Cationic amino acid transporter 2
Details
- Name
- Cationic amino acid transporter 2
- Synonyms
- ATRC2
- CAT-2
- CAT2
- Low affinity cationic amino acid transporter 2
- Solute carrier family 7 member 2
- Gene Name
- SLC7A2
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0037048|Cationic amino acid transporter 2 MIPCRAALTFARCLIRRKIVTLDSLEDTKLCRCLSTMDLIALGVGSTLGAGVYVLAGEVA KADSGPSIVVSFLIAALASVMAGLCYAEFGARVPKTGSAYLYTYVTVGELWAFITGWNLI LSYVIGTSSVARAWSGTFDELLSKQIGQFLRTYFRMNYTGLAEYPDFFAVCLILLLAGLL SFGVKESAWVNKVFTAVNILVLLFVMVAGFVKGNVANWKISEEFLKNISASAREPPSENG TSIYGAGGFMPYGFTGTLAGAATCFYAFVGFDCIATTGEEVRNPQKAIPIGIVTSLLVCF MAYFGVSAALTLMMPYYLLDEKSPLPVAFEYVGWGPAKYVVAAGSLCALSTSLLGSIFPM PRVIYAMAEDGLLFKCLAQINSKTKTPIIATLSSGAVAALMAFLFDLKALVDMMSIGTLM AYSLVAACVLILRYQPGLSYDQPKCSPEKDGLGSSPRVTSKSESQVTMLQRQGFSMRTLF CPSLLPTQQSASLVSFLVGFLAFLVLGLSVLTTYGVHAITRLEAWSLALLALFLVLFVAI VLTIWRQPQNQQKVAFMVPFLPFLPAFSILVNIYLMVQLSADTWVRFSIWMAIGFLIYFS YGIRHSLEGHLRDENNEEDAYPDNVHAAAEEKSAIQANDHHPRNLSSPFIFHEKTSEF
- Number of residues
- 658
- Molecular Weight
- 71672.175
- Theoretical pI
- 7.55
- GO Classification
- Functionsantiporter activity / arginine transmembrane transporter activity / basic amino acid transmembrane transporter activity / high-affinity arginine transmembrane transporter activity / high-affinity L-ornithine transmembrane transporter activity / high-affinity lysine transmembrane transporter activity / L-lysine transmembrane transporter activity / L-ornithine transmembrane transporter activity / low-affinity L-arginine transmembrane transporter activityProcessesamino acid transport / basic amino acid transmembrane transport / cellular amino acid metabolic process / ion transport / L-arginine import across plasma membrane / L-lysine import across plasma membrane / L-lysine transmembrane transport / L-ornithine import across plasma membrane / L-ornithine transmembrane transport / macrophage activation / nitric oxide biosynthetic process / nitric oxide production involved in inflammatory response / regulation of inflammatory response / regulation of macrophage activation / transmembrane transport / transportComponentsintegral component of plasma membrane / membrane / plasma membrane
- General Function
- Low-affinity l-arginine transmembrane transporter activity
- Specific Function
- Functions as permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine); the affinity for its substrates differs between isoforms created by alternative splicing. Isoform 1 functions as permease that mediates the transport of the cationic amino acids (arginine, lysine and ornithine), and it has much higher affinity for arginine than isoform 2. Isoform 2 functions as low-affinity, high capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine) (PubMed:9174363). May play a role in classical or alternative activation of macrophages via its role in arginine transport.
