Penicillin-binding protein 2X
Details
- Name
- Penicillin-binding protein 2X
- Synonyms
- PBP-2X
- Gene Name
- pbpX
- Organism
- Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
- Amino acid sequence
>lcl|BSEQ0011338|Penicillin-binding protein 2X MKWTKRVIRYATKNRKSPAENRRRVGKSLSLLSVFVFAIFLVNFAVIIGTGTRFGTDLAK EAKKVHQTTRTVPAKRGTIYDRNGVPIAEDATSYNVYAVIDENYKSATGKILYVEKTQFN KVAEVFHKYLDMEESYVREQLSQPNLKQVSFGAKGNGITYANMMSIKKELEAAEVKGIDF TTSPNRSYPNGQFASSFIGLAQLHENEDGSKSLLGTSGMESSLNSILAGTDGIITYEKDR LGNIVPGTEQVSQRTMDGKDVYTTISSPLQSFMETQMDAFQEKVKGKYMTATLVSAKTGE ILATTQRPTFDADTKEGITEDFVWRDILYQSNYEPGSTMKVMMLAAAIDNNTFPGGEVFN SSELKIADATIRDWDVNEGLTGGRMMTFSQGFAHSSNVGMTLLEQKMGDATWLDYLNRFK FGVPTRFGLTDEYAGQLPADNIVNIAQSSFGQGISVTQTQMIRAFTAIANDGVMLEPKFI SAIYDPNDQTARKSQKEIVGNPVSKDAASLTRTNMVLVGTDPVYGTMYNHSTGKPTVTVP GQNVALKSGTAQIADEKNGGYLVGLTDYIFSAVSMSPAENPDFILYVTVQQPEHYSGIQL GEFANPILERASAMKDSLNLQTTAKALEQVSQQSPYPMPSVKDISPGDLAEELRRNLVQP IVVGTGTKIKNSSAEEGKNLAPNQQVLILSDKAEEVPDMYGWTKETAETLAKWLNIELEF QGSGSTVQKQDVRANTAIKDIKKITLTLGD
- Number of residues
- 750
- Molecular Weight
- 82342.565
- Theoretical pI
- 5.53
- GO Classification
- Functionspenicillin bindingProcessescell cycle / cell division / cell wall organization / peptidoglycan biosynthetic process / regulation of cell shape / response to antibioticComponentsintegral component of membrane / plasma membrane
- General Function
- Penicillin binding
- Specific Function
- Penicillin-binding proteins (PBPs) function in the late steps of murein biosynthesis. Beta-lactams inactivate the PBPs by acylating an essential serine residue in the active site of these proteins.
- Pfam Domain Function
- Transmembrane Regions
- 29-49
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0011339|Penicillin-binding protein 2X (pbpX) ATGAAGTGGACAAAAAGAGTAATCCGTTATGCGACCAAAAATCGGAAATCGCCGGCTGAA AACAGACGCAGAGTTGGAAAAAGTCTGAGTTTATTATCTGTCTTTGTTTTTGCCATTTTT TTAGTCAATTTTGCGGTCATTATTGGGACAGGCACTCGCTTTGGAACAGATTTAGCGAAG GAAGCTAAGAAGGTTCATCAAACCACCCGTACAGTTCCTGCCAAACGTGGGACTATTTAT GACCGAAATGGAGTCCCGATTGCTGAGGATGCAACCTCTTATAATGTCTATGCGGTCATT GATGAGAACTATAAGTCAGCAACGGGTAAGATTCTTTACGTAGAAAAAACACAATTTAAC AAGGTTGCAGAGGTCTTTCATAAGTATCTGGACATGGAAGAATCCTATGTAAGAGAGCAA CTCTCGCAACCTAATCTCAAGCAAGTTTCCTTTGGAGCAAAGGGAAATGGGATTACCTAT GCCAATATGATGTCTATCAAAAAAGAATTGGAAGCTGCAGAGGTCAAGGGGATTGATTTT ACAACCAGTCCCAATCGTAGTTACCCAAACGGACAATTTGCTTCTAGTTTTATCGGCCTA GCTCAGCTCCATGAAAATGAAGATGGAAGCAAGAGCTTGCTGGGAACCTCTGGAATGGAG AGTTCCTTGAACAGTATTCTTGCAGGGACAGACGGCATTATTACCTATGAAAAGGATCGT CTGGGTAATATTGTACCCGGAACAGAACAAGTTTCCCAACGAACGATGGACGGTAAGGAT GTTTATACAACCATTTCCAGCCCCCTCCAGTCCTTTATGGAAACCCAGATGGATGCTTTT CAAGAGAAGGTAAAAGGAAAGTACATGACAGCGACTTTGGTCAGTGCTAAAACAGGGGAA