleotide biosynthetic process / small molecule metabolic process / UMP biosynthetic processComponentscytoplasm / cytosol / extracellular exosome / nucleus
- General Function
- Uridylate kinase activity
- Specific Function
- Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity.
- Pfam Domain Function
- ADK (PF00406)
- Transmembrane Regions
- Not Available
- Cellular Location
- Nucleus
- Gene sequence
>lcl|BSEQ0010444|UMP-CMP kinase (CMPK1) ATGCTGAGCCGCTGCCGCAGCGGGCTGCTCCACGTCCTGGGCCTTAGCTTCCTGCTGCAG ACCCGCCGGCCGATTCTCCTCTGCTCTCCACGTCTCATGAAGCCGCTGGTCGTGTTCGTC CTCGGCGGCCCCGGCGCCGGCAAGGGGACCCAGTGCGCCCGCATCGTCGAGGAAATGGAT CAGACAATGGCTGCCAATGCTCAGAAGAATAAATTCTTGATTGATGGGTTTCCAAGAAAT CAAGACAACCTTCAAGGATGGAACAAGACCATGGATGGGAAGGCAGATGTATCTTTCGTT CTCTTTTTTGACTGTAATAATGAGATTTGTATTGAACGATGTCTTGAGAGGGGAAAGAGT AGTGGTAGGAGTGATGACAACAGAGAGAGCTTGGAAAAGAGAATTCAGACCTACCTTCAG TCAACAAAGCCAATTATTGACTTATATGAAGAAATGGGGAAAGTCAAGAAAATAGATGCT TCTAAATCTGTTGATGAAGTTTTTGATGAAGTTGTGCAGATTTTTGACAAGGAAGGCTAA
- Chromosome Location
- 1
- Locus
- 1p32
- External Identifiers
Resource Link UniProtKB ID P30085 UniProtKB Entry Name KCY_HUMAN GenBank Protein ID 6578133 GenBank Gene ID AF070416 GenAtlas ID CMPK HGNC ID HGNC:18170 - General References
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Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB00441 Gemcitabine approved unknown inhibitor Details DB03403 Cytidine-5'-Monophosphate experimental unknown Details DB03435 Uridine-5'-Diphosphate experimental unknown Details DB03664 P1-(adenosine-5'-P5-(uridine-5')pentaphosphate experimental unknown Details DB04444 Tetrafluoroaluminate Ion experimental unknown Details DB00709 Lamivudine approved, investigational unknown substrate Details DB08934 Sofosbuvir approved unknown substrate Details DB01262 Decitabine approved, investigational yes substrate Details DB00441 Gemcitabine approved no substrate Details