Purine nucleoside phosphorylase
Details
- Name
- Purine nucleoside phosphorylase
- Synonyms
- 2.4.2.1
- deoD
- Inosine phosphorylase
- Inosine-guanosine phosphorylase
- PNP
- Gene Name
- punA
- Organism
- Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
- Amino acid sequence
>lcl|BSEQ0051177|Purine nucleoside phosphorylase MADPRPDPDELARRAAQVIADRTGIGEHDVAVVLGSGWLPAVAALGSPTTVLPQAELPGF VPPTAAGHAGELLSVPIGAHRVLVLAGRIHAYEGHDLRYVVHPVRAARAAGAQIMVLTNA AGGLRADLQVGQPVLISDHLNLTARSPLVGGEFVDLTDAYSPRLRELARQSDPQLAEGVY AGLPGPHYETPAEIRMLQTLGADLVGMSTVHETIAARAAGAEVLGVSLVTNLAAGITGEP LSHAEVLAAGAASATRMGALLADVIARF
- Number of residues
- 268
- Molecular Weight
- 27571.215
- Theoretical pI
- Not Available
- GO Classification
- Functionspurine-nucleoside phosphorylase activityProcessesdeoxyguanosine catabolic process
- General Function
- The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. Cleaves guanosine, inosine, 2'-deoxyguanosine and 2'-deoxyinosine.
- Specific Function
- Purine-nucleoside phosphorylase activity
- Pfam Domain Function
- PNP_UDP_1 (PF01048)
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0051178|Purine nucleoside phosphorylase (punA) GTGGCTGACCCGCGCCCCGATCCCGACGAACTGGCCCGGCGGGCGGCGCAGGTCATCGCT GACCGCACCGGGATCGGCGAACATGACGTCGCGGTCGTGCTCGGGTCGGGATGGTTACCG GCCGTTGCGGCGTTGGGCTCCCCGACCACCGTGCTGCCGCAGGCCGAACTGCCCGGGTTT GTGCCGCCAACCGCAGCCGGGCATGCGGGCGAGCTACTGTCCGTGCCCATCGGTGCGCAC CGGGTGCTGGTGCTGGCCGGTCGCATCCACGCCTACGAGGGACACGACCTGCGCTACGTC GTGCATCCGGTTCGGGCGGCCCGTGCGGCAGGGGCGCAGATTATGGTGCTCACCAACGCC GCCGGTGGGCTGCGGGCGGACCTTCAGGTCGGCCAGCCGGTGCTGATCAGCGATCACCTG AACCTGACCGCACGTTCGCCACTGGTTGGCGGGGAGTTCGTCGACCTGACCGACGCCTAC TCACCGCGACTGCGGGAACTCGCCCGCCAATCCGACCCGCAGCTGGCCGAAGGCGTCTAC GCCGGCCTGCCGGGGCCGCACTACGAGACACCGGCGGAGATCCGGATGTTGCAGACACTG GGCGCCGACCTGGTCGGCATGTCCACGGTGCACGAGACCATCGCGGCCCGGGCGGCGGGC GCTGAGGTACTGGGCGTATCCCTGGTGACAAATCTGGCGGCCGGGATCACCGGCGAGCCG CTGAGCCACGCCGAGGTGCTCGCCGCCGGAGCCGCATCGGCGACTCGGATGGGCGCGCTG CTAGCCGACGTGATCGCCCGGTTCTAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P9WP01 UniProtKB Entry Name PUNA_MYCTU - General References
- Cole ST, Brosch R, Parkhill J, Garnier T, Churcher C, Harris D, Gordon SV, Eiglmeier K, Gas S, Barry CE 3rd, Tekaia F, Badcock K, Basham D, Brown D, Chillingworth T, Connor R, Davies R, Devlin K, Feltwell T, Gentles S, Hamlin N, Holroyd S, Hornsby T, Jagels K, Krogh A, McLean J, Moule S, Murphy L, Oliver K, Osborne J, Quail MA, Rajandream MA, Rogers J, Rutter S, Seeger K, Skelton J, Squares R, Squares S, Sulston JE, Taylor K, Whitehead S, Barrell BG: Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature. 1998 Jun 11;393(6685):537-44. [Article]
- Kelkar DS, Kumar D, Kumar P, Balakrishnan L, Muthusamy B, Yadav AK, Shrivastava P, Marimuthu A, Anand S, Sundaram H, Kingsbury R, Harsha HC, Nair B, Prasad TS, Chauhan DS, Katoch K, Katoch VM, Kumar P, Chaerkady R, Ramachandran S, Dash D, Pandey A: Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry. Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3. [Article]
- Shi W, Basso LA, Santos DS, Tyler PC, Furneaux RH, Blanchard JS, Almo SC, Schramm VL: Structures of purine nucleoside phosphorylase from Mycobacterium tuberculosis in complexes with immucillin-H and its pieces. Biochemistry. 2001 Jul 27;40(28):8204-15. [Article]
Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB03411 2-Hydroxymethyl-Pyrrolidine-3,4-Diol experimental unknown Details DB03551 (3R,4R)-3-Hydroxy-4-(hydroxymethyl)-1-[(4-oxo-4,4a,5,7a-tetrahydro-3H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]pyrrolidinium experimental unknown Details DB04095 9-Deazahypoxanthine experimental unknown Details