Neuronal acetylcholine receptor subunit alpha-3
Details
- Name
- Neuronal acetylcholine receptor subunit alpha-3
- Synonyms
- NACHRA3
- Gene Name
- CHRNA3
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0006903|Neuronal acetylcholine receptor subunit alpha-3 MGSGPLSLPLALSPPRLLLLLLLSLLPVARASEAEHRLFERLFEDYNEIIRPVANVSDPV IIHFEVSMSQLVKVDEVNQIMETNLWLKQIWNDYKLKWNPSDYGGAEFMRVPAQKIWKPD IVLYNNAVGDFQVDDKTKALLKYTGEVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSW SYDKAKIDLVLIGSSMNLKDYWESGEWAIIKAPGYKHDIKYNCCEEIYPDITYSLYIRRL PLFYTINLIIPCLLISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLV IPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPTTHTMPSWVKTVFLNLLPRVMFMTRPT SNEGNAQKPRPLYGAELSNLNCFSRAESKGCKEGYPCQDGMCGYCHHRRIKISNFSANLT RSSSSESVDAVLSLSALSPEIKEAIQSVKYIAENMKAQNEAKEIQDDWKYVAMVIDRIFL WVFTLVCILGTAGLFLQPLMAREDA
- Number of residues
- 505
- Molecular Weight
- 57479.54
- Theoretical pI
- 6.4
- GO Classification
- Functionsacetylcholine binding / acetylcholine receptor activity / acetylcholine-activated cation-selective channel activity / drug binding / ligand-gated ion channel activityProcessesactivation of transmembrane receptor protein tyrosine kinase activity / behavioral response to nicotine / cation transmembrane transport / excitatory postsynaptic potential / heart development / ion transmembrane transport / ion transport / locomotory behavior / nervous system development / neurological system process / protein heterooligomerization / regulation of acetylcholine secretion, neurotransmission / regulation of dendrite morphogenesis / regulation of membrane potential / regulation of smooth muscle contraction / response to drug / response to inorganic substance / signal transduction / synaptic transmission / synaptic transmission involved in micturition / synaptic transmission, cholinergicComponentsacetylcholine-gated channel complex / cell junction / dendrite / integral component of membrane / neuron projection / neuronal cell body / plasma membrane / postsynaptic density / postsynaptic membrane / synapse
- General Function
- Ligand-gated ion channel activity
- Specific Function
- After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
- Pfam Domain Function
- Transmembrane Regions
- 241-265 273-291 307-328 478-497
- Cellular Location
- Cell junction
- Gene sequence
>lcl|BSEQ0012491|Neuronal acetylcholine receptor subunit alpha-3 (CHRNA3) ATGGGCTCTGGCCCGCTCTCGCTGCCCCTGGCGCTGTCGCCGCCGCGGCTGCTGCTGCTG CTGCTGCTGTCTCTGCTGCCAGTGGCCAGGGCCTCAGAGGCTGAGCACCGTCTATTTGAG CGGCTGTTTGAAGATTACAATGAGATCATCCGGCCTGTAGCCAACGTGTCTGACCCAGTC ATCATCCATTTCGAGGTGTCCATGTCTCAGCTGGTGAAGGTGGATGAAGTAAACCAGATC ATGGAGACCAACCTGTGGCTCAAGCAAATCTGGAATGACTACAAGCTGAAATGGAACCCC TCTGACTATGGTGGGGCAGAGTTCATGCGTGTCCCTGCACAGAAGATCTGGAAGCCAGAC ATTGTGCTGTATAACAATGCTGTTGGGGATTTCCAGGTGGACGACAAGACCAAAGCCTTA CTCAAGTACACTGGGGAGGTGACTTGGATACCTCCGGCCATCTTTAAGAGCTCCTGTAAA ATCGACGTGACCTACTTCCCGTTTGATTACCAAAACTGTACCATGAAGTTCGGTTCCTGG TCCTACGATAAGGCGAAAATCGATCTGGTCCTGATCGGCTCTTCCATGAACCTCAAGGAC TATTGGGAGAGCGGCGAGTGGGCCATCATCAAAGCCCCAGGCTACAAACACGACATCAAG TACAACTGCTGCGAGGAGATCTACCCCGACATCACATACTCGCTGTACATCCGGCGCCTG CCCTTGTTCTACACCATCAACCTCATCATCCCCTGCCTGCTCATCTCCTTCCTCACTGTG CTCGTCTTCTACCTGCCCTCCGACTGCGGTGAGAAGGTGACCCTGTGCATTTCTGTCCTC CTCTCCCTGACGGTGTTTCTCCTGGTGATCACTGAGACCATCCCTTCCACCTCGCTGGTC ATCCCCCTGATTGGAGAGTACCTCCTGTTCACCATGATTTTTGTAACCTTGTCCATCGTC ATCACCGTCTTCGTGCTCAACGTGCACTACAGAACCCCGACGACACACACAATGCCCTCA TGGGTGAAGACTGTATTCTTGAACCTGCTCCCCAGGGTCATGTTCATGACCAGGCCAACA AGCAACGAGGGCAACGCTCAGAAGCCGAGGCCCCTCTACGGTGCCGAGCTCTCAAATCTG AATTGCTTCAGCCGCGCAGAGTCCAAAGGCTGCAAGGAGGGCTACCCCTGCCAGGACGGG ATGTGTGGTTACTGCCACCACCGCAGGATAAAAATCTCCAATTTCAGTGCTAACCTCACG AGAAGCTCTAGTTCTGAATCTGTTGATGCTGTGCTGTCCCTCTCTGCTTTGTCACCAGAA ATCAAAGAAGCCATCCAAAGTGTCAAGTATATTGCTGAAAATATGAAAGCACAAAATGAA GCCAAAGAGATTCAAGATGATTGGAAGTATGTTGCCATGGTGATTGATCGTATTTTTCTG TGGGTTTTCACCCTGGTGTGCATTCTAGGGACAGCAGGATTGTTTCTGCAACCCCTGATG GCCAGGGAAGATGCATAA
- Chromosome Location
- 15
- Locus
- 15q24
- External Identifiers
Resource Link UniProtKB ID P32297 UniProtKB Entry Name ACHA3_HUMAN GenBank Protein ID 177898 GenBank Gene ID M86383 HGNC ID HGNC:1957 - General References
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Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB00848 Levamisole approved, investigational, vet_approved, withdrawn yes agonist Details DB00184 Nicotine approved unknown agonist Details DB01227 Levacetylmethadol approved, investigational, withdrawn unknown antagonist Details DB01273 Varenicline approved, investigational unknown partial agonist Details DB01156 Bupropion approved unknown antagonist Details DB01090 Pentolinium approved yes antagonist Details DB00514 Dextromethorphan approved unknown antagonist Details DB09028 Cytisine experimental unknown agonist Details DB00898 Ethanol approved unknown Details DB07720 Epibatidine experimental unknown agonist Details DB05710 Gantacurium investigational yes antagonist Details DB00915 Amantadine approved unknown antagonist Details DB00472 Fluoxetine approved, vet_approved unknown antagonist Details DB00333 Methadone approved unknown antagonist Details DB00237 Butabarbital approved, illicit unknown inhibitor Details DB00202 Succinylcholine approved yes agonist Details DB00565 Cisatracurium approved, investigational yes antagonist Details