Isocitrate dehydrogenase [NADP]
Details
- Name
- Isocitrate dehydrogenase [NADP]
- Synonyms
- 1.1.1.42
- citC
- IDH
- IDP
- NADP(+)-specific ICDH
- Oxalosuccinate decarboxylase
- Gene Name
- icd
- Organism
- Bacillus subtilis (strain 168)
- Amino acid sequence
>lcl|BSEQ0011078|Isocitrate dehydrogenase [NADP] MAQGEKITVSNGVLNVPNNPIIPFIEGDGTGPDIWNAASKVLEAAVEKAYKGEKKITWKE VYAGEKAYNKTGEWLPAETLDVIREYFIAIKGPLTTPVGGGIRSLNVALRQELDLFVCLR PVRYFTGVPSPVKRPEDTDMVIFRENTEDIYAGIEYAKGSEEVQKLISFLQNELNVNKIR FPETSGIGIKPVSEEGTSRLVRAAIDYAIEHGRKSVTLVHKGNIMKFTEGAFKNWGYELA EKEYGDKVFTWAQYDRIAEEQGKDAANKAQSEAEAAGKIIIKDSIADIFLQQILTRPNEF DVVATMNLNGDYISDALAAQVGGIGIAPGANINYETGHAIFEATHGTAPKYAGLDKVNPS SVILSGVLLLEHLGWNEAADLVIKSMEKTIASKVVTYDFARLMDGATEVKCSEFGEELIK NMD
- Number of residues
- 423
- Molecular Weight
- 46417.39
- Theoretical pI
- 4.74
- GO Classification
- Functionsisocitrate dehydrogenase (NADP+) activity / magnesium ion binding / NAD bindingProcessesglyoxylate cycle / tricarboxylic acid cycle
- General Function
- Nad binding
- Specific Function
- Not Available
- Pfam Domain Function
- Iso_dh (PF00180)
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0011079|Isocitrate dehydrogenase [NADP] (icd) GTGGCACAAGGTGAAAAAATTACAGTCTCTAACGGAGTATTAAACGTACCAAACAACCCG ATTATCCCATTTATCGAAGGAGACGGAACCGGTCCTGATATTTGGAACGCGGCTTCGAAG GTTTTGGAAGCAGCAGTAGAAAAAGCATACAAAGGCGAAAAGAAAATTACATGGAAAGAA GTTTACGCCGGAGAAAAGGCTTATAATAAAACAGGTGAGTGGCTCCCTGCTGAAACATTA GATGTGATCCGCGAATATTTCATCGCGATTAAAGGCCCGTTAACGACACCTGTCGGCGGC GGTATCCGTTCTTTGAACGTAGCGCTCAGACAAGAGCTTGACCTATTCGTCTGCTTAAGA CCTGTAAGATACTTTACTGGAGTGCCGTCACCGGTAAAACGCCCTGAAGATACTGATATG GTCATCTTCCGTGAAAATACAGAAGATATTTACGCAGGCATCGAGTATGCAAAAGGCTCT GAAGAAGTGCAAAAGCTTATCAGCTTCCTTCAAAATGAGTTAAACGTCAATAAAATCCGT TTCCCTGAGACATCAGGTATCGGCATTAAGCCTGTTTCAGAAGAAGGAACAAGCCGCTTG GTCAGAGCTGCCATTGATTATGCGATCGAGCATGGCCGCAAATCTGTAACACTTGTTCAC AAAGGAAACATCATGAAGTTCACAGAAGGCGCCTTCAAAAACTGGGGCTATGAACTTGCT GAAAAAGAATACGGAGATAAAGTCTTCACATGGGCTCAATATGACCGCATTGCTGAAGAA CAAGGAAAAGACGCTGCCAACAAAGCGCAAAGCGAAGCGGAAGCAGCAGGAAAAATCATT ATCAAAGACAGCATTGCTGACATTTTCCTTCAGCAGATCTTAACGCGTCCAAACGAGTTT GATGTCGTTGCGACAATGAACTTGAACGGAGATTACATTTCTGATGCTCTTGCTGCGCAA GTCGGCGGAATCGGCATTGCTCCTGGAGCGAACATCAACTACGAAACAGGACATGCGATT TTCGAGGCGACGCACGGAACGGCTCCTAAATATGCAGGCCTTGATAAAGTAAACCCATCT TCAGTTATTCTTTCAGGCGTTCTGCTTCTTGAGCATTTAGGATGGAACGAAGCGGCTGAT TTGGTTATCAAATCTATGGAAAAAACAATCGCTTCTAAAGTCGTAACTTACGATTTTGCC AGATTAATGGACGGGGCGACTGAAGTGAAATGTTCAGAGTTCGGAGAAGAACTGATCAAA AACATGGACTAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P39126 UniProtKB Entry Name IDH_BACSU GenBank Protein ID 487434 GenBank Gene ID U05257 - General References
- Jin S, Sonenshein AL: Identification of two distinct Bacillus subtilis citrate synthase genes. J Bacteriol. 1994 Aug;176(15):4669-79. [Article]
- Lapidus A, Galleron N, Sorokin A, Ehrlich SD: Sequencing and functional annotation of the Bacillus subtilis genes in the 200 kb rrnB-dnaB region. Microbiology. 1997 Nov;143 ( Pt 11):3431-41. [Article]
- Kunst F, Ogasawara N, Moszer I, Albertini AM, Alloni G, Azevedo V, Bertero MG, Bessieres P, Bolotin A, Borchert S, Borriss R, Boursier L, Brans A, Braun M, Brignell SC, Bron S, Brouillet S, Bruschi CV, Caldwell B, Capuano V, Carter NM, Choi SK, Cordani JJ, Connerton IF, Cummings NJ, Daniel RA, Denziot F, Devine KM, Dusterhoft A, Ehrlich SD, Emmerson PT, Entian KD, Errington J, Fabret C, Ferrari E, Foulger D, Fritz C, Fujita M, Fujita Y, Fuma S, Galizzi A, Galleron N, Ghim SY, Glaser P, Goffeau A, Golightly EJ, Grandi G, Guiseppi G, Guy BJ, Haga K, Haiech J, Harwood CR, Henaut A, Hilbert H, Holsappel S, Hosono S, Hullo MF, Itaya M, Jones L, Joris B, Karamata D, Kasahara Y, Klaerr-Blanchard M, Klein C, Kobayashi Y, Koetter P, Koningstein G, Krogh S, Kumano M, Kurita K, Lapidus A, Lardinois S, Lauber J, Lazarevic V, Lee SM, Levine A, Liu H, Masuda S, Mauel C, Medigue C, Medina N, Mellado RP, Mizuno M, Moestl D, Nakai S, Noback M, Noone D, O'Reilly M, Ogawa K, Ogiwara A, Oudega B, Park SH, Parro V, Pohl TM, Portelle D, Porwollik S, Prescott AM, Presecan E, Pujic P, Purnelle B, Rapoport G, Rey M, Reynolds S, Rieger M, Rivolta C, Rocha E, Roche B, Rose M, Sadaie Y, Sato T, Scanlan E, Schleich S, Schroeter R, Scoffone F, Sekiguchi J, Sekowska A, Seror SJ, Serror P, Shin BS, Soldo B, Sorokin A, Tacconi E, Takagi T, Takahashi H, Takemaru K, Takeuchi M, Tamakoshi A, Tanaka T, Terpstra P, Togoni A, Tosato V, Uchiyama S, Vandebol M, Vannier F, Vassarotti A, Viari A, Wambutt R, Wedler H, Weitzenegger T, Winters P, Wipat A, Yamamoto H, Yamane K, Yasumoto K, Yata K, Yoshida K, Yoshikawa HF, Zumstein E, Yoshikawa H, Danchin A: The complete genome sequence of the gram-positive bacterium Bacillus subtilis. Nature. 1997 Nov 20;390(6657):249-56. [Article]
- Singh SK, Miller SP, Dean A, Banaszak LJ, LaPorte DC: Bacillus subtilis isocitrate dehydrogenase. A substrate analogue for Escherichia coli isocitrate dehydrogenase kinase/phosphatase. J Biol Chem. 2002 Mar 1;277(9):7567-73. Epub 2002 Jan 7. [Article]
- Singh SK, Matsuno K, LaPorte DC, Banaszak LJ: Crystal structure of Bacillus subtilis isocitrate dehydrogenase at 1.55 A. Insights into the nature of substrate specificity exhibited by Escherichia coli isocitrate dehydrogenase kinase/phosphatase. J Biol Chem. 2001 Jul 13;276(28):26154-63. Epub 2001 Apr 4. [Article]
Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB02159 (R)-Propylene glycol experimental unknown Details DB04272 Citric acid approved, nutraceutical, vet_approved yes substrateinhibitor Details DB04349 (S)-propane-1,2-diol experimental unknown Details DB04530 S,S-(2-Hydroxyethyl)Thiocysteine experimental unknown Details