Aromatic-amino-acid aminotransferase
Details
- Name
- Aromatic-amino-acid aminotransferase
- Synonyms
- 2.6.1.57
- ARAT
- Gene Name
- tyrB
- Organism
- Paracoccus denitrificans
- Amino acid sequence
>lcl|BSEQ0010973|Aromatic-amino-acid aminotransferase MLGNLKPQAPDKILALMGEFRADPRQGKIDLGVGVYKDATGHTPIMRAVHAAEQRMLETE TTKTYAGLSGEPEFQKAMGELILGDGLKSETTATLATVGGTGALRQALELARMANPDLRV FVSDPTWPNHVSIMNFMGLPVQTYRYFDAETRGVDFEGMKADLAAAKKGDMVLLHGCCHN PTGANLTLDQWAEIASILEKTGALPLIDLAYQGFGDGLEEDAAGTRLIASRIPEVLIAAS CSKNFGIYRERTGCLLALCADAATRELAQGAMAFLNRQTYSFPPFHGAKIVSTVLTTPEL RADWMAELEAVRSGMLRLREQLAGELRDLSGSDRFGFVAEHRGMFSRLGATPEQVKRIKE EFGIYMVGDSRINIAGLNDNTIPILARAIIEVGV
- Number of residues
- 394
- Molecular Weight
- 42731.635
- Theoretical pI
- 5.49
- GO Classification
- Functionsaromatic-amino-acid / L-phenylalanine / pyridoxal phosphate bindingProcessesaromatic amino acid family biosynthetic processComponentscytoplasm
- General Function
- Pyridoxal phosphate binding
- Specific Function
- Shows activities toward both dicarboxylic and aromatic substrates.
- Pfam Domain Function
- Aminotran_1_2 (PF00155)
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0002756|1185 bp ATGCTGGGCAATCTGAAACCGCAGGCCCCCGACAAGATCCTGGCCCTGATGGGCGAATTC AGGGCCGATCCCCGCCAGGGCAAGATCGACCTGGGCGTGGGGGTCTACAAGGATGCCACC GGCCACACCCCGATCATGCGGGCCGTCCACGCCGCCGAGCAGCGCATGCTGGAAACCGAG ACCACCAAGACCTATGCCGGCCTCTCGGGCGAGCCCGAGTTCCAAAAGGCCATGGGCGAG CTGATCCTGGGCGACGGACTGAAATCCGAGACCACCGCGACGCTGGCGACGGTCGGCGGC ACCGGCGCCCTCCGGCAGGCGCTGGAACTGGCGCGCATGGCGAACCCGGACCTGCGGGTC TTCGTCAGCGATCCGACCTGGCCGAACCATGTCTCGATCATGAATTTCATGGGCCTGCCG GTGCAGACCTATCGCTATTTCGATGCCGAGACCCGCGGCGTCGATTTCGAGGGCATGAAG GCCGACCTCGCCGCCGCGAAAAAGGGCGACATGGTGCTGCTGCACGGCTGCTGCCACAAC CCGACCGGCGCCAACCTGACGCTGGATCAATGGGCCGAGATCGCCTCGATCCTGGAAAAG ACCGGCGCGCTGCCGCTGATCGACCTGGCCTATCAGGGCTTCGGCGACGGGCTGGAAGAG GACGCGGCCGGCACCCGGCTGATCGCCTCGCGCATCCCCGAGGTGCTGATCGCGGCCTCG TGCAGCAAGAACTTCGGCATCTACCGCGAACGCACCGGCTGCCTGCTGGCGCTTTGCGCC GATGCGGCGACCAGGGAGCTGGCGCAGGGCGCCATGGCCTTCCTGAACCGCCAGACCTAT TCCTTCCCGCCCTTCCACGGCGCCAAGATCGTCTCGACCGTGCTGACCACGCCCGAACTG CGCGCCGACTGGATGGCCGAGCTGGAAGCGGTGCGCAGCGGCATGCTGCGCCTGCGCGAG CAATTGGCGGGCGAGTTGCGCGATCTCAGCGGTTCGGACCGTTTCGGCTTCGTGGCCGAG CATCGCGGCATGTTCTCGCGCCTGGGCGCCACGCCCGAACAGGTCAAGCGCATCAAGGAA GAGTTCGGCATCTACATGGTGGGCGATTCGCGCATCAACATCGCCGGGCTGAACGACAAC ACCATCCCGATCCTGGCCCGCGCTATCATCGAGGTGGGGGTCTAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P95468 UniProtKB Entry Name TYRB_PARDE GenBank Protein ID 1806263 GenBank Gene ID Y08272 - General References
- Oue S, Okamoto A, Nakai Y, Nakahira M, Shibatani T, Hayashi H, Kagamiyama H: Paracoccus denitrificans aromatic amino acid aminotransferase: a model enzyme for the study of dual substrate recognition mechanism. J Biochem. 1997 Jan;121(1):161-71. [Article]
- Okamoto A, Nakai Y, Hayashi H, Hirotsu K, Kagamiyama H: Crystal structures of Paracoccus denitrificans aromatic amino acid aminotransferase: a substrate recognition site constructed by rearrangement of hydrogen bond network. J Mol Biol. 1998 Jul 17;280(3):443-61. [Article]
- Okamoto A, Ishii S, Hirotsu K, Kagamiyama H: The active site of Paracoccus denitrificans aromatic amino acid aminotransferase has contrary properties: flexibility and rigidity. Biochemistry. 1999 Jan 26;38(4):1176-84. [Article]
Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB06819 Phenylbutyric acid approved, investigational unknown Details DB02024 3-phenylpropionic acid experimental unknown Details DB02242 Cyclohexanepropanoic acid experimental unknown Details DB02434 4-(2-Thienyl)Butyric Acid experimental unknown Details DB02740 3-Indolebutyric Acid experimental unknown Details DB02758 Indolepropionic acid experimental unknown Details DB03210 4-Aminohydrocinnamic Acid experimental unknown Details DB03400 3-(P-Tolyl)Propionic Acid experimental unknown Details DB04051 5-phenylpentanoic acid experimental unknown Details DB04208 3-(3,4-dimethoxyphenyl)propanoic acid experimental unknown Details DB04299 Maleic acid experimental unknown Details