Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial
Details
- Name
- Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial
- Synonyms
- 3.6.1.23
- dUTP pyrophosphatase
- dUTPase
- Gene Name
- DUT
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0037138|Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial MTPLCPRPALCYHFLTSLLRSAMQNARGARQRAEAAVLSGPGPPLGRAAQHGIPRPLSSA GRLSQGCRGASTVGAAGWKGELPKAGGSPAPGPETPAISPSKRARPAEVGGMQLRFARLS EHATAPTRGSARAAGYDLYSAYDYTIPPMEKAVVKTDIQIALPSGCYGRVAPRSGLAAKH FIDVGAGVIDEDYRGNVGVVLFNFGKEKFEVKKGDRIAQLICERIFYPEIEEVQALDDTE RGSGGFGSTGKN
- Number of residues
- 252
- Molecular Weight
- 26562.975
- Theoretical pI
- 10.01
- GO Classification
- FunctionsdUTP diphosphatase activity / magnesium ion binding / poly(A) RNA bindingProcessesDNA replication / dUMP biosynthetic process / dUTP catabolic process / nucleobase-containing compound metabolic process / nucleobase-containing small molecule metabolic process / pyrimidine nucleobase metabolic process / pyrimidine nucleoside biosynthetic process / small molecule metabolic processComponentscytoplasm / extracellular exosome / mitochondrion / nucleoplasm / nucleus
- General Function
- Poly(a) rna binding
- Specific Function
- This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
- Pfam Domain Function
- dUTPase (PF00692)
- Transmembrane Regions
- Not Available
- Cellular Location
- Nucleus
- Gene sequence
>lcl|BSEQ0010839|Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial (DUT) ATGACTCCCCTCTGCCCTCGCCCCGCGCTCTGCTACCATTTCCTTACGTCTCTGCTTCGC TCAGCGATGCAAAACGCGCGAGGCGCACGGCAGAGGGCCGAAGCCGCGGTACTCTCCGGG CCAGGCCCGCCCCTCGGCCGCGCCGCGCAGCACGGGATTCCCCGGCCGCTGTCCAGCGCT GGCCGCCTGAGCCAAGGCTGCCGCGGAGCCAGTACAGTCGGGGCCGCTGGCTGGAAGGGC GAGCTTCCTAAGGCGGGGGGAAGCCCGGCGCCGGGGCCGGAGACACCCGCCATTTCACCC AGTAAGCGGGCCCGGCCTGCGGAGGTGGGCGGCATGCAGCTCCGCTTTGCCCGGCTCTCC GAGCACGCCACGGCCCCCACCCGGGGCTCCGCGCGCGCCGCGGGCTACGACCTGTACAGT GCCTATGATTACACAATACCACCTATGGAGAAAGCTGTTGTGAAAACGGACATTCAGATA GCGCTCCCTTCTGGGTGTTATGGAAGAGTGGCTCCACGGTCAGGCTTGGCTGCAAAACAC TTTATTGATGTAGGAGCTGGTGTCATAGATGAAGATTATAGAGGAAATGTTGGTGTTGTA CTGTTTAATTTTGGCAAAGAAAAGTTTGAAGTCAAAAAAGGTGATCGAATTGCACAGCTC ATTTGCGAACGGATTTTTTATCCAGAAATAGAAGAAGTTCAAGCCTTGGATGACACCGAA AGGGGTTCAGGAGGTTTTGGTTCCACTGGAAAGAATTAA
- Chromosome Location
- 15
- Locus
- 15q15-q21.1
- External Identifiers
Resource Link UniProtKB ID P33316 UniProtKB Entry Name DUT_HUMAN GenBank Protein ID 2443580 GenBank Gene ID AF018432 GenAtlas ID DUT HGNC ID HGNC:3078 - General References
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