C-terminal-binding protein 1
Details
- Name
- C-terminal-binding protein 1
- Synonyms
- 1.1.1.-
- CTBP
- CtBP1
- Gene Name
- CTBP1
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0005147|C-terminal-binding protein 1 MGSSHLLNKGLPLGVRPPIMNGPLHPRPLVALLDGRDCTVEMPILKDVATVAFCDAQSTQ EIHEKVLNEAVGALMYHTITLTREDLEKFKALRIIVRIGSGFDNIDIKSAGDLGIAVCNV PAASVEETADSTLCHILNLYRRATWLHQALREGTRVQSVEQIREVASGAARIRGETLGII GLGRVGQAVALRAKAFGFNVLFYDPYLSDGVERALGLQRVSTLQDLLFHSDCVTLHCