4-trimethylaminobutyraldehyde dehydrogenase
Details
- Name
- 4-trimethylaminobutyraldehyde dehydrogenase
- Synonyms
- 1.2.1.47
- Aldehyde dehydrogenase E3 isozyme
- Aldehyde dehydrogenase family 9 member A1
- ALDH4
- ALDH7
- ALDH9
- Gamma-aminobutyraldehyde dehydrogenase
- R-aminobutyraldehyde dehydrogenase
- TMABADH
- Gene Name
- ALDH9A1
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0000571|4-trimethylaminobutyraldehyde dehydrogenase MSTGTFVVSQPLNYRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKA AFKIWSQKSGMERCRILLEAARIIREREDEIATMECINNGKSIFEARLDIDISWQCLEYY AGLAASMAGEHIQLPGGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFK PSPFTPVSALLLAEIYSEAGVPPGLFNVVQGGAATGQFLCQHPDVAKVSFTGSVPTGMKI MEMSAKGIKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEI LDKFTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIY VPEDPKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLA AGVFTRDIQRAHRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQL KTVCVEMGDVESAF
- Number of residues
- 494
- Molecular Weight
- 53801.495
- Theoretical pI
- 5.61
- GO Classification
- Functions1-pyrroline dehydrogenase activity / 3-chloroallyl aldehyde dehydrogenase activity / 4-trimethylammoniobutyraldehyde dehydrogenase activity / aldehyde dehydrogenase (NAD) activity / aminobutyraldehyde dehydrogenase activityProcessesbranched-chain amino acid catabolic process / carnitine biosynthetic process / cellular aldehyde metabolic process / cellular nitrogen compound metabolic process / hormone metabolic process / neurotransmitter biosynthetic process / oxidation-reduction process / small molecule metabolic processComponentscytoplasm / cytosol / extracellular exosome / mitochondrion
- General Function
- Aminobutyraldehyde dehydrogenase activity
- Specific Function
- Converts gamma-trimethylaminobutyraldehyde into gamma-butyrobetaine. Catalyzes the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction.
- Pfam Domain Function
- Aldedh (PF00171)
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0010063|4-trimethylaminobutyraldehyde dehydrogenase (ALDH9A1) ATGTTTCTCCGAGCAGGCCTGGCCGCGCTCTCCCCGCTTCTTCGCAGTCTTCGGCCCTCT CCTGTCGCCGCCATGAGCACTGGCACCTTCGTCGTGTCGCAGCCGCTCAATTACCGCGGC GGGGCCCGCGTGGAGCCGGCGGACGCCTCCGGTACCGAGAAAGCTTTCGAGCCAGCAACC GGCCGAGTGATAGCTACTTTCACATGTTCAGGAGAAAAGGAAGTAAATTTGGCTGTTCAA AATGCAAAGGCTGCTTTTAAAATATGGAGTCAAAAATCTGGCATGGAGCGTTGCCGAATC CTTTTGGAGGCTGCCAGGATAATAAGGGAACGGGAGGATGAAATTGCTACTATGGAGTGC ATCAACAATGGCAAGTCCATCTTTGAGGCCCGCTTGGACATTGACATTTCCTGGCAGTGC CTGGAGTATTATGCGGGCTTGGCTGCATCCATGGCTGGTGAACACATCCAGCTCCCAGGT GGATCGTTTGGTTATACCAGAAGAGAACCACTTGGGGTATGTGTGGGAATAGGAGCATGG AACTACCCCTTTCAGATTGCCTCTTGGAAGTCGGCTCCAGCATTAGCCTGTGGTAATGCC ATGGTCTTTAAACCTTCTCCCTTTACACCTGTTTCTGCATTGCTACTGGCTGAAATCTAC AGTGAGGCTGGTGTACCTCCTGGGCTCTTCAATGTGGTGCAGGGAGGGGCTGCCACAGGC CAGTTTCTGTGTCAGCATCCCGATGTGGCCAAAGTCTCCTTCACTGGAAGTGTGCCCACT GGCATGAAGATCATGGAGATGTCAGCTAAAGGAATCAAACCTGTTACCTTGGAACTTGGA GGCAAATCTCCACTCATCATCTTCTCAGACTGTGATATGAACAATGCTGTAAAGGGGGCG CTGATGGCCAACTTCCTCACACAAGGCCAGGTTTGCTGTAATGGCACAAGAGTATTTGTG CAGAAAGAAATTCTTGATAAATTTACAGAGGAAGTGGTGAAACAGACCCAAAGGATTAAA ATTGGAGATCCCCTTCTGGAAGATACAAGGATGGGTCCACTCATCAACCGACCACACCTG GAGCGAGTCCTTGGGTTTGTCAAAGTGGCAAAGGAGCAGGGTGCTAAAGTGTTATGTGGT GGAGATATATATGTACCTGAAGATCCCAAATTAAAGGATGGATATTACATGAGACCTTGT GTATTAACTAATTGCAGAGACGACATGACCTGTGTGAAGGAAGAGATCTTTGGGCCTGTT ATGTCCATTTTATCATTTGACACTGAAGCTGAGGTTCTAGAAAGAGCCAATGATACCACT TTTGGACTAGCAGCTGGCGTCTTTACCAGGGACATCCAACGGGCTCATAGAGTGGTAGCT GAGCTTCAGGCTGGGACGTGCTTCATTAACAACTATAACGTCAGCCCAGTGGAGTTGCCC TTTGGTGGATATAAGAAGTCAGGATTTGGCAGAGAGAACGGCCGTGTGACAATCGAATAT TATTCACAGCTGAAGACTGTGTGTGTGGAGATGGGTGATGTGGAATCTGCTTTTTGA
- Chromosome Location
- 1
- Locus
- 1q23.1
- External Identifiers
Resource Link UniProtKB ID P49189 UniProtKB Entry Name AL9A1_HUMAN GenBank Protein ID 1049219 GenBank Gene ID U34252 GenAtlas ID ALDH9A1 HGNC ID HGNC:412 - General References
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