Galectin-7
Details
- Name
- Galectin-7
- Synonyms
- Gal-7
- HKL-14
- p53-induced gene 1 protein
- PI7
- PIG1
- Gene Name
- LGALS7
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0010705|Galectin-7 MSNVPHKSSLPEGIRPGTVLRIRGLVPPNASRFHVNLLCGEEQGSDAALHFNPRLDTSEV VFNSKEQGSWGREERGPGVPFQRGQPFEVLIIASDDGFKAVVGDAQYHHFRHRLPLARVR LVEVGGDVQLDSVRIF
- Number of residues
- 136
- Molecular Weight
- 15074.965
- Theoretical pI
- 7.79
- GO Classification
- Functionscarbohydrate bindingProcessesapoptotic process / heterophilic cell-cell adhesion via plasma membrane cell adhesion moleculesComponentscytoplasm / extracellular exosome / extracellular space / nucleus
- General Function
- Carbohydrate binding
- Specific Function
- Could be involved in cell-cell and/or cell-matrix interactions necessary for normal growth control. Pro-apoptotic protein that functions intracellularly upstream of JNK activation and cytochrome c release.
- Pfam Domain Function
- Gal-bind_lectin (PF00337)
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0010706|Galectin-7 (LGALS7) ATGTCCAACGTCCCCCACAAGTCCTCACTGCCCGAGGGCATCCGCCCTGGCACGGTGCTG AGAATTCGCGGCTTGGTTCCTCCCAATGCCAGCAGGTTCCATGTAAACCTGCTGTGCGGG GAGGAGCAGGGCTCCGATGCCGCGCTGCATTTCAACCCCCGGCTGGACACGTCGGAGGTG GTCTTCAACAGCAAGGAGCAAGGCTCCTGGGGCCGCGAGGAGCGCGGGCCGGGCGTTCCT TTCCAGCGCGGGCAGCCCTTCGAGGTGCTCATCATCGCGTCAGACGACGGCTTCAAGGCC GTGGTTGGGGACGCCCAGTACCACCACTTCCGCCACCGCCTGCCGCTGGCGCGCGTGCGC CTGGTGGAGGTGGGCGGGGACGTGCAGCTGGACTCCGTGAGGATCTTCTGA
- Chromosome Location
- 19
- Locus
- 19q13.2
- External Identifiers
Resource Link UniProtKB ID P47929 UniProtKB Entry Name LEG7_HUMAN GenBank Protein ID 182132 GenBank Gene ID L07769 GenAtlas ID LGALS7 HGNC ID HGNC:6568 - General References
- Madsen P, Rasmussen HH, Flint T, Gromov P, Kruse TA, Honore B, Vorum H, Celis JE: Cloning, expression, and chromosome mapping of human galectin-7. J Biol Chem. 1995 Mar 17;270(11):5823-9. [Article]
- Magnaldo T, Bernerd F, Darmon M: Galectin-7, a human 14-kDa S-lectin, specifically expressed in keratinocytes and sensitive to retinoic acid. Dev Biol. 1995 Apr;168(2):259-71. [Article]
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- Kuwabara I, Kuwabara Y, Yang RY, Schuler M, Green DR, Zuraw BL, Hsu DK, Liu FT: Galectin-7 (PIG1) exhibits pro-apoptotic function through JNK activation and mitochondrial cytochrome c release. J Biol Chem. 2002 Feb 1;277(5):3487-97. Epub 2001 Nov 8. [Article]
- Leonidas DD, Vatzaki EH, Vorum H, Celis JE, Madsen P, Acharya KR: Structural basis for the recognition of carbohydrates by human galectin-7. Biochemistry. 1998 Oct 6;37(40):13930-40. [Article]