Adenylate kinase 2, mitochondrial
Details
- Name
- Adenylate kinase 2, mitochondrial
- Synonyms
- 2.7.4.3
- Adenylate monophosphate kinase
- ADK2
- AK 2
- ATP-AMP transphosphorylase 2
- ATP:AMP phosphotransferase
- Gene Name
- AK2
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0009398|Adenylate kinase 2, mitochondrial MAPSVPAAEPEYPKGIRAVLLGPPGAGKGTQAPRLAENFCVCHLATGDMLRAMVASGSEL GKKLKATMDAGKLVSDEMVVELIEKNLETPLCKNGFLLDGFPRTVRQAEMLDDLMEKRKE KLDSVIEFSIPDSLLIRRITGRLIHPKSGRSYHEEFNPPKEPMKDDITGEPLIRRSDDNE KALKIRLQAYHTQTTPLIEYYRKRGIHSAIDASQTPDVVFASILAAFSKATCKDLVMFI
- Number of residues
- 239
- Molecular Weight
- 26477.44
- Theoretical pI
- Not Available
- GO Classification
- Functionsadenylate kinase activity / ATP bindingProcessesADP biosynthetic process / AMP metabolic process / ATP metabolic process / nucleobase-containing small molecule interconversion / nucleobase-containing small molecule metabolic process / nucleotide phosphorylation / small molecule metabolic processComponentsextracellular exosome / mitochondrial inner membrane / mitochondrial intermembrane space / sperm mitochondrial sheath
- General Function
- Atp binding
- Specific Function
- Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis.
- Pfam Domain Function
- ADK_lid (PF05191)
- Transmembrane Regions
- Not Available
- Cellular Location
- Mitochondrion intermembrane space
- Gene sequence
>lcl|BSEQ0017449|Adenylate kinase 2, mitochondrial (AK2) ATGGCTCCCAGCGTGCCAGCGGCAGAACCCGAGTATCCTAAAGGCATCCGGGCCGTGCTG CTGGGGCCTCCCGGGGCCGGTAAAGGGACCCAGGCACCCAGATTGGCTGAAAACTTCTGT GTCTGCCATTTAGCTACTGGGGACATGCTGAGGGCCATGGTGGCTTCTGGCTCAGAGCTA GGAAAAAAGCTGAAGGCAACTATGGATGCTGGGAAACTGGTGAGTGATGAAATGGTAGTG GAGCTCATTGAGAAGAATTTGGAGACCCCCTTGTGCAAAAATGGTTTTCTTCTGGATGGC TTCCCTCGGACTGTGAGGCAGGCAGAAATGCTCGATGACCTCATGGAGAAGAGGAAAGAG AAGCTTGATTCTGTGATTGAATTCAGCATCCCAGACTCTCTGCTGATTCACCCCAAGAGT GGCCGTTCCTACCACGAGGAGTTCAACCCTCCAAAAGAGCCCATGAAAGATGACATCACC GGGGAACCCTTGATCCGTCGATCAGATGATAATGAAAAGGCCTTGAAAATCCGCCTGCAA GCCTACCACACTCAAACCACCCCACTCATAGAGTACTACAGGAAACGGGGGATCCACTCC GCCATCGATGCATCCCAGACCCCCGATGTCGTGTTCGCAAGCATCCTAGCAGCCTTCTCC AAAGCCACATCCTAG
- Chromosome Location
- 1
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P54819 UniProtKB Entry Name KAD2_HUMAN HGNC ID HGNC:362 - General References
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Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB01717 Bis(Adenosine)-5'-Pentaphosphate experimental unknown Details DB03366 Imidazole experimental, investigational unknown Details DB00300 Tenofovir disoproxil approved, investigational unknown substrate Details DB00718 Adefovir dipivoxil approved, investigational unknown substrate Details DB09299 Tenofovir alafenamide approved no substrate Details DB14126 Tenofovir experimental, investigational no substrate Details