cAMP-specific 3',5'-cyclic phosphodiesterase 4B
Details
- Name
- cAMP-specific 3',5'-cyclic phosphodiesterase 4B
- Synonyms
- 3.1.4.53
- DPDE4
- PDE32
- Gene Name
- PDE4B
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0000972|cAMP-specific 3',5'-cyclic phosphodiesterase 4B MKKSRSVMTVMADDNVKDYFECSLSKSYSSSSNTLGIDLWRGRRCCSGNLQLPPLSQRQS ERARTPEGDGISRPTTLPLTTLPSIAITTVSQECFDVENGPSPGRSPLDPQASSSAGLVL HATFPGHSQRRESFLYRSDSDYDLSPKAMSRNSSLPSEQHGDDLIVTPFAQVLASLRSVR NNFTILTNLHGTSNKRSPAASQPPVSRVNPQEESYQKLAMETLEELDWCLDQLETIQTYR SVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKK KQQLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSH NRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHV LLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHL AVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTS SGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEI SPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSP SPPLDEQNRDCQGLMEKFQFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVIDPENRDSLG ETDIDIATEDKSPVDT
- Number of residues
- 736
- Molecular Weight
- 83342.695
- Theoretical pI
- 4.89
- GO Classification
- Functions3',5'-cyclic-AMP phosphodiesterase activity / cAMP binding / ion channel binding / metal ion bindingProcessescAMP catabolic process / cellular response to drug / cellular response to epinephrine stimulus / cellular response to lipopolysaccharide / leukocyte migration / negative regulation of relaxation of cardiac muscle / neutrophil chemotaxis / neutrophil homeostasis / positive regulation of interferon-gamma production / positive regulation of interleukin-2 production / regulation of cardiac muscle cell contraction / regulation of high voltage-gated calcium channel activity / T cell receptor signaling pathwayComponentscell periphery / centrosome / cytosol / dendritic spine / excitatory synapse / gamma-tubulin complex / membrane / postsynaptic density / synaptic vesicle / Z disc
- General Function
- Metal ion binding
- Specific Function
- Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents.
- Pfam Domain Function
- PDEase_I (PF00233)
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasmic
- Gene sequence
>lcl|BSEQ0016107|cAMP-specific 3',5'-cyclic phosphodiesterase 4B (PDE4B) ATGAAGGAGCACGGGGGCACCTTCAGTAGCACCGGAATCAGCGGTGGTAGCGGTGACTCT GCTATGGACAGCCTGCAGCCGCTCCAGCCTAACTACATGCCTGTGTGTTTGTTTGCAGAA GAATCTTATCAAAAATTAGCAATGGAAACGCTGGAGGAATTAGACTGGTGTTTAGACCAG CTAGAGACCATACAGACCTACCGGTCTGTCAGTGAGATGGCTTCTAACAAGTTCAAAAGA ATGCTGAACCGGGAGCTGACACACCTCTCAGAGATGAGCCGATCAGGGAACCAGGTGTCT GAATACATTTCAAATACTTTCTTAGACAAGCAGAATGATGTGGAGATCCCATCTCCTACC CAGAAAGACAGGGAGAAAAAGAAAAAGCAGCAGCTCATGACCCAGATAAGTGGAGTGAAG AAATTAATGCATAGTTCAAGCCTAAACAATACAAGCATCTCACGCTTTGGAGTCAACACT GAAAATGAAGATCACCTGGCCAAGGAGCTGGAAGACCTGAACAAATGGGGTCTTAACATC TTTAATGTGGCTGGATATTCTCACAATAGACCCCTAACATGCATCATGTATGCTATATTC CAGGAAAGAGACCTCCTAAAGACATTCAGAATCTCATCTGACACATTTATAACCTACATG ATGACTTTAGAAGACCATTACCATTCTGACGTGGCATATCACAACAGCCTGCACGCTGCT GATGTAGCCCAGTCGACCCATGTTCTCCTTTCTACACCAGCATTAGACGCTGTCTTCACA GATTTGGAGATCCTGGCTGCCATTTTTGCAGCTGCCATCCATGACGTTGATCATCCTGGA