Clavaminate synthase 1
Details
- Name
- Clavaminate synthase 1
- Synonyms
- 1.14.11.21
- CAS1
- Clavaminic acid synthase 1
- CS1
- Gene Name
- cs1
- Organism
- Streptomyces clavuligerus (strain ATCC 27064 / DSM 738 / JCM 4710 / NBRC 13307 / NCIMB 12785 / NRRL 3585 / VKM Ac-602)
- Amino acid sequence
>lcl|BSEQ0010917|Clavaminate synthase 1 MTSVDCTAYGPELRALAARLPRTPRADLYAFLDAAHTAAASLPGALATALDTFNAEGSED GHLLLRGLPVEADADLPTTPSSTPAPEDRSLLTMEAMLGLVGRRLGLHTGYRELRSGTVY HDVYPSPGAHHLSSETSETLLEFHTEMAYHRLQPNYVMLACSRADHERTAATLVASVRKA LPLLDERTRARLLDRRMPCCVDVAFRGGVDDPGAIAQVKPLYGDADDPFLGYDRELLAPE DPADKEAVAALSKALDEVTEAVYLEPGDLLIVDNFRTTHARTPFSPRWDGKDRWLHRVYI RTDRNGQLSGGERAGDVVAFTPRG
- Number of residues
- 324
- Molecular Weight
- 35369.325
- Theoretical pI
- 5.24
- GO Classification
- Functionsclavaminate synthase activity / iron ion bindingProcessesantibiotic biosynthetic process / clavulanic acid biosynthetic process
- General Function
- Iron ion binding
- Specific Function
- Not Available
- Pfam Domain Function
- TauD (PF02668)
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0002609|975 bp ATGACCTCAGTGGACTGCACCGCGTACGGCCCCGAGCTGCGCGCGCTCGCCGCCCGGCTG CCCCGGACCCCCCGGGCCGACCTGTACGCCTTCCTGGACGCCGCGCACACAGCCGCCGCC TCGCTCCCCGGCGCCCTCGCCACCGCGCTGGACACCTTCAACGCCGAGGGCAGCGAGGAC GGCCATCTGCTGCTGCGCGGCCTCCCGGTGGAGGCCGACGCCGACCTCCCCACCACCCCG AGCAGCACCCCGGCGCCCGAGGACCGCTCCCTGCTGACCATGGAGGCCATGCTCGGACTG GTGGGCCGCCGGCTCGGTCTGCACACGGGGTACCGGGAGCTGCGCTCGGGCACGGTCTAC CACGACGTGTACCCGTCGCCCGGCGCGCACCACCTGTCCTCGGAGACCTCCGAGACGCTG CTGGAGTTCCACACGGAGATGGCCTACCACCGGCTCCAGCCGAACTACGTCATGCTGGCC TGCTCCCGGGCCGACCACGAGCGCACGGCGGCCACACTCGTCGCCTCGGTCCGCAAGGCG CTGCCCCTGCTGGACGAGAGGACCCGGGCCCGGCTCCTCGACCGGAGGATGCCCTGCTGC GTGGATGTGGCCTTCCGCGGCGGGGTGGACGACCCGGGCGCCATCGCCCAGGTCAAACCG CTCTACGGGGACGCGGACGATCCCTTCCTCGGGTACGACCGCGAGCTGCTGGCGCCGGAG GACCCCGCGGACAAGGAGGCCGTCGCCGCCCTGTCCAAGGCGCTCGACGAGGTCACGGAG GCGGTGTATCTGGAGCCCGGCGATCTGCTGATCGTCGACAACTTCCGCACCACGCACGCG CGGACGCCGTTCTCGCCCCGCTGGGACGGGAAGGACCGCTGGCTGCACCGCGTCTACATC CGCACCGACCGCAATGGACAGCTCTCCGGCGGCGAGCGCGCGGGCGACGTCGTCGCCTTC ACACCGCGCGGCTGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q05581 UniProtKB Entry Name CAS1_STRC2 GenBank Protein ID 153220 GenBank Gene ID L06213 - General References
- Marsh EN, Chang MD, Townsend CA: Two isozymes of clavaminate synthase central to clavulanic acid formation: cloning and sequencing of both genes from Streptomyces clavuligerus. Biochemistry. 1992 Dec 22;31(50):12648-57. [Article]
- Busby RW, Chang MD, Busby RC, Wimp J, Townsend CA: Expression and purification of two isozymes of clavaminate synthase and initial characterization of the iron binding site. General error analysis in polymerase chain reaction amplification. J Biol Chem. 1995 Mar 3;270(9):4262-9. [Article]
- Zhang Z, Ren J, Stammers DK, Baldwin JE, Harlos K, Schofield CJ: Structural origins of the selectivity of the trifunctional oxygenase clavaminic acid synthase. Nat Struct Biol. 2000 Feb;7(2):127-33. [Article]
- Zhang Z, Ren Js, Harlos K, McKinnon CH, Clifton IJ, Schofield CJ: Crystal structure of a clavaminate synthase-Fe(II)-2-oxoglutarate-substrate-NO complex: evidence for metal centered rearrangements. FEBS Lett. 2002 Apr 24;517(1-3):7-12. [Article]