ATTCTGGCAACAACGCAACGACCGACCTTTGATGCAGATACAAAAGAAGGCATTACAGAG GACTTTGTTTGGCGTGATATCCTTTACCAAAGTAACTATGAGCCAGGTTCCACTATGAAA GTGATGATGTTGGCTGCTGCTATTGATAATAATACCTTTCCAGGAGGAGAAGTCTTTAAT AGTAGTGAGTTAAAAATTGCAGATGCCACGATTCGAGATTGGGACGTTAATGAAGGATTG ACTGGTGGCAGAATGATGACTTTTTCTCAAGGTTTTGCACACTCAAGTAACGTTGGGATG ACCCTCCTTGAGCAAAAGATGGGAGATGCTACCTGGCTTGATTATCTTAATCGTTTTAAA TTTGGTGTTCCGACCCGTTTCGGTTTGACGGATGAGTATGCTGGTCAGCTTCCTGCGGAT AATATTGTCAACATTGCGCAAAGCTCATTTGGACAAGGGATTTCAGTGACCCAGACGCAA ATGATTCGTGCCTTTACAGCTATTGCTAATGACGGTGTCATGCTGGAGCCTAAATTTATT AGTGCCATTTATGATCCAAATGATCAAACTGCTCGGAAATCTCAAAAAGAAATTGTGGGA AATCCTGTTTCTAAAGATGCAGCTAGTCTAACTCGGACTAACATGGTTTTGGTAGGGACG GATCCGGTTTATGGAACCATGTATAACCACAGCACAGGCAAGCCAACTGTAACTGTTCCT GGGCAAAATGTAGCCCTCAAGTCTGGTACGGCTCAGATTGCTGACGAGAAAAATGGTGGT TATCTAGTCGGGTTAACCGACTATATTTTCTCGGCTGTATCGATGAGTCCGGCTGAAAAT CCTGATTTTATCTTGTATGTGACGGTCCAACAACCTGAACATTATTCAGGTATTCAGTTG GGAGAATTTGCCAATCCTATCTTGGAGCGGGCTTCAGCTATGAAAGACTCTCTCAATCTT CAAACAACAGCTAAGGCTTTGGAGCAAGTAAGTCAACAAAGTCCTTATCCTATGCCCAGT GTCAAGGATATTTCACCTGGTGATTTAGCAGAAGAATTGCGTCGCAATCTTGTACAACCC ATCGTTGTGGGAACAGGAACGAAGATTAAAAACAGTTCTGCTGAAGAAGGGAAGAATCTT GCCCCGAACCAGCAAGTCCTTATCTTATCTGATAAAGCAGAGGAGGTTCCAGATATGTAT GGTTGGACAAAGGAGACTGCTGAGACCCTTGCTAAGTGGCTCAATATAGAACTTGAATTT CAAGGCTCGGGCTCTACTGTGCAGAAGCAAGATGTTCGTGCTAACACAGCTATCAAGGAC ATTAAAAAAATTACATTAACTTTAGGAGACTAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P59676 UniProtKB Entry Name PBPX_STRR6 GenBank Protein ID 47392 GenBank Gene ID X16367 - General References
- Laible G, Hakenbeck R, Sicard MA, Joris B, Ghuysen JM: Nucleotide sequences of the pbpX genes encoding the penicillin-binding proteins 2x from Streptococcus pneumoniae R6 and a cefotaxime-resistant mutant, C506. Mol Microbiol. 1989 Oct;3(10):1337-48. [Article]
- Hoskins J, Alborn WE Jr, Arnold J, Blaszczak LC, Burgett S, DeHoff BS, Estrem ST, Fritz L, Fu DJ, Fuller W, Geringer C, Gilmour R, Glass JS, Khoja H, Kraft AR, Lagace RE, LeBlanc DJ, Lee LN, Lefkowitz EJ, Lu J, Matsushima P, McAhren SM, McHenney M, McLeaster K, Mundy CW, Nicas TI, Norris FH, O'Gara M, Peery RB, Robertson GT, Rockey P, Sun PM, Winkler ME, Yang Y, Young-Bellido M, Zhao G, Zook CA, Baltz RH, Jaskunas SR, Rosteck PR Jr, Skatrud PL, Glass JI: Genome of the bacterium Streptococcus pneumoniae strain R6. J Bacteriol. 2001 Oct;183(19):5709-17. [Article]
Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB03190 6-o-Capryloylsucrose experimental unknown Details DB01147 Cloxacillin approved, investigational, vet_approved yes inhibitor Details DB14733 Ceftobiprole medocaril approved, experimental, investigational yes inhibitor Details DB04918 Ceftobiprole approved, investigational yes inhibitor Details