Bifunctional protein PyrR
Details
- Name
- Bifunctional protein PyrR
- Synonyms
- 2.4.2.9
- UPRTase
- Gene Name
- pyrR
- Organism
- Bacillus caldolyticus
- Amino acid sequence
>lcl|BSEQ0016504|Bifunctional protein PyrR MQKAVVMDEQAIRRALTRIAHEIIERNKGIDGCVLVGIKTRGIYLARRLAERIEQIEGAS VPVGELDITLYRDDLTVKTDDHEPLVKGTNVPFPVTERNVILVDDVLFTGRTVRAAMDAV MDLGRPARIQLAVLVDRGHRELPIRADFVGKNVPTSRSELIVVELSEVDGIDQVSIHEK
- Number of residues
- 179
- Molecular Weight
- 19937.85
- Theoretical pI
- 5.71
- GO Classification
- FunctionsRNA binding / uracil phosphoribosyltransferase activityProcessesDNA-templated transcription, termination / nucleoside metabolic process / regulation of transcription, DNA-templated
- General Function
- Uracil phosphoribosyltransferase activity
- Specific Function
- Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes (Probable).Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.
- Pfam Domain Function
- Pribosyltran (PF00156)
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0003240|540 bp ATGCAAAAGGCGGTCGTGATGGACGAACAGGCGATTCGCCGCGCTTTGACGCGCATCGCC CACGAAATCATCGAACGAAACAAAGGCATTGACGGCTGCGTGCTTGTCGGAATTAAAACG CGCGGCATTTACTTGGCGCGCCGCTTGGCGGAGCGGATCGAGCAAATTGAAGGGGCGTCC GTTCCCGTCGGTGAGCTTGACATCACCTTGTACCGCGACGATTTGACCGTGAAGACGGAC GACCATGAACCGCTTGTGAAAGGAACGAATGTGCCGTTTCCGGTGACCGAGCGGAATGTC ATTTTAGTTGATGACGTGCTCTTCACCGGCCGGACGGTGCGGGCGGCGATGGATGCGGTC ATGGATTTGGGCCGCCCGGCGCGCATCCAGCTCGCCGTGCTTGTTGACCGCGGCCACAGG GAACTCCCGATCCGCGCTGATTTCGTCGGCAAAAACGTGCCGACCTCTCGTTCGGAACTG ATCGTCGTGGAGCTTTCGGAAGTGGACGGCATCGATCAAGTCTCCATTCATGAAAAATAG
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P41007 UniProtKB Entry Name PYRR_BACCL GenBank Protein ID 431230 GenBank Gene ID X76083 - General References
- Ghim SY, Neuhard J: The pyrimidine biosynthesis operon of the thermophile Bacillus caldolyticus includes genes for uracil phosphoribosyltransferase and uracil permease. J Bacteriol. 1994 Jun;176(12):3698-707. [Article]