Mycocyclosin synthase
Details
- Name
- Mycocyclosin synthase
- Synonyms
- 1.14.21.9
- Cytochrome P450 121
- Cytochrome P450 MT2
- Gene Name
- cyp121
- Organism
- Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
- Amino acid sequence
>lcl|BSEQ0051128|Mycocyclosin synthase MTATVLLEVPFSARGDRIPDAVAELRTREPIRKVRTITGAEAWLVSSYALCTQVLEDRRF SMKETAAAGAPRLNALTVPPEVVNNMGNIADAGLRKAVMKAITPKAPGLEQFLRDTANSL LDNLITEGAPADLRNDFADPLATALHCKVLGIPQEDGPKLFRSLSIAFMSSADPIPAAKI NWDRDIEYMAGILENPNITTGLMGELSRLRKDPAYSHVSDELFATIGVTFFGAGVISTGS FLTTALISLIQRPQLRNLLHEKPELIPAGVEELLRINLSFADGLPRLATADIQVGDVLVR KGELVLVLLEGANFDPEHFPNPGSIELDRPNPTSHLAFGRGQHFCPGSALGRRHAQIGIE ALLKKMPGVDLAVPIDQLVWRTRFQRRIPERLPVLW
- Number of residues
- 396
- Molecular Weight
- 43255.455
- Theoretical pI
- Not Available
- GO Classification
- Functionscarbon monoxide binding / cyclase activity / heme binding / iron ion binding / monooxygenase activity / oxidoreductase activity / oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygenProcessesgrowth / oxidation-reduction process / sterol metabolic processComponentscytoplasm
- General Function
- Catalyzes C-C bond formation between the carbons ortho to the phenolic hydroxyl of cyclo(L-tyr-L-tyr) (cYY) producing mycocyclosin. Can also use cyclo(L-Tyr-L-Phe) (cYF), cyclo(L-Tyr-L-Trp) (cYW) and cyclo(L-Tyr-L-3,4-dihydroxyphenylalanine) (cY-DOPA) as substrate.
- Specific Function
- Carbon monoxide binding
- Pfam Domain Function
- p450 (PF00067)
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0051129|Mycocyclosin synthase (cyp121) ATGACCGCGACCGTTCTGCTCGAGGTCCCGTTCTCTGCACGTGGGGATCGGATTCCTGAC GCCGTCGCAGAATTACGAACCCGCGAGCCTATCCGCAAGGTACGGACCATTACCGGCGCC GAAGCCTGGCTCGTCTCCTCGTATGCACTGTGCACACAGGTGCTCGAGGATCGGCGTTTT TCCATGAAGGAAACCGCCGCTGCCGGCGCCCCCCGCCTGAACGCGCTGACTGTTCCACCC GAAGTGGTCAACAACATGGGAAACATCGCCGACGCGGGACTGCGCAAGGCGGTGATGAAA GCGATCACACCCAAGGCACCCGGGTTGGAGCAATTCCTACGAGACACCGCGAACTCGCTG CTGGACAACCTGATTACCGAGGGCGCACCAGCCGATCTGCGCAATGACTTCGCCGACCCG CTGGCCACTGCCCTGCACTGCAAGGTTCTGGGCATCCCGCAAGAAGACGGCCCGAAGCTG TTCCGTAGCTTGAGTATCGCTTTCATGAGTTCGGCCGACCCGATCCCCGCCGCGAAGATC AACTGGGATCGCGACATCGAATACATGGCCGGAATTCTGGAAAACCCAAACATCACGACC GGCCTCATGGGTGAGCTCAGCCGCCTCCGGAAAGATCCCGCCTACTCGCACGTCTCCGAC GAACTATTCGCGACCATCGGCGTCACTTTCTTCGGTGCCGGCGTCATCTCAACCGGCAGC TTCCTCACCACCGCGCTGATATCGCTGATACAACGCCCGCAACTTCGGAACTTGTTGCAC GAGAAGCCGGAACTGATCCCGGCCGGTGTAGAGGAACTGCTGCGGATCAATCTCTCCTTC GCCGACGGGTTACCGCGCCTGGCCACCGCCGACATCCAGGTCGGCGACGTGCTGGTCCGC AAGGGGGAGCTGGTGCTGGTGCTGCTCGAGGGCGCCAACTTCGATCCCGAGCACTTCCCT AACCCGGGCAGCATCGAACTCGACCGGCCCAACCCCACCTCGCACCTCGCGTTCGGCCGC GGCCAACACTTCTGTCCTGGATCAGCTCTCGGTCGCCGCCACGCACAGATCGGCATCGAA GCGCTGTTGAAAAAGATGCCCGGCGTCGACCTGGCTGTGCCCATCGACCAATTGGTCTGG CGCACCCGATTCCAAAGACGCATCCCCGAACGCCTTCCGGTGCTCTGGTAG
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P9WPP7 UniProtKB Entry Name CP121_MYCTU - General References
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