Dual specificity protein kinase CLK1
Details
- Name
- Dual specificity protein kinase CLK1
- Synonyms
- 2.7.12.1
- CDC-like kinase 1
- CLK
- Gene Name
- CLK1
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0037148|Dual specificity protein kinase CLK1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESR SINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIH HSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECID HKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIV FELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSD YTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPC DVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWD EHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLL KKSI
- Number of residues
- 484
- Molecular Weight
- 57290.145
- Theoretical pI
- 9.02
- GO Classification
- FunctionsATP binding / non-membrane spanning protein tyrosine kinase activity / protein serine/threonine kinase activity / protein serine/threonine/tyrosine kinase activityProcessescell proliferation / peptidyl-serine phosphorylation / peptidyl-threonine phosphorylation / protein autophosphorylation / regulation of RNA splicingComponentscytoplasm / nucleus
- General Function
- Protein serine/threonine/tyrosine kinase activity
- Specific Function
- Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates: SRSF1, SRSF3 and PTPN1. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells and adenovirus E1A pre-mRNA.
- Pfam Domain Function
- Pkinase (PF00069)
- Transmembrane Regions
- Not Available
- Cellular Location
- Nucleus
- Gene sequence
>lcl|BSEQ0011307|Dual specificity protein kinase CLK1 (CLK1) ATGGCGGCTGGGCGGAGGCCGGCTTCGGCCCTGTGGCCGGAAAGGCGAGGCTCCCCGTTG AGGGGGGATTTGCTGGGGTTCCAGAATGTGCGTGAGCCAAGCAGCTGTGGGGAAACGTTG TCTGGAATGAGACACTCAAAGAGAACTTACTGTCCTGATTGGGATGACAAGGATTGGGAT TATGGAAAATGGAGGAGCAGCAGCAGTCATAAAAGAAGGAAGAGATCACATAGCAGTGCC CAGGAGAACAAGCGCTGCAAATACAATCACTCTAAAATGTGTGATAGCCATTATTTGGAA AGCAGGTCTATAAATGAGAAAGATTATCATAGTCGACGCTACATTGATGAGTACAGAAAT GACTACACTCAAGGATGTGAACCTGGACATCGCCAAAGAGACCATGAAAGCCGGTATCAG AACCATAGTAGCAAGTCTTCTGGTAGAAGTGGAAGAAGTAGTTATAAAAGCAAACACAGG ATTCACCACAGTACTTCACATCGTCGTTCACATGGGAAGAGTCACCGAAGGAAAAGAACC AGGAGTGTAGAGGATGATGAGGAGGGTCACCTGATCTGTCAGAGTGGAGACGTACTAAGT GCAAGATATGAAATTGTTGATACTTTAGGTGAAGGAGCTTTTGGAAAAGTTGTGGAGTGC ATCGATCATAAAGCGGGAGGTAGACATGTAGCAGTAAAAATAGTTAAAAATGTGGATAGA TACTGTGAAGCTGCTCGCTCAGAAATACAAGTTCTGGAACATCTGAATACAACAGACCCC AACAGTACTTTCCGCTGTGTCCAGATGTTGGAATGGTTTGAGCATCATGGTCACATTTGC ATTGTTTTTGAACTATTGGGACTTAGTACTTACGACTTCATTAAAGAAAATGGTTTTCTA CCATTTCGACTGGATCATATCAGAAAGATGGCATATCAGATATGCAAGTCTGTGAATTTT TTGCACAGTAATAAGTTGACTCACACAGACTTAAAGCCTGAAAACATCTTATTTGTGCAG TCTGACTACACAGAGGCGTATAATCCCAAAATAAAACGTGATGAACGCACCTTAATAAAT CCAGATATTAAAGTTGTAGACTTTGGTAGTGCAACATATGATGACGAACATCACAGTACA TTGGTATCTACAAGACATTATAGAGCACCTGAAGTTATTTTAGCCCTAGGGTGGTCCCAA CCATGTGATGTCTGGAGCATAGGATGCATTCTTATTGAATACTATCTTGGGTTTACCGTA TTTCCAACACACGATAGTAAGGAGCATTTAGCAATGATGGAAAGGATTCTTGGACCTCTA CCAAAACATATGATACAGAAAACCAGGAAACGTAAATATTTTCACCACGATCGATTAGAC TGGGATGAACACAGTTCTGCCGGCAGATATGTTTCAAGACGCTGTAAACCTCTGAAGGAA TTTATGCTTTCTCAAGATGTTGAACATGAGCGTCTCTTTGACCTCATTCAGAAAATGTTG GAGTATGATCCAGCCAAAAGAATTACTCTCAGAGAAGCCTTAAAGCATCCTTTCTTTGAC CTTCTGAAGAAAAGTATATAG
- Chromosome Location
- 2
- Locus
- 2q33
- External Identifiers
Resource Link UniProtKB ID P49759 UniProtKB Entry Name CLK1_HUMAN GenBank Protein ID 632964 GenBank Gene ID L29219 GenAtlas ID CLK1 HGNC ID HGNC:2068 - General References
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Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB04367 Debromohymenialdisine experimental unknown Details DB06376 CHGN111 investigational unknown Details DB08691 ethyl 3-[(E)-2-amino-1-cyanoethenyl]-6,7-dichloro-1-methyl-1H-indole-2-carboxylate experimental unknown Details DB12010 Fostamatinib approved, investigational unknown inhibitor Details