2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Details
- Name
- 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
- Synonyms
- 4.6.1.12
- MECDP-synthase
- Gene Name
- ispF
- Organism
- Shigella flexneri
- Amino acid sequence
>lcl|BSEQ0010908|2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase MRIGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKL FPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDL GCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKATK
- Number of residues
- 159
- Molecular Weight
- 16897.37
- Theoretical pI
- 6.51
- GO Classification
- Functions2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity / metal ion bindingProcessesisopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway / terpenoid biosynthetic process
- General Function
- Metal ion binding
- Specific Function
- Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
- Pfam Domain Function
- YgbB (PF02542)
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0010909|2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (ispF) ATGCGAATTGGACACGGTTTTGACGTACACGCCTTTGGCGGTGAAGGCCCAATTATCATT GGTGGCGTACGCATTCCTTACGAAAAAGGATTGCTGGCGCATTCTGATGGCGACGTGGCG CTTCATGCGTTGACCGATGCATTGCTTGGCGCGGCGGCGCTGGGGGATATCGGCAAACTG TTCCCGGATACCGATCCGGCATTTAAAGGTGCCGACAGCCGCGAGCTGCTACGCGAAGCC TGGCGTCGTATTCAGGCGAAGGGTTATACCCTTGGCAACGTCGATGTCACTATCATCGCT CAGGCACCGAAGATGTTGCCGCACATTCCACAAATGCGCGTGTTTATTGCCGAAGATCTC GGCTGCCATATGGATGATGTTAACGTGAAAGCCACTACTACGGAAAAACTTGGATTTACC GGACGTGGGGAAGGGATTGCCTGTGAAGCGGTGGCGCTACTCATTAAGGCAACAAAATGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P62619 UniProtKB Entry Name ISPF_SHIFL GenBank Protein ID 24053164 GenBank Gene ID AE005674 - General References
- Jin Q, Yuan Z, Xu J, Wang Y, Shen Y, Lu W, Wang J, Liu H, Yang J, Yang F, Zhang X, Zhang J, Yang G, Wu H, Qu D, Dong J, Sun L, Xue Y, Zhao A, Gao Y, Zhu J, Kan B, Ding K, Chen S, Cheng H, Yao Z, He B, Chen R, Ma D, Qiang B, Wen Y, Hou Y, Yu J: Genome sequence of Shigella flexneri 2a: insights into pathogenicity through comparison with genomes of Escherichia coli K12 and O157. Nucleic Acids Res. 2002 Oct 15;30(20):4432-41. [Article]
- Wei J, Goldberg MB, Burland V, Venkatesan MM, Deng W, Fournier G, Mayhew GF, Plunkett G 3rd, Rose DJ, Darling A, Mau B, Perna NT, Payne SM, Runyen-Janecky LJ, Zhou S, Schwartz DC, Blattner FR: Complete genome sequence and comparative genomics of Shigella flexneri serotype 2a strain 2457T. Infect Immun. 2003 May;71(5):2775-86. [Article]
Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB01859 4-CDP-2-C-methyl-D-erythritol 2-phosphate experimental unknown Details DB02552 Geranyl Diphosphate experimental unknown Details DB03403 Cytidine-5'-Monophosphate experimental unknown Details DB03687 4-(Cytidine 5'-diphospho)-2-C-methyl-D-erythritol experimental unknown Details DB03961 2c-Methyl-D-Erythritol 2,4-Cyclodiphosphate experimental unknown Details DB04555 Cytidine-5'-Diphosphate experimental unknown Details