Biphenyl-2,3-diol 1,2-dioxygenase
Details
- Name
- Biphenyl-2,3-diol 1,2-dioxygenase
- Synonyms
- 1.13.11.39
- 2,3-dihydroxybiphenyl dioxygenase
- 23OHBP oxygenase
- DHBD
- Gene Name
- bphC
- Organism
- Burkholderia xenovorans (strain LB400)
- Amino acid sequence
>lcl|BSEQ0010914|Biphenyl-2,3-diol 1,2-dioxygenase MSIRSLGYMGFAVSDVAAWRSFLTQKLGLMEAGTTDNGDLFRIDSRAWRIAVQQGEVDDL AFAGYEVADAAGLAQMADKLKQAGIAVTTGDASLARRRGVTGLITFADPFGLPLEIYYGA SEVFEKPFLPGAAVSGFLTGEQGLGHFVRCVPDSDKALAFYTDVLGFQLSDVIDMKMGPD VTVPAYFLHCNERHHTLAIAAFPLPKRIHHFMLEVASLDDVGFAFDRVDADGLITSTLGR HTNDHMVSFYASTPSGVEVEYGWSARTVDRSWVVVRHDSPSMWGHKSVRDKAAARNKA
- Number of residues
- 298
- Molecular Weight
- 32470.515
- Theoretical pI
- 5.99
- GO Classification
- Functionsbiphenyl-2,3-diol 1,2-dioxygenase activity / ferrous iron bindingProcessesaromatic compound catabolic process / xenobiotic catabolic process
- General Function
- Ferrous iron binding
- Specific Function
- Shows a preference for catechols with groups immediately adjacent to the hydroxyl substituents.
- Pfam Domain Function
- Glyoxalase (PF00903)
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0010915|Biphenyl-2,3-diol 1,2-dioxygenase (bphC) ATGAGCATCAGAAGTTTGGGATACATGGGGTTTGCGGTCAGCGACGTAGCTGCTTGGCGT TCGTTTCTGACGCAGAAACTGGGCTTGATGGAAGCGGGCACGACCGACAACGGCGACCTG TTCCGCATCGATTCGAGAGCCTGGCGGATCGCCGTTCAGCAGGGCGAGGTTGACGATCTG GCCTTTGCCGGCTACGAGGTGGCCGATGCGGCAGGGCTGGCGCAGATGGCTGACAAGCTC AAACAGGCCGGTATCGCAGTCACCACCGGCGATGCCTCATTGGCCAGGCGCCGCGGGGTG ACCGGATTGATCACCTTTGCCGACCCGTTTGGCCTGCCGTTGGAAATTTACTATGGCGCC AGCGAGGTGTTCGAAAAACCGTTCCTGCCTGGTGCGGCCGTGTCGGGTTTCCTGACCGGC GAGCAAGGGCTGGGGCATTTCGTGCGCTGCGTTCCGGATTCGGACAAGGCGCTGGCGTTT TATACCGACGTGCTCGGCTTCCAGTTGTCTGACGTCATCGACATGAAAATGGGGCCGGAC GTGACGGTTCCTGCGTACTTCCTGCACTGCAACGAACGCCACCACACCCTGGCAATTGCG GCATTCCCGCTGCCAAAACGCATTCATCACTTCATGCTCGAAGTCGCCTCGCTCGATGAC GTCGGCTTTGCATTTGATCGGGTTGACGCGGACGGCTTGATCACCTCCACGCTGGGGCGC CACACCAATGACCACATGGTGTCGTTCTATGCCTCGACCCCGTCCGGAGTAGAGGTCGAG TATGGCTGGAGTGCCCGTACCGTTGACCGCTCCTGGGTTGTGGTGAGGCACGACAGTCCG AGCATGTGGGGCCACAAGTCTGTGCGCGACAAAGCAGCTGCGCGCAACAAAGCATGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P47228 UniProtKB Entry Name BPHC_BURXL GenBank Protein ID 397884 GenBank Gene ID X66122 - General References
- Hofer B, Eltis LD, Dowling DN, Timmis KN: Genetic analysis of a Pseudomonas locus encoding a pathway for biphenyl/polychlorinated biphenyl degradation. Gene. 1993 Aug 16;130(1):47-55. [Article]
- Chain PS, Denef VJ, Konstantinidis KT, Vergez LM, Agullo L, Reyes VL, Hauser L, Cordova M, Gomez L, Gonzalez M, Land M, Lao V, Larimer F, LiPuma JJ, Mahenthiralingam E, Malfatti SA, Marx CJ, Parnell JJ, Ramette A, Richardson P, Seeger M, Smith D, Spilker T, Sul WJ, Tsoi TV, Ulrich LE, Zhulin IB, Tiedje JM: Burkholderia xenovorans LB400 harbors a multi-replicon, 9.73-Mbp genome shaped for versatility. Proc Natl Acad Sci U S A. 2006 Oct 17;103(42):15280-7. Epub 2006 Oct 9. [Article]
- Eltis LD, Hofmann B, Hecht HJ, Lunsdorf H, Timmis KN: Purification and crystallization of 2,3-dihydroxybiphenyl 1,2-dioxygenase. J Biol Chem. 1993 Feb 5;268(4):2727-32. [Article]
- Han S, Eltis LD, Timmis KN, Muchmore SW, Bolin JT: Crystal structure of the biphenyl-cleaving extradiol dioxygenase from a PCB-degrading pseudomonad. Science. 1995 Nov 10;270(5238):976-80. [Article]
- Vaillancourt FH, Han S, Fortin PD, Bolin JT, Eltis LD: Molecular basis for the stabilization and inhibition of 2, 3-dihydroxybiphenyl 1,2-dioxygenase by t-butanol. J Biol Chem. 1998 Dec 25;273(52):34887-95. [Article]
Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB01925 2'-Chloro-Biphenyl-2,3-Diol experimental unknown Details DB02232 1,2-Dihydroxybenzene experimental unknown Details DB02923 Biphenyl-2,3-Diol experimental unknown Details DB03259 2',6'-Dichloro-Biphenyl-2,6-Diol experimental unknown Details DB03454 3-methyl-benzene-1,2-diol experimental unknown Details DB03900 tert-butanol experimental unknown Details