GTCTCCAATCAGTTTCTCATCAACACAAATTCAGAACTTGCTTTGATGTATAATGATGAA TCTGTGTTGGAAAATCATCACCTTGCTGTGGGTTTCAAACTGCTGCAAGAAGAACACTGT GACATCTTCATGAATCTCACCAAGAAGCAGCGTCAGACACTCAGGAAGATGGTTATTGAC ATGGTGTTAGCAACTGATATGTCTAAACATATGAGCCTGCTGGCAGACCTGAAGACAATG GTAGAAACGAAGAAAGTTACAAGTTCAGGCGTTCTTCTCCTAGACAACTATACCGATCGC ATTCAGGTCCTTCGCAACATGGTACACTGTGCAGACCTGAGCAACCCCACCAAGTCCTTG GAATTGTATCGGCAATGGACAGACCGCATCATGGAGGAATTTTTCCAGCAGGGAGACAAA GAGCGGGAGAGGGGAATGGAAATTAGCCCAATGTGTGATAAACACACAGCTTCTGTGGAA AAATCCCAGGTTGGTTTCATCGACTACATTGTCCATCCATTGTGGGAGACATGGGCAGAT TTGGTACAGCCTGATGCTCAGGACATTCTCGATACCTTAGAAGATAACAGGAACTGGTAT CAGAGCATGATACCTCAAAGTCCCTCACCACCACTGGACGAGCAGAACAGGGACTGCCAG GGTCTGATGGAGAAGTTTCAGTTTGAACTGACTCTCGATGAGGAAGATTCTGAAGGACCT GAGAAGGAGGGAGAGGGACACAGCTATTTCAGCAGCACAAAGACGCTTTGTGTGATTGAT CCAGAAAACAGAGATTCCCTGGGAGAGACTGACATAGACATTGCAACAGAAGACAAGTCC CCCGTGGATACATAA
- Chromosome Location
- 1
- Locus
- 1p31
- External Identifiers
Resource Link UniProtKB ID Q07343 UniProtKB Entry Name PDE4B_HUMAN GenBank Protein ID 347122 GenBank Gene ID L20966 GenAtlas ID PDE4B HGNC ID HGNC:8781 - General References
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Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB00651 Dyphylline approved yes inhibitor Details DB00824 Enprofylline approved, experimental yes inhibitor Details DB01113 Papaverine approved, investigational yes inhibitor Details DB00201 Caffeine approved unknown inhibitor Details DB00277 Theophylline approved yes inhibitor Details DB01647 Daxalipram experimental unknown Details DB00131 Adenosine phosphate approved, investigational, nutraceutical, withdrawn unknown product of Details DB01954 Rolipram investigational unknown Details DB01959 3,5-Dimethyl-1-(3-Nitrophenyl)-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester experimental unknown Details DB02660 Filaminast experimental unknown inhibitor Details DB03349 8-Bromo-Adenosine-5'-Monophosphate experimental unknown Details DB03606 (S)-Rolipram experimental unknown inhibitor Details DB03807 1-(2-Chlorophenyl)-3,5-Dimethyl-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester experimental unknown Details DB03849 Cilomilast investigational yes inhibitor Details DB04149 (R)-Rolipram experimental unknown inhibitor Details DB04530 S,S-(2-Hydroxyethyl)Thiocysteine experimental unknown Details DB05219 Crisaborole approved, investigational unknown inhibitor Details DB01791 Piclamilast experimental unknown Details DB01088 Iloprost approved, investigational unknown inducer Details DB06909 1-ethyl-N-(phenylmethyl)-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridine-5-carboxamide experimental unknown Details DB08299 4-[8-(3-nitrophenyl)-1,7-naphthyridin-6-yl]benzoic acid experimental unknown Details DB05266 Ibudilast investigational yes inhibitor Details DB01412 Theobromine investigational unknown inhibitor Details DB00201 Caffeine approved unknown inhibitor Details DB09283 Trapidil experimental yes inhibitor Details DB01427 Amrinone approved yes inhibitor Details DB01954 Rolipram investigational yes inhibitor Details DB01656 Roflumilast approved yes inhibitor Details