Oxysterols receptor LXR-beta
Details
- Name
- Oxysterols receptor LXR-beta
- Synonyms
- Liver X receptor beta
- LXRB
- NER
- Nuclear receptor NER
- Nuclear receptor subfamily 1 group H member 2
- Ubiquitously-expressed nuclear receptor
- UNR
- Gene Name
- NR1H2
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0037145|Oxysterols receptor LXR-beta MSSPTTSSLDTPLPGNGPPQPGAPSSSPTVKEEGPEPWPGGPDPDVPGTDEASSACSTDW VIPDPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGA RRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQESQSQ SQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKR SFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQI ALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMR RLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRM LMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
- Number of residues
- 460
- Molecular Weight
- 50973.375
- Theoretical pI
- 7.8
- GO Classification
- Functionsapolipoprotein A-I receptor binding / ATPase binding / DNA binding / RNA polymerase II core promoter proximal region sequence-specific DNA binding / RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding / RNA polymerase II transcription factor activity, sequence-specific transcription regulatory region DNA binding / steroid hormone receptor activity / transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding / zinc ion bindingProcessescellular lipid metabolic process / cholesterol homeostasis / gene expression / negative regulation of cholesterol storage / negative regulation of interferon-gamma-mediated signaling pathway / negative regulation of lipid transport / negative regulation of macrophage derived foam cell differentiation / negative regulation of pinocytosis / negative regulation of proteolysis / negative regulation of transcription from RNA polymerase II promoter / negative regulation of transcription, DNA-templated / positive regulation of cellular protein metabolic process / positive regulation of cholesterol efflux / positive regulation of cholesterol transport / positive regulation of fatty acid biosynthetic process / positive regulation of high-density lipoprotein particle assembly / positive regulation of lipid storage / positive regulation of lipoprotein lipase activity / positive regulation of pancreatic juice secretion / positive regulation of secretion of lysosomal enzymes / positive regulation of transcription from RNA polymerase II promoter / positive regulation of transcription, DNA-templated / positive regulation of triglyceride biosynthetic process / regulation of cholesterol homeostasis / retinoic acid receptor signaling pathway / transcription initiation from RNA polymerase II promoterComponentscytoplasm / nucleoplasm / nucleus
- General Function
- Zinc ion binding
- Specific Function
- Nuclear receptor. Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity). Exhibits a ligand-dependent transcriptional activation activity (PubMed:25661920).
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Nucleus
- Gene sequence
>lcl|BSEQ0021844|Oxysterols receptor LXR-beta (NR1H2) ATGTCCTCTCCTACCACGAGTTCCCTGGATACCCCCCTGCCTGGAAATGGCCCCCCTCAG CCTGGCGCCCCTTCTTCTTCACCCACTGTAAAGGAGGAGGGTCCGGAGCCGTGGCCCGGG GGTCCGGACCCTGATGTCCCAGGCACTGATGAGGCCAGCTCAGCCTGCAGCACAGACTGG GGCGTCCTTTCTGAAGAACAGATCCGGAAGAAGAAGATTCGGAAACAACAGCAGCAGGAG TCACAGTCACAGTCGCAGTCACCTGTGGGGCCGCAGGGCAGCAGCAGCTCAGCCTCTGGG CCTGGGGCTTCCCCTGGTGGATCTGAGGCAGGCAGCCAGGGCTCCGGGGAAGGCGAGGGT GTCCAGCTAACAGCGGCTCAAGAACTAATGATCCAGCAGTTGGTGGCGGCCCAACTGCAG TGCAACAAACGCTCCTTCTCCGACCAGCCCAAAGTCACGCCCTGGCCCCTGGGCGCAGAC CCCCAGTCCCGAGATGCCCGCCAGCAACGCTTTGCCCACTTCACGGAGCTGGCCATCATC TCAGTCCAGGAGATCGTGGACTTCGCTAAGCAAGTGCCTGGTTTCCTGCAGCTGGGCCGG GAGGACCAGATCGCCCTCCTGAAGGCATCCACTATCGAGATCATGCTGCTAGAGACAGCC AGGCGCTACAACCACGAGACAGAGTGTATCACCTTCTTGAAGGACTTCACCTACAGCAAG GACGACTTCCACCGTGCAGGCCTGCAGGTGGAGTTCATCAACCCCATCTTCGAGTTCTCG CGGGCCATGCGGCGGCTGGGCCTGGACGACGCTGAGTACGCCCTGCTCATCGCCATCAAC ATCTTCTCGGCCGACCGGCCCAACGTGCAGGAGCCGGGCCGCGTGGAGGCGTTGCAGCAG CCCTACGTGGAGGCGCTGCTGTCCTACACGCGCATCAAGAGGCCGCAGGACCAGCTGCGC TTCCCGCGCATGCTCATGAAGCTGGTGAGCCTGCGCACGCTGAGCTCTGTGCACTCGGAG CAGGTCTTCGCCTTGCGGCTCCAGGACAAGAAGCTGCCGCCTCTGCTGTCGGAGATCTGG GACGTCCACGAGTGA
- Chromosome Location
- 19
- Locus
- 19q13.3-19q13.3
- External Identifiers
Resource Link UniProtKB ID P55055 UniProtKB Entry Name NR1H2_HUMAN GenBank Protein ID 641962 GenBank Gene ID U07132 GenAtlas ID NR1H2 HGNC ID HGNC:7965 - General References
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Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB03791 GW-3965 experimental unknown Details DB03848 Benzenesulfinic acid experimental unknown Details DB07080 TO-901317 experimental unknown Details DB07082 1,1,1,3,3,3-HEXAFLUORO-2-{4-[(2,2,2-TRIFLUOROETHYL)AMINO]PHENYL}PROPAN-2-OL experimental unknown Details DB13174 Rhein experimental unknown inhibitor Details DB11994 Diacerein approved, investigational unknown inhibitor Details