Complement control protein C3
Details
- Name
- Complement control protein C3
- Synonyms
- 28 kDa protein
- Protein C3
- Secretory protein 35
- VCP
- Gene Name
- Not Available
- Organism
- VACV
- Amino acid sequence
>lcl|BSEQ0011024|Complement control protein C3 MKVESVTFLTLLGIGCVLSCCTIPSRPINMKFKNSVETDANANYNIGDTIEYLCLPGYRK QKMGPIYAKCTGTGWTLFNQCIKRRCPSPRDIDNGQLDIGGVDFGSSITYSCNSGYHLIG ESKSYCELGSTGSMVWNPEAPICESVKCQSPPSISNGRHNGYEDFYTDGSVVTYSCNSGY SLIGNSGVLCSGGEWSDPPTCQIVKCPHPTISNGYLSSGFKRSYSYNDNVDFKCKYGYKL SGSSSSTCSPGNTWKPELPKCVR
- Number of residues
- 263
- Molecular Weight
- 28629.03
- Theoretical pI
- 7.79
- GO Classification
- Processessuppression by virus of host complement activationComponentsextracellular region / host cell plasma membrane / integral component of membrane / virion membrane
- General Function
- Not Available
- Specific Function
- Serves to protect the virus against complement attack by inhibiting both classical and alternative pathways of complement activation. Binds C3b and C4b.
- Pfam Domain Function
- Sushi (PF00084)
- Transmembrane Regions
- Not Available
- Cellular Location
- Virion membrane
- Gene sequence
>lcl|BSEQ0011025|Complement control protein C3 ATGAAGGTGGAGAGCGTGACGTTCCTGACATTGTTGGGAATAGGATGCGTTCTATCATGC TGTACTATTCCGTCACGACCCATTAATATGAAATTTAAGAATAGTGTGGAGACTGATGCT AATGCTAATTACAACATAGGAGACACTATAGAATATCTATGTCTACCTGGATACAGAAAG CAAAAAATGGGACCTATATATGCTAAATGTACAGGTACTGGATGGACACTCTTTAATCAA TGTATTAAACGGAGATGCCCATCGCCTCGAGATATCGATAATGGCCAACTTGATATTGGT GGAGTAGACTTTGGCTCTAGTATAACGTACTCTTGTAATAGCGGATATCATTTGATCGGT GAATCTAAATCGTATTGTGAATTAGGATCTACTGGATCTATGGTATGGAATCCCGAGGCA CCTATTTGTGAATCTGTTAAATGCCAATCCCCTCCATCTATATCCAACGGAAGACATAAC GGATACGAGGATTTTTATACCGATGGGAGCGTTGTAACTTATAGTTGCAATAGTGGATAT TCGTTGATTGGTAACTCTGGTGTCCTGTGTTCAGGAGGAGAATGGTCCGATCCACCCACG TGTCAGATTGTTAAATGTCCACATCCTACAATATCAAACGGATACTTGTCTAGCGGGTTT AAAAGATCATACTCATACAACGACAATGTAGACTTTAAGTGCAAGTACGGATATAAACTA TCTGGTTCCTCATCATCTACTTGCTCTCCAGGAAATACATGGAAGCCGGAACTTCCAAAA TGTGTACGCTAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P68638 UniProtKB Entry Name VCP_VACCW GenBank Protein ID 60691 GenBank Gene ID X13166 - General References
- Kotwal GJ, Moss B: Vaccinia virus encodes a secretory polypeptide structurally related to complement control proteins. Nature. 1988 Sep 8;335(6186):176-8. [Article]
- Kotwal GJ, Moss B: Analysis of a large cluster of nonessential genes deleted from a vaccinia virus terminal transposition mutant. Virology. 1988 Dec;167(2):524-37. [Article]
- Isaacs SN, Kotwal GJ, Moss B: Vaccinia virus complement-control protein prevents antibody-dependent complement-enhanced neutralization of infectivity and contributes to virulence. Proc Natl Acad Sci U S A. 1992 Jan 15;89(2):628-32. [Article]
- Girgis NM, Dehaven BC, Fan X, Viner KM, Shamim M, Isaacs SN: Cell surface expression of the vaccinia virus complement control protein is mediated by interaction with the viral A56 protein and protects infected cells from complement attack. J Virol. 2008 May;82(9):4205-14. doi: 10.1128/JVI.02426-07. Epub 2008 Feb 20. [Article]
- DeHaven BC, Girgis NM, Xiao Y, Hudson PN, Olson VA, Damon IK, Isaacs SN: Poxvirus complement control proteins are expressed on the cell surface through an intermolecular disulfide bridge with the viral A56 protein. J Virol. 2010 Nov;84(21):11245-54. doi: 10.1128/JVI.00372-10. Epub 2010 Aug 18. [Article]
- Dehaven BC, Gupta K, Isaacs SN: The vaccinia virus A56 protein: a multifunctional transmembrane glycoprotein that anchors two secreted viral proteins. J Gen Virol. 2011 Sep;92(Pt 9):1971-80. doi: 10.1099/vir.0.030460-0. Epub 2011 Jun 29. [Article]
- Wiles AP, Shaw G, Bright J, Perczel A, Campbell ID, Barlow PN: NMR studies of a viral protein that mimics the regulators of complement activation. J Mol Biol. 1997 Sep 19;272(2):253-65. [Article]