Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase
Details
- Name
- Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase
- Synonyms
- 2.4.2.21
- N(1)-alpha-phosphoribosyltransferase
- NN:DBI PRT
- Gene Name
- cobT
- Organism
- Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
- Amino acid sequence
>lcl|BSEQ0002447|Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase MQTLHALLRDIPAPDAEAMARAQQHIDGLLKPPGSLGRLETLAVQLAGMPGLNGTPQVGE KAVLVMCADHGVWDEGVAVSPKIVTAIQAANMTRGTTGVCVLAAQAGAKVHVIDVGIDAE PIPGVVNMRVARGCGNIAVGPAMSRLQAEALLLEVSRYTCDLAQRGVTLFGVGELGMANT TPAAAMVSVFTGSDAKEVVGIGANLPPSRIDNKVDVVRRAIAINQPNPRDGIDVLSKVGG FDLVGMTGVMLGAARCGLPVLLDGFLSYSAALAACQIAPAVRPYLIPSHFSAEKGARIAL AHLSMEPYLHMAMRLGEGSGAALAMPIVEAACAMFHNMGELAASNIVLPEGNANAT
- Number of residues
- 356
- Molecular Weight
- 36612.305
- Theoretical pI
- 6.3
- GO Classification
- Functionscobalamin-transporting ATPase activity / nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activityProcessescobalamin biosynthetic process / nucleoside biosynthetic process
- General Function
- Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
- Specific Function
- Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).
- Pfam Domain Function
- DBI_PRT (PF02277)
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0016358|Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (cobT) ATGCAGACACTACACGCTTTACTCCGTGACATTCCTGCGCCGGACGCCGAGGCGATGGCG CGTGCGCAGCAACATATTGACGGCCTGCTCAAACCGCCGGGCAGCCTGGGCAGACTGGAA ACCTTAGCCGTTCAGCTCGCGGGTATGCCGGGTCTTAACGGTACGCCGCAGGTAGGTGAA AAGGCGGTGCTGGTGATGTGCGCCGACCATGGCGTCTGGGATGAAGGCGTAGCGGTTTCG CCCAAAATCGTGACGGCGATTCAGGCGGCGAATATGACGCGGGGAACAACCGGCGTATGC GTGCTTGCCGCTCAGGCCGGTGCGAAGGTGCATGTCATTGATGTCGGTATTGATGCCGAA CCTATTCCTGGCGTAGTTAATATGCGCGTCGCGCGCGGCTGCGGAAATATTGCCGTTGGC CCGGCGATGAGTCGCTTGCAGGCTGAGGCGCTTTTGCTGGAGGTTTCCCGCTACACCTGC GACCTGGCGCAACGCGGCGTGACCTTATTTGGCGTAGGGGAGCTGGGAATGGCGAACACT ACGCCAGCCGCCGCGATGGTCAGCGTTTTTACAGGAAGTGATGCAAAAGAGGTGGTGGGG ATTGGCGCGAATCTTCCGCCTTCCCGCATCGATAATAAAGTGGACGTCGTGCGGCGGGCG ATTGCGATTAATCAGCCCAATCCGCGCGACGGCATTGATGTGTTGTCGAAGGTGGGTGGT TTTGATCTGGTCGGGATGACCGGCGTGATGCTTGGCGCGGCAAGGTGTGGCTTACCCGTA TTGCTGGATGGCTTTCTTTCCTACTCGGCAGCGCTGGCGGCCTGTCAGATTGCGCCTGCG GTGAGACCTTATCTGATCCCGTCGCACTTTTCGGCGGAAAAGGGCGCCCGCATCGCGCTC GCGCATTTGTCTATGGAACCCTATTTGCATATGGCGATGCGGTTAGGTGAAGGAAGCGGC GCGGCGCTGGCGATGCCGATCGTGGAAGCCGCGTGCGCCATGTTCCACAACATGGGGGAG TTGGCGGCCAGTAATATTGTCCTGCCGGAGGGGAACGCAAACGCAACATAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q05603 UniProtKB Entry Name COBT_SALTY GenBank Protein ID 535767 GenBank Gene ID L35477 - General References
- Chen P, Ailion M, Weyand N, Roth J: The end of the cob operon: evidence that the last gene (cobT) catalyzes synthesis of the lower ligand of vitamin B12, dimethylbenzimidazole. J Bacteriol. 1995 Mar;177(6):1461-9. [Article]
- McClelland M, Sanderson KE, Spieth J, Clifton SW, Latreille P, Courtney L, Porwollik S, Ali J, Dante M, Du F, Hou S, Layman D, Leonard S, Nguyen C, Scott K, Holmes A, Grewal N, Mulvaney E, Ryan E, Sun H, Florea L, Miller W, Stoneking T, Nhan M, Waterston R, Wilson RK: Complete genome sequence of Salmonella enterica serovar Typhimurium LT2. Nature. 2001 Oct 25;413(6858):852-6. [Article]
- Roth JR, Lawrence JG, Rubenfield M, Kieffer-Higgins S, Church GM: Characterization of the cobalamin (vitamin B12) biosynthetic genes of Salmonella typhimurium. J Bacteriol. 1993 Jun;175(11):3303-16. [Article]
- Cheong CG, Escalante-Semerena JC, Rayment I: The three-dimensional structures of nicotinate mononucleotide:5,6- dimethylbenzimidazole phosphoribosyltransferase (CobT) from Salmonella typhimurium complexed with 5,6-dimethybenzimidazole and its reaction products determined to 1.9 A resolution. Biochemistry. 1999 Dec 7;38(49):16125-35. [Article]
Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB01688 P-Cresol experimental unknown Details DB01726 2-Aminophenol experimental unknown Details DB02030 Alpha-Ribazole-5'-Phosphate experimental unknown Details DB02163 2,5-Xylidine experimental unknown Details DB02382 Namn experimental unknown Details DB00173 Adenine approved, nutraceutical unknown Details DB02591 5,6-Dimethylbenzimidazole experimental unknown Details DB02770 7-alpha-D-Ribofuranosyl-2-aminopurine-5'-phosphate experimental unknown Details DB02819 Mono-[3,4-Dihydroxy-5-(5-Methyl-Benzoimidazol-1-Yl)-Tetrahydor-Furan-2-Ylmethyl] Ester experimental unknown Details DB02905 N7-(5'-Phospho-alpha-ribosyl)-2-hydroxypurine experimental unknown Details DB02962 Benzimidazole experimental, investigational unknown Details DB03018 3,4-dimethylaniline experimental unknown Details DB03079 Alpha-Ribazole-5'-Phosphate Derivative experimental unknown Details DB03177 5-methylbenzimidazole experimental unknown Details DB03180 4,5-Dimethyl-1,2-phenylenediamine experimental unknown Details DB03200 7-Alpha-D-Ribofuranosyl-Purine-5'-Phosphate experimental unknown Details DB03366 Imidazole experimental, investigational unknown Details DB03887 Alpha-Adenosine Monophosphate experimental unknown Details DB04052 3,4-Xylenol experimental unknown Details DB04120 4-Methyl-1,2-Benzenediol experimental unknown Details DB04130 5-Methoxybenzimidazole experimental unknown Details DB04176 Phosporic Acid Mono-[3,4-Dihydroxy-5-(5-Methoxy-Benzoimidazol-1-Yl)-Tetrahydro-Furan-2-Ylmethyl] Ester experimental unknown Details DB04532 Indole experimental unknown Details DB04533 2-Amino-4-methylphenol experimental unknown Details