Streptogramin A acetyltransferase
Details
- Name
- Streptogramin A acetyltransferase
- Synonyms
- 2.3.1.-
- satA
- Vat(D)
- Virginiamycin acetyltransferase D
- Gene Name
- vatD
- Organism
- Enterococcus faecium
- Amino acid sequence
>lcl|BSEQ0021973|Streptogramin A acetyltransferase MGPNPMKMYPIEGNKSVQFIKPILEKLENVEVGEYSYYDSKNGETFDKQILYHYPILNDK LKIGKFCSIGPGVTIIMNGANHRMDGSTYPFNLFGNGWEKHMPKLDQLPIKGDTIIGNDV WIGKDVVIMPGVKIGDGAIVAANSVVVKDIAPYMLAGGNPANEIKQRFDQDTINQLLDIK WWNWPIDIINENIDKILDNSIIREVIWKK
- Number of residues
- 209
- Molecular Weight
- 23649.22
- Theoretical pI
- 5.75
- GO Classification
- Functionstransferase activity, transferring acyl groupsProcessesresponse to antibiotic
- General Function
- Transferase activity, transferring acyl groups
- Specific Function
- Inactivates the A compounds of streptogramin antibiotics by acetylation, thus providing resistance to these antibiotics.
- Pfam Domain Function
- Hexapep (PF00132)
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0002464|630 bp ATGGGTCCGAATCCTATGAAAATGTATCCTATAGAAGGAAACAAATCAGTACAATTTATC AAACCTATTTTAGAAAAATTAGAAAATGTTGAGGTTGGAGAATACTCATATTATGATTCT AAGAATGGAGAAACTTTTGATAAGCAAATTTTATATCATTATCCAATCTTAAACGATAAG TTAAAAATAGGTAAATTTTGCTCAATAGGACCAGGTGTAACTATTATTATGAATGGAGCA AATCATAGAATGGATGGCTCAACATATCCATTTAATTTATTTGGTAATGGATGGGAGAAA CATATGCCAAAATTAGATCAACTACCTATTAAGGGGGATACAATAATAGGTAATGATGTA TGGATAGGAAAAGATGTTGTAATTATGCCAGGAGTAAAAATCGGGGATGGTGCAATAGTA GCTGCTAATTCTGTTGTTGTAAAAGATATAGCGCCATACATGTTAGCTGGAGGAAATCCT GCTAACGAAATAAAACAAAGATTTGATCAAGATACAATAAATCAGCTGCTTGATATAAAA TGGTGGAATTGGCCAATAGACATTATTAATGAGAATATAGATAAAATTCTTGATAATAGC ATCATTAGAGAAGTCATATGGAAAAAATGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P50870 UniProtKB Entry Name VATD_ENTFC GenBank Protein ID 433715 GenBank Gene ID L12033 - General References
- Rende-Fournier R, Leclercq R, Galimand M, Duval J, Courvalin P: Identification of the satA gene encoding a streptogramin A acetyltransferase in Enterococcus faecium BM4145. Antimicrob Agents Chemother. 1993 Oct;37(10):2119-25. [Article]
- Sugantino M, Roderick SL: Crystal structure of Vat(D): an acetyltransferase that inactivates streptogramin group A antibiotics. Biochemistry. 2002 Feb 19;41(7):2209-16. [Article]
- Kehoe LE, Snidwongse J, Courvalin P, Rafferty JB, Murray IA: Structural basis of Synercid (quinupristin-dalfopristin) resistance in Gram-positive bacterial pathogens. J Biol Chem. 2003 Aug 8;278(32):29963-70. Epub 2003 May 27. [Article]