- Pfam Domain Function
- Transmembrane Regions
- 38-59 64-84 105-125 164-184 193-213 249-269 290-309 340-360 387-407 411-431 491-511 525-549 558-578 583-603
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0010390|Cationic amino acid transporter 2 (SLC7A2) ATGATTCCTTGCAGAGCCGCGCTGACCTTTGCCCGATGTCTGATCCGGAGAAAAATCGTG ACCCTGGACAGTCTAGAAGACACCAAATTATGCCGCTGCTTATCCACCATGGACCTCATT GCCCTGGGCGTTGGAAGCACCCTTGGGGCCGGGGTTTATGTCCTCGCTGGGGAGGTGGCC AAGGCAGACTCGGGCCCCAGCATCGTGGTGTCCTTCCTCATTGCTGCCCTGGCTTCAGTG ATGGCTGGCCTCTGCTATGCCGAATTTGGGGCCCGTGTTCCCAAGACGGGGTCTGCATAT TTGTACACCTACGTGACTGTCGGAGAGCTGTGGGCCTTCATCACTGGCTGGAATCTCATT TTATCGTATGTGATAGGTACATCAAGTGTTGCAAGAGCCTGGAGTGGCACCTTTGATGAA CTTCTTAGCAAACAGATTGGTCAGTTTTTGAGGACATACTTCAGAATGAATTACACTGGT CTTGCAGAATATCCCGATTTTTTTGCTGTGTGCCTTATATTACTTCTAGCAGGTCTTTTG TCTTTTGGAGTAAAAGAGTCTGCTTGGGTGAATAAAGTCTTCACAGCTGTTAATATTCTC GTCCTTCTGTTTGTGATGGTTGCTGGGTTTGTGAAAGGAAATGTGGCAAACTGGAAGATT AGTGAAGAGTTTCTCAAAAATATATCAGCAAGTGCCAGAGAGCCACCTTCTGAAAACGGA ACAAGTATCTATGGGGCTGGTGGCTTTATGCCTTATGGCTTTACGGGAACGTTGGCTGGT GCTGCAACTTGCTTTTATGCCTTTGTGGGATTTGACTGCATTGCAACAACTGGTGAAGAA GTTCGGAATCCCCAGAAAGCTATTCCCATTGGAATTGTGACGTCTTTGCTTGTTTGCTTT ATGGCCTATTTTGGGGTCTCTGCAGCTTTAACACTTATGATGCCGTACTACCTCCTCGAT GAAAAAAGCCCCCTTCCTGTAGCGTTTGAATATGTGGGATGGGGTCCTGCCAAATATGTC GTCGCAGCTGGTTCTCTCTGCGCCTTGTCAACAAGTCTTCTTGGATCCATTTTCCCAATG CCTCGTGTAATCTATGCTATGGCGGAGGATGGGTTGCTTTTCAAATGTCTAGCTCAAATC AATTCCAAAACGAAGACACCAATAATTGCTACTTTATCATCGGGTGCAGTGGCAGCTTTG ATGGCCTTTCTGTTTGACCTGAAGGCGCTTGTGGACATGATGTCCATTGGCACACTCATG GCCTACTCTCTGGTGGCAGCCTGTGTTCTCATCCTCAGGTACCAGCCTGGCTTATCTTAC GACCAGCCCAAATGTTCTCCTGAGAAAGATGGTCTGGGATCGTCTCCCAGGGTAACCTCG AAGAGTGAGTCCCAGGTCACCATGCTGCAGAGACAGGGCTTCAGCATGCGGACCCTCTTC TGCCCCTCCCTTCTGCCAACACAGCAGTCAGCTTCTCTCGTGAGCTTTCTGGTAGGATTC CTAGCTTTCCTCGTGTTGGGCCTGAGTGTCTTGACCACTTACGGAGTTCATGCCATCACC AGGCTGGAGGCCTGGAGCCTCGCTCTCCTCGCGCTGTTTCTTGTTCTCTTCGTTGCCATC GTTCTCACCATCTGGAGGCAGCCCCAGAATCAGCAAAAAGTAGCCTTCATGGTTCCATTC TTACCATTTTTGCCAGCGTTCAGCATCTTGGTGAACATTTACTTGATGGTCCAGTTAAGT GCAGACACTTGGGTCAGATTCAGCATTTGGATGGCAATTGGCTTCCTGATTTACTTTTCT TATGGCATTAGACACAGCCTGGAGGGTCATCTGAGAGATGAAAACAATGAAGAAGATGCT TATCCAGACAACGTTCATGCAGCAGCAGAAGAAAAATCTGCCATTCAAGCAAATGACCAT CACCCAAGAAATCTCAGTTCACCTTTCATATTCCATGAAAAGACAAGTGAATTCTAA
- Chromosome Location
- 8
- Locus
- 8p22-p21.3
- External Identifiers
Resource Link UniProtKB ID P52569 UniProtKB Entry Name CTR2_HUMAN GenBank Protein ID 849051 GenBank Gene ID D29990 GenAtlas ID SLC7A2 HGNC ID HGNC:11060 - General References
- Hoshide R, Ikeda Y, Karashima S, Matsuura T, Komaki S, Kishino T, Niikawa N, Endo F, Matsuda I: Molecular cloning, tissue distribution, and chromosomal localization of human cationic amino acid transporter 2 (HCAT2). Genomics. 1996 Dec 1;38(2):174-8. [Article]
- Closs EI, Graf P, Habermeier A, Cunningham JM, Forstermann U: Human cationic amino acid transporters hCAT-1, hCAT-2A, and hCAT-2B: three related carriers with distinct transport properties. Biochemistry. 1997 May 27;36(21):6462-8. [Article]
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