3-deoxy-manno-octulosonate cytidylyltransferase
Details
- Name
- 3-deoxy-manno-octulosonate cytidylyltransferase
- Synonyms
- 2.7.7.38
- CKS
- CMP-2-keto-3-deoxyoctulosonic acid synthase
- CMP-KDO synthase
- Gene Name
- kpsU
- Organism
- Escherichia coli
- Amino acid sequence
>lcl|BSEQ0011077|3-deoxy-manno-octulosonate cytidylyltransferase MSKAVIVIPARYGSSRLPGKPLLDIVGKPMIQHVYERALQVAGVAEVWVATDDPRVEQAV QAFGGKAIMTRNDHESGTDRLVEVMHKVEADIYINLQGDEPMIRPRDVETLLQGMRDDPA LPVATLCHAISAAEAAEPSTVKVVVNTRQDALYFSRSPIPYPRNAEKARYLKHVGIYAYR RDVLQNYSQLPESMPEQAESLEQLRLMNAGINIRTFEVAATGPGVDTPACLEKVRALMAQ ELAENA
- Number of residues
- 246
- Molecular Weight
- 27158.885
- Theoretical pI
- 5.7
- GO Classification
- Functions3-deoxy-manno-octulosonate cytidylyltransferase activityProcessesCMP-keto-3-deoxy-D-manno-octulosonic acid biosynthetic process / keto-3-deoxy-D-manno-octulosonic acid biosynthetic processComponentscytoplasm
- General Function
- 3-deoxy-manno-octulosonate cytidylyltransferase activity
- Specific Function
- Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
- Pfam Domain Function
- CTP_transf_3 (PF02348)
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0003021|741 bp ATGAGCAAAGCAGTTATTGTCATTCCGGCTCGCTATGGCTCCTCGCGCCTGCCGGGTAAG CCACTGCTCGATATTGTTGGTAAACCGATGATCCAGCATGTTTACGAGCGTGCGTTACAG GTGGCGGGCGTTGCGGAAGTTTGGGTGGCAACAGACGATCCGCGTGTTGAACAGGCCGTA CAGGCGTTTGGCGGGAAAGCCATCATGACGCGCAACGATCATGAATCCGGCACCGATCGG CTGGTCGAGGTGATGCATAAAGTCGAGGCAGATATCTACATTAACCTGCAGGGCGACGAA CCAATGATTCGCCCGCGGGATGTAGAAACGCTGCTACAAGGAATGCGTGACGATCCCGCG TTGCCGGTGGCAACGCTATGCCACGCGATTTCTGCCGCAGAAGCGGCTGAGCCAAGCACG GTAAAAGTGGTTGTGAATACCCGCCAGGATGCGCTTTATTTCAGCCGCTCACCGATTCCG TATCCGCGTAATGCTGAAAAAGCGCGCTACCTGAAACACGTCGGTATTTACGCTTATCGT CGCGATGTGCTGCAAAACTACAGCCAGTTACCGGAGTCCATGCCGGAGCAGGCGGAATCA CTGGAGCAGCTAAGGTTGATGAACGCGGGGATCAACATCCGCACATTTGAGGTTGCCGCA ACCGGTCCGGGCGTCGACACCCCAGCATGCCTGGAAAAAGTGCGCGCCCTGATGGCACAG GAACTGGCTGAAAACGCATGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P42216 UniProtKB Entry Name KPSU5_ECOLX GenBank Protein ID 397407 GenBank Gene ID X74567 - General References
- Pazzani C, Rosenow C, Boulnois GJ, Bronner D, Jann K, Roberts IS: Molecular analysis of region 1 of the Escherichia coli K5 antigen gene cluster: a region encoding proteins involved in cell surface expression of capsular polysaccharide. J Bacteriol. 1993 Sep;175(18):5978-83. [Article]
- Rosenow C, Roberts IS, Jann K: Isolation from recombinant Escherichia coli and characterization of CMP-Kdo synthetase, involved in the expression of the capsular K5 polysaccharide (K-CKS). FEMS Microbiol Lett. 1995 Jan 15;125(2-3):159-64. [Article]
- Jelakovic S, Jann K, Schulz GE: The three-dimensional structure of capsule-specific CMP: 2-keto-3-deoxy-manno-octonic acid synthetase from Escherichia coli. FEBS Lett. 1996 Aug 5;391(1-2):157-61. [Article]
Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB03721 N-acetyl-alpha-neuraminic acid experimental unknown Details DB02431 Cytidine-5'-Triphosphate experimental unknown Details DB03403 Cytidine-5'-Monophosphate experimental unknown Details DB04482 Cmp-2-Keto-3-Deoxy-Octulosonic Acid experimental unknown Details DB04555 Cytidine-5'-Diphosphate experimental unknown Details