Membrane-bound lytic murein transglycosylase B
Details
- Name
- Membrane-bound lytic murein transglycosylase B
- Synonyms
- 35 kDa soluble lytic transglycosylase
- 4.2.2.n1
- Murein hydrolase B
- Slt35
- Gene Name
- mltB
- Organism
- Escherichia coli (strain K12)
- Amino acid sequence
>lcl|BSEQ0016484|Membrane-bound lytic murein transglycosylase B MFKRRYVTLLPLFVLLAACSSKPKPTETDTTTGTPSGGFLLEPQHNVMQMGGDFANNPNA QQFIDKMVNKHGFDRQQLQEILSQAKRLDSVLRLMDNQAPTTSVKPPSGPNGAWLRYRKK FITPDNVQNGVVFWNQYEDALNRAWQVYGVPPEIIVGIIGVETRWGRVMGKTRILDALAT LSFNYPRRAEYFSGELETFLLMARDEQDDPLNLKGSFAGAMGYGQFMPSSYKQYAVDFSG DGHINLWDPVDAIGSVANYFKAHGWVKGDQVAVMANGQAPGLPNGFKTKYSISQLAAAGL TPQQPLGNHQQASLLRLDVGTGYQYWYGLPNFYTITRYNHSTHYAMAVWQLGQAVALARV Q
- Number of residues
- 361
- Molecular Weight
- 40255.55
- Theoretical pI
- 9.37
- GO Classification
- Functionscarbon-oxygen lyase activity, acting on polysaccharides / lytic transglycosylase activityProcessescell wall organization / peptidoglycan biosynthetic processComponentscell outer membrane
- General Function
- Lytic transglycosylase activity
- Specific Function
- Murein-degrading enzyme. Catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N-acetylglucosamine residues in peptidoglycan. May play a role in recycling of muropeptides during cell elongation and/or cell division.
- Pfam Domain Function
- SLT_2 (PF13406)
- Transmembrane Regions
- Not Available
- Cellular Location
- Cell outer membrane
- Gene sequence
>lcl|BSEQ0016485|Membrane-bound lytic murein transglycosylase B (mltB) ATGTTCAAGCGTCGTTATGTAACATTGCTTCCCCTTTTTGTGTTGCTTGCCGCCTGTAGC AGCAAGCCAAAACCTACTGAGACTGATACGACCACCGGAACGCCGTCTGGCGGCTTCCTG CTTGAGCCGCAGCACAATGTGATGCAGATGGGCGGCGATTTCGCTAATAACCCGAATGCC CAGCAGTTCATCGACAAAATGGTGAACAAACACGGTTTCGATCGTCAGCAGTTGCAGGAA ATTCTCTCCCAGGCGAAGCGTCTGGATTCGGTACTGCGGCTGATGGATAACCAGGCACCA ACCACATCGGTGAAACCGCCATCAGGTCCGAACGGCGCATGGCTCCGTTATCGCAAAAAA TTTATTACGCCGGACAACGTGCAGAACGGTGTGGTTTTCTGGAATCAGTATGAAGATGCG TTGAATCGCGCGTGGCAGGTGTATGGAGTACCGCCGGAAATTATCGTCGGGATTATCGGC GTTGAAACCCGCTGGGGGCGCGTGATGGGGAAAACTCGCATCCTCGATGCGCTGGCAACG CTGTCATTTAACTACCCACGCCGCGCGGAGTATTTCTCTGGCGAGCTGGAAACCTTCCTG TTGATGGCGCGCGACGAGCAGGACGATCCGCTCAATCTGAAAGGTTCCTTTGCCGGGGCG ATGGGCTACGGACAGTTTATGCCGTCGTCTTACAAACAATATGCGGTAGATTTCAGCGGC GACGGGCATATCAACCTGTGGGATCCGGTTGATGCGATCGGTAGCGTGGCGAACTATTTC AAAGCGCACGGCTGGGTGAAAGGCGATCAGGTCGCGGTAATGGCAAACGGTCAGGCTCCA GGCTTGCCAAATGGCTTCAAAACTAAGTACAGCATTTCGCAGCTTGCCGCCGCAGGTTTA ACGCCACAGCAGCCGCTGGGCAACCATCAACAAGCCAGCCTGCTGCGTCTGGATGTTGGC ACCGGCTACCAGTACTGGTACGGTCTGCCGAACTTCTACACCATCACCCGTTACAACCAC AGCACCCATTACGCAATGGCGGTCTGGCAGTTAGGACAAGCCGTGGCGCTGGCGCGAGTA CAGTAG
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P41052 UniProtKB Entry Name MLTB_ECOLI GenBank Protein ID 642538 GenBank Gene ID U18785 - General References
- Ehlert K, Holtje JV, Templin MF: Cloning and expression of a murein hydrolase lipoprotein from Escherichia coli. Mol Microbiol. 1995 May;16(4):761-8. [Article]
- Dijkstra AJ, Hermann F, Keck W: Cloning and controlled overexpression of the gene encoding the 35 kDa soluble lytic transglycosylase from Escherichia coli. FEBS Lett. 1995 Jun 12;366(2-3):115-8. [Article]
- Yamamoto Y, Aiba H, Baba T, Hayashi K, Inada T, Isono K, Itoh T, Kimura S, Kitagawa M, Makino K, Miki T, Mitsuhashi N, Mizobuchi K, Mori H, Nakade S, Nakamura Y, Nashimoto H, Oshima T, Oyama S, Saito N, Sampei G, Satoh Y, Sivasundaram S, Tagami H, Horiuchi T, et al.: Construction of a contiguous 874-kb sequence of the Escherichia coli -K12 genome corresponding to 50.0-68.8 min on the linkage map and analysis of its sequence features. DNA Res. 1997 Apr 28;4(2):91-113. [Article]
- Blattner FR, Plunkett G 3rd, Bloch CA, Perna NT, Burland V, Riley M, Collado-Vides J, Glasner JD, Rode CK, Mayhew GF, Gregor J, Davis NW, Kirkpatrick HA, Goeden MA, Rose DJ, Mau B, Shao Y: The complete genome sequence of Escherichia coli K-12. Science. 1997 Sep 5;277(5331):1453-62. [Article]
- Hayashi K, Morooka N, Yamamoto Y, Fujita K, Isono K, Choi S, Ohtsubo E, Baba T, Wanner BL, Mori H, Horiuchi T: Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Mol Syst Biol. 2006;2:2006.0007. Epub 2006 Feb 21. [Article]
- Yamada M, Saier MH Jr: Glucitol-specific enzymes of the phosphotransferase system in Escherichia coli. Nucleotide sequence of the gut operon. J Biol Chem. 1987 Apr 25;262(12):5455-63. [Article]
- Van Asselt EJ, Perrakis A, Kalk KH, Lamzin VS, Dijkstra BW: Accelerated X-ray structure elucidation of a 36 kDa muramidase/transglycosylase using wARP. Acta Crystallogr D Biol Crystallogr. 1998 Jan 1;54(Pt 1):58-73. [Article]
- van Asselt EJ, Dijkstra BW: Binding of calcium in the EF-hand of Escherichia coli lytic transglycosylase Slt35 is important for stability. FEBS Lett. 1999 Sep 24;458(3):429-35. [Article]
- van Asselt EJ, Dijkstra AJ, Kalk KH, Takacs B, Keck W, Dijkstra BW: Crystal structure of Escherichia coli lytic transglycosylase Slt35 reveals a lysozyme-like catalytic domain with an EF-hand. Structure. 1999 Oct 15;7(10):1167-80. [Article]
- van Asselt EJ, Kalk KH, Dijkstra BW: Crystallographic studies of the interactions of Escherichia coli lytic transglycosylase Slt35 with peptidoglycan. Biochemistry. 2000 Feb 29;39(8):1924-34. [Article]