Peptidyl-prolyl cis-trans isomerase F, mitochondrial
Details
- Name
- Peptidyl-prolyl cis-trans isomerase F, mitochondrial
- Synonyms
- 5.2.1.8
- Cyclophilin D
- Cyclophilin F
- CyP-D
- CyP-M
- CYP3
- CypD
- Mitochondrial cyclophilin
- PPIase F
- Rotamase F
- Gene Name
- PPIF
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0002777|Peptidyl-prolyl cis-trans isomerase F, mitochondrial MLALRCGSRWLGLLSVPRSVPLRLPAARACSKGSGDPSSSSSSGNPLVYLDVDANGKPLG RVVLELKADVVPKTAENFRALCTGEKGFGYKGSTFHRVIPSFMCQAGDFTNHNGTGGKSI YGSRFPDENFTLKHVGPGVLSMANAGPNTNGSQFFICTIKTDWLDGKHVVFGHVKEGMDV VKKIESFGSKSGRTSKKIVITDCGQLS
- Number of residues
- 207
- Molecular Weight
- 22040.09
- Theoretical pI
- 9.95
- GO Classification
- Functionscyclosporin A binding / peptidyl-prolyl cis-trans isomerase activityProcessesapoptotic mitochondrial changes / cellular response to arsenic-containing substance / cellular response to calcium ion / cellular response to hydrogen peroxide / necroptotic process / negative regulation of apoptotic process / negative regulation of ATPase activity / negative regulation of intrinsic apoptotic signaling pathway / negative regulation of oxidative phosphorylation / negative regulation of oxidative phosphorylation uncoupler activity / negative regulation of release of cytochrome c from mitochondria / positive regulation of release of cytochrome c from mitochondria / protein folding / protein peptidyl-prolyl isomerization / regulation of mitochondrial membrane permeability / regulation of mitochondrial membrane permeability involved in programmed necrotic cell death / regulation of necrotic cell death / regulation of proton-transporting ATPase activity, rotational mechanism / response to ischemiaComponentsmembrane / mitochondrial inner membrane / mitochondrial matrix / mitochondrion
- General Function
- Peptidyl-prolyl cis-trans isomerase activity
- Specific Function
- PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Involved in regulation of the mitochondrial permeability transition pore (mPTP). It is proposed that its association with the mPTP is masking a binding site for inhibiting inorganic phosphate (Pi) and promotes the open probability of the mPTP leading to apoptosis or necrosis; the requirement of the PPIase activity for this function is debated. In cooperation with mitochondrial TP53 is involved in activating oxidative stress-induced necrosis. Involved in modulation of mitochondrial membrane F(1)F(0) ATP synthase activity and regulation of mitochondrial matrix adenine nucleotide levels. Has anti-apoptotic activity independently of mPTP and in cooperation with BCL2 inhibits cytochrome c-dependent apoptosis.
- Pfam Domain Function
- Pro_isomerase (PF00160)
- Transmembrane Regions
- Not Available
- Cellular Location
- Mitochondrion matrix
- Gene sequence
>lcl|BSEQ0021846|Peptidyl-prolyl cis-trans isomerase F, mitochondrial (PPIF) ATGCTGGCGCTGCGCTGCGGCTCCCGCTGGCTCGGCCTGCTCTCCGTCCCGCGCTCCGTG CCGCTGCGCCTCCCCGCGGCCCGCGCCTGCAGCAAGGGCTCCGGCGACCCGTCCTCTTCC TCCTCCTCCGGGAACCCGCTCGTGTACCTGGACGTGGACGCCAACGGGAAGCCGCTCGGC CGCGTGGTGCTGGAGCTGAAGGCAGATGTCGTCCCAAAGACAGCTGAGAACTTCAGAGCC CTGTGCACTGGTGAGAAGGGCTTCGGCTACAAAGGCTCCACCTTCCACAGGGTGATCCCT TCCTTCATGTGCCAGGCGGGCGACTTCACCAACCACAATGGCACAGGCGGGAAGTCCATC TACGGAAGCCGCTTTCCTGACGAGAACTTTACACTGAAGCACGTGGGGCCAGGTGTCCTG TCCATGGCTAATGCTGGTCCTAACACCAACGGCTCCCAGTTCTTCATCTGCACCATAAAG ACAGACTGGTTGGATGGCAAGCATGTTGTGTTCGGTCACGTCAAAGAGGGCATGGACGTC GTGAAGAAAATAGAATCTTTCGGCTCTAAGAGTGGGAGGACATCCAAGAAGATTGTCATC ACAGACTGTGGCCAGTTGAGCTAA
- Chromosome Location
- 10
- Locus
- 10q22-q23
- External Identifiers
Resource Link UniProtKB ID P30405 UniProtKB Entry Name PPIF_HUMAN GenBank Protein ID 181274 GenBank Gene ID M80254 GenAtlas ID PPIF HGNC ID HGNC:9259 - General References
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