ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2
Details
- Name
- ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2
- Synonyms
- 3.2.2.6
- ADP-ribosyl cyclase 2
- Bone marrow stromal antigen 1
- BST-1
- cADPr hydrolase 2
- Cyclic ADP-ribose hydrolase 2
- Gene Name
- BST1
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0002471|ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 MAAQGCAASRLLQLLLQLLLLLLLLAAGGARARWRGEGTSAHLRDIFLGRCAEYRALLSP EQRNKNCTAIWEAFKVALDKDPCSVLPSDYDLFINLSRHSIPRDKSLFWENSHLLVNSFA DNTRRFMPLSDVLYGRVADFLSWCRQKNDSGLDYQSCPTSEDCENNPVDSFWKRASIQYS KDSSGVIHVMLNGSEPTGAYPIKGFFADYEIPNLQKEKITRIEIWVMHEIGGPNVESCGE GSMKVLEKRLKDMGFQYSCINDYRPVKLLQCVDHSTHPDCALKSAAAATQRKAPSLYTEQ RAGLIIPLFLVLASRTQL
- Number of residues
- 318
- Molecular Weight
- 35723.545
- Theoretical pI
- 7.86
- GO Classification
- FunctionsNAD(P)+ nucleosidase activity / NAD+ nucleosidase activity / phosphorus-oxygen lyase activity / transferase activityProcesseshumoral immune response / multicellular organismal development / positive regulation of B cell proliferationComponentsanchored component of membrane / extracellular exosome / extrinsic component of membrane / plasma membrane
- General Function
- Transferase activity
- Specific Function
- Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger that elicits calcium release from intracellular stores. May be involved in pre-B-cell growth.
- Pfam Domain Function
- Rib_hydrolayse (PF02267)
- Transmembrane Regions
- Not Available
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0010864|ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 (BST1) ATGGCGGCCCAGGGGTGCGCGGCATCGCGGCTGCTCCAGCTGCTGCTGCAGCTTCTGCTT CTACTGTTGCTGCTGGCGGCGGGCGGGGCGCGCGCGCGGTGGCGCGGGGAGGGCACCAGC GCACACTTGCGGGACATCTTCCTGGGCCGCTGCGCCGAGTACCGCGCACTGCTGAGTCCC GAGCAGCGGAACAAGAACTGCACAGCCATCTGGGAAGCCTTTAAAGTGGCGCTGGACAAG GATCCCTGCTCCGTGCTGCCCTCAGACTATGACCTTTTTATTAACTTGTCCAGGCACTCT ATTCCCAGAGATAAGTCCCTGTTCTGGGAAAATAGCCACCTCCTTGTTAACAGCTTTGCA GACAACACCCGTCGTTTTATGCCCCTGAGCGATGTTCTGTATGGCAGGGTTGCAGATTTC TTGAGCTGGTGTCGACAGAAAAATGACTCTGGACTCGATTACCAATCCTGCCCTACATCA GAAGACTGTGAAAATAATCCTGTGGATTCCTTTTGGAAAAGGGCATCCATCCAGTATTCC AAGGATAGTTCTGGGGTGATCCACGTCATGCTGAATGGTTCAGAGCCAACAGGAGCCTAT CCCATCAAAGGTTTTTTTGCAGATTATGAAATTCCAAACCTCCAGAAGGAAAAAATTACA CGAATCGAGATCTGGGTTATGCATGAAATTGGGGGACCCAATGTGGAATCCTGCGGGGAA GGCAGCATGAAAGTCCTGGAAAAGAGGCTGAAGGACATGGGGTTCCAGTACAGCTGTATT AATGATTACCGACCAGTGAAGCTCTTACAGTGCGTGGACCACAGCACCCATCCTGACTGT GCCTTAAAGTCGGCAGCAGCCGCTACTCAAAGAAAAGCCCCAAGTCTTTATACAGAACAA AGGGCGGGTCTTATCATTCCCCTCTTTCTGGTGCTGGCTTCCAGGACTCAACTGTAA
- Chromosome Location
- 4
- Locus
- 4p15
- External Identifiers
Resource Link UniProtKB ID Q10588 UniProtKB Entry Name BST1_HUMAN GenBank Protein ID 999429 GenBank Gene ID D21878 GenAtlas ID BST1 HGNC ID HGNC:1118 - General References
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Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB02930 Adenosine 5'-[gamma-thio]triphosphate experimental unknown Details DB02483 Etheno-NAD experimental unknown Details DB02701 Nicotinamide approved, investigational yes product of Details DB03227 Nicotinamide Mononucleotide experimental unknown Details DB03732 Etheno-Nadp experimental unknown Details