Hydroxyethylthiazole kinase
Details
- Name
- Hydroxyethylthiazole kinase
- Synonyms
- 2.7.1.50
- 4-methyl-5-beta-hydroxyethylthiazole kinase
- TH kinase
- thiK
- Thz kinase
- ywbJ
- Gene Name
- thiM
- Organism
- Bacillus subtilis (strain 168)
- Amino acid sequence
>lcl|BSEQ0019197|Hydroxyethylthiazole kinase MDAQSAAKCLTAVRRHSPLVHSITNNVVTNFTANGLLALGASPVMAYAKEEVADMAKIAG ALVLNIGTLSKESVEAMIIAGKSANEHGVPVILDPVGAGATPFRTESARDIIREVRLAAI RGNAAEIAHTVGVTDWLIKGVDAGEGGGDIIRLAQQAAQKLNTVIAITGEVDVIADTSHV YTLHNGHKLLTKVTGAGCLLTSVVGAFCAVEENPLFAAIAAISSYGVAAQLAAQQTADKG PGSFQIELLNKLSTVTEQDVQEWATIERVTVS
- Number of residues
- 272
- Molecular Weight
- 28212.985
- Theoretical pI
- 5.58
- GO Classification
- FunctionsATP binding / hydroxyethylthiazole kinase activity / magnesium ion bindingProcessesthiamine biosynthetic process / thiamine diphosphate biosynthetic process
- General Function
- Magnesium ion binding
- Specific Function
- Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).
- Pfam Domain Function
- HK (PF02110)
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0019198|Hydroxyethylthiazole kinase (thiM) ATGGATGCACAATCAGCAGCAAAATGTCTTACGGCTGTCCGCCGGCATAGCCCACTGGTG CATAGCATAACCAACAATGTCGTAACGAATTTCACAGCAAACGGCCTGCTCGCGCTCGGC GCATCGCCCGTTATGGCGTACGCAAAAGAAGAGGTCGCCGATATGGCGAAAATTGCGGGT GCACTCGTTTTAAATATCGGAACACTGAGCAAGGAGTCAGTCGAAGCGATGATCATCGCG GGAAAATCAGCTAATGAACATGGCGTTCCCGTCATTCTTGATCCTGTCGGTGCCGGAGCA ACACCGTTCCGCACTGAATCGGCACGTGACATCATTCGTGAGGTGCGCCTTGCTGCAATC AGAGGAAATGCGGCGGAAATTGCCCATACCGTCGGCGTGACCGATTGGCTGATCAAAGGT GTTGATGCGGGTGAAGGTGGAGGCGACATCATCCGGCTGGCTCAGCAGGCGGCACAAAAG CTAAACACGGTCATTGCGATAACTGGTGAAGTTGATGTCATAGCCGACACGTCACATGTA TACACCCTTCATAACGGCCACAAGCTGCTGACAAAAGTGACAGGCGCCGGTTGCCTGCTG ACTTCCGTCGTCGGTGCGTTTTGCGCTGTGGAAGAAAATCCATTGTTTGCTGCTATTGCG GCCATTTCTTCGTATGGGGTCGCCGCTCAGCTTGCCGCACAGCAGACGGCTGACAAAGGC CCTGGAAGCTTTCAGATTGAATTGCTGAACAAGCTTTCAACTGTTACTGAACAAGACGTC CAAGAATGGGCGACTATAGAAAGGGTGACTGTCTCATGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P39593 UniProtKB Entry Name THIM_BACSU GenBank Gene ID X73124 - General References
- Glaser P, Kunst F, Arnaud M, Coudart MP, Gonzales W, Hullo MF, Ionescu M, Lubochinsky B, Marcelino L, Moszer I, et al.: Bacillus subtilis genome project: cloning and sequencing of the 97 kb region from 325 degrees to 333 degrees. Mol Microbiol. 1993 Oct;10(2):371-84. [Article]
- Kunst F, Ogasawara N, Moszer I, Albertini AM, Alloni G, Azevedo V, Bertero MG, Bessieres P, Bolotin A, Borchert S, Borriss R, Boursier L, Brans A, Braun M, Brignell SC, Bron S, Brouillet S, Bruschi CV, Caldwell B, Capuano V, Carter NM, Choi SK, Cordani JJ, Connerton IF, Cummings NJ, Daniel RA, Denziot F, Devine KM, Dusterhoft A, Ehrlich SD, Emmerson PT, Entian KD, Errington J, Fabret C, Ferrari E, Foulger D, Fritz C, Fujita M, Fujita Y, Fuma S, Galizzi A, Galleron N, Ghim SY, Glaser P, Goffeau A, Golightly EJ, Grandi G, Guiseppi G, Guy BJ, Haga K, Haiech J, Harwood CR, Henaut A, Hilbert H, Holsappel S, Hosono S, Hullo MF, Itaya M, Jones L, Joris B, Karamata D, Kasahara Y, Klaerr-Blanchard M, Klein C, Kobayashi Y, Koetter P, Koningstein G, Krogh S, Kumano M, Kurita K, Lapidus A, Lardinois S, Lauber J, Lazarevic V, Lee SM, Levine A, Liu H, Masuda S, Mauel C, Medigue C, Medina N, Mellado RP, Mizuno M, Moestl D, Nakai S, Noback M, Noone D, O'Reilly M, Ogawa K, Ogiwara A, Oudega B, Park SH, Parro V, Pohl TM, Portelle D, Porwollik S, Prescott AM, Presecan E, Pujic P, Purnelle B, Rapoport G, Rey M, Reynolds S, Rieger M, Rivolta C, Rocha E, Roche B, Rose M, Sadaie Y, Sato T, Scanlan E, Schleich S, Schroeter R, Scoffone F, Sekiguchi J, Sekowska A, Seror SJ, Serror P, Shin BS, Soldo B, Sorokin A, Tacconi E, Takagi T, Takahashi H, Takemaru K, Takeuchi M, Tamakoshi A, Tanaka T, Terpstra P, Togoni A, Tosato V, Uchiyama S, Vandebol M, Vannier F, Vassarotti A, Viari A, Wambutt R, Wedler H, Weitzenegger T, Winters P, Wipat A, Yamamoto H, Yamane K, Yasumoto K, Yata K, Yoshida K, Yoshikawa HF, Zumstein E, Yoshikawa H, Danchin A: The complete genome sequence of the gram-positive bacterium Bacillus subtilis. Nature. 1997 Nov 20;390(6657):249-56. [Article]
- Zhang Y, Taylor SV, Chiu HJ, Begley TP: Characterization of the Bacillus subtilis thiC operon involved in thiamine biosynthesis. J Bacteriol. 1997 May;179(9):3030-5. [Article]
- Campobasso N, Mathews II, Begley TP, Ealick SE: Crystal structure of 4-methyl-5-beta-hydroxyethylthiazole kinase from Bacillus subtilis at 1.5 A resolution. Biochemistry. 2000 Jul 11;39(27):7868-77. [Article]