Peroxisomal multifunctional enzyme type 2
Details
- Name
- Peroxisomal multifunctional enzyme type 2
- Synonyms
- 17-beta-HSD 4
- 17-beta-hydroxysteroid dehydrogenase 4
- D-bifunctional protein
- DBP
- EDH17B4
- MFE-2
- MPF-2
- Multifunctional protein 2
- SDR8C1
- Short chain dehydrogenase/reductase family 8C member 1
- Gene Name
- HSD17B4
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0037011|Peroxisomal multifunctional enzyme type 2 MGSPLRFDGRVVLVTGAGAGLGRAYALAFAERGALVVVNDLGGDFKGVGKGSLAADKVVE EIRRRGGKAVANYDSVEEGEKVVKTALDAFGRIDVVVNNAGILRDRSFARISDEDWDIIH RVHLRGSFQVTRAAWEHMKKQKYGRIIMTSSASGIYGNFGQANYSAAKLGLLGLANSLAI EGRKSNIHCNTIAPNAGSRMTQTVMPEDLVEALKPEYVAPLVLWLCHESCEENGGLFEVG AGWIGKLRWERTLGAIVRQKNHPMTPEAVKANWKKICDFENASKPQSIQESTGSIIEVLS KIDSEGGVSANHTSRATSTATSGFAGAIGQKLPPFSYAYTELEAIMYALGVGASIKDPKD LKFIYEGSSDFSCLPTFGVIIGQKSMMGGGLAEIPGLSINFAKVLHGEQYLELYKPLPRA GKLKCEAVVADVLDKGSGVVIIMDVYSYSEKELICHNQFSLFLVGSGGFGGKRTSDKVKV AVAIPNRPPDAVLTDTTSLNQAALYRLSGDWNPLHIDPNFASLAGFDKPILHGLCTFGFS ARRVLQQFADNDVSRFKAIKARFAKPVYPGQTLQTEMWKEGNRIHFQTKVQETGDIVISN AYVDLAPTSGTSAKTPSEGGKLQSTFVFEEIGRRLKDIGPEVVKKVNAVFEWHITKGGNI GAKWTIDLKSGSGKVYQGPAKGAADTTIILSDEDFMEVVLGKLDPQKAFFSGRLKARGNI MLSQKLQMILKDYAKL
- Number of residues
- 736
- Molecular Weight
- 79685.715
- Theoretical pI
- 9.21
- GO Classification
- Functions17-beta-hydroxysteroid dehydrogenase (NAD+) activity / 3-hydroxyacyl-CoA dehydrogenase activity / 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity / isomerase activity / long-chain-enoyl-CoA hydratase activity / protein homodimerization activity / receptor bindingProcessesalpha-linolenic acid metabolic process / androgen metabolic process / bile acid biosynthetic process / bile acid metabolic process / cellular lipid metabolic process / estrogen metabolic process / fatty acid beta-oxidation / fatty acid beta-oxidation using acyl-CoA oxidase / medium-chain fatty-acyl-CoA metabolic process / osteoblast differentiation / oxidation-reduction process / Sertoli cell development / small molecule metabolic process / unsaturated fatty acid metabolic process / very long-chain fatty acid metabolic process / very long-chain fatty-acyl-CoA metabolic processComponentsintracellular membrane-bounded organelle / membrane / mitochondrion / peroxisomal matrix / peroxisomal membrane / peroxisome
- General Function
- Receptor binding
- Specific Function
- Bifunctional enzyme acting on the peroxisomal beta-oxidation pathway for fatty acids. Catalyzes the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids.
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Peroxisome
- Gene sequence
>lcl|BSEQ0010284|Peroxisomal multifunctional enzyme type 2 (HSD17B4) ATGGTTATTCTTGAGGCACCGCATCTCTTGAGGAGGAAAGAGCCGGAAACACCTGGTCTC TCAAGCAGGATTGGGCCGAGCCTATGCCCTGGCTTTTGCAGAAAGAGGAGCGTTAGTTGT TGCTTTCAAAATCTATGCAATAACCCTATGGAGAAGATCATTTCACAATGCAGATTCTTT GTTTCAATGAATGATTTGGGAGGGGACTTCAAAGGAGTTGGTAAAGGCTCCTTAGCTGCT GATAAGGTTGTTGAAGAAATAAGAAGGAGAGGTGGAAAAGCAGTGGCCAACTATGATTCA GTGGAAGAAGGAGAGAAGGTTGTGAAGACAGCCCTGGATGCTTTTGGAAGAATAGATGTT GTGGTCAACAATGCTGGAATTCTGAGGGATCGTTCCTTTGCTAGGATAAGTGATGAAGAC TGGGATATAATCCACAGAGTTCATTTGCGGGGTTCATTCCAAGTGACACGGGCAGCATGG GAACACATGAAGAAACAGAAGTATGGAAGGATTATTATGACTTCATCAGCTTCAGGAATA TATGGCAACTTTGGCCAGGCCAATTATAGTGCTGCAAAGTTGGGTCTTCTGGGCCTTGCA AATTCTCTTGCAATTGAAGGCAGGAAAAGCAACATTCATTGTAACACCATTGCTCCTAAT GCGGGATCACGGATGACTCAGACAGTTATGCCTGAAGATCTTGTGGAAGCCCTGAAGCCA GAGTATGTGGCACCTCTTGTCCTTTGGCTTTGTCACGAGAGTTGTGAGGAGAATGGTGGC TTGTTTGAGGTTGGAGCAGGATGGATTGGAAAATTACGCTGGGAGCGGACTCTTGGAGCT ATTGTAAGACAAAAGAATCACCCAATGACTCCTGAGGCAGTCAAGGCTAACTGGAAGAAG ATCTGTGACTTTGAGAATGCCAGCAAGCCTCAGAGTATCCAAGAATCAACTGGCAGTATA ATTGAAGTTCTGAGTAAAATAGATTCAGAAGGAGGAGTTTCAGCAAATCATACTAGTCGT GCAACGTCTACAGCAACATCAGGATTTGCTGGAGCTATTGGCCAGAAACTCCCTCCATTT TCTTATGCTTATACGGAACTGGAAGCTATTATGTATGCCCTTGGAGTGGGAGCGTCAATC AAGGATCCAAAAGATTTGAAATTTATTTATGAAGGAAGTTCTGATTTCTCCTGTTTGCCC ACCTTCGGAGTTATCATAGGTCAGAAATCTATGATGGGTGGAGGATTAGCAGAAATTCCT GGACTTTCAATCAACTTTGCAAAGGTTCTTCATGGAGAGCAGTACTTAGAGTTATATAAA CCACTTCCCAGAGCAGGAAAATTAAAATGTGAAGCAGTTGTTGCTGATGTCCTAGATAAA GGATCCGGTGTAGTGATTATTATGGATGTCTATTCTTATTCTGAGAAGGAACTTATATGC CACAATCAGTTCTCTCTCTTTCTTGTTGGCTCTGGAGGCTTTGGTGGAAAACGGACATCA GACAAAGTCAAGGTAGCTGTAGCCATACCTAATAGACCTCCTGATGCTGTACTTACAGAT ACCACCTCTCTTAATCAGGCTGCTTTGTACCGCCTCAGTGGAGACTGGAATCCCTTACAC ATTGATCCTAACTTTGCTAGTCTAGCAGGTTTTGACAAGCCCATATTACATGGATTATGT ACATTTGGATTTTCTGCCAGGCGTGTGTTACAGCAGTTTGCAGATAATGATGTGTCAAGA TTCAAGGCAATTAAGGCTCGTTTTGCAAAACCAGTATATCCAGGACAAACTCTACAAACT GAGATGTGGAAGGAAGGAAACAGAATTCATTTTCAAACCAAGGTCCAAGAAACTGGAGAC ATTGTCATTTCAAATGCATATGTGGATCTTGCACCAACATCTGGTACTTCAGCTAAGACA CCCTCTGAGGGCGGGAAGCTTCAGAGTACCTTTGTATTTGAGGAAATAGGACGCCGCCTA AAGGATATTGGGCCTGAGGTGGTGAAGAAAGTAAATGCTGTATTTGAGTGGCATATAACC AAAGGCGGAAATATTGGGGCTAAGTGGACTATTGACCTGAAAAGTGGTTCTGGAAAAGTG TACCAAGGCCCTGCAAAAGGTGCTGCTGATACAACAATCATACTTTCAGATGAAGATTTC ATGGAGGTGGTCCTGGGCAAGCTTGACCCTCAGAAGGCATTCTTTAGTGGCAGGCTGAAG GCCAGAGGGAACATCATGCTGAGCCAGAAACTTCAGATGATTCTTAAAGACTACGCCAAG CTCTGA
- Chromosome Location
- 5
- Locus
- 5q21
- External Identifiers
Resource Link UniProtKB ID P51659 UniProtKB Entry Name DHB4_HUMAN GenBank Protein ID 1050517 GenBank Gene ID X87176 GenAtlas ID HSD17B4 HGNC ID HGNC:5213 - General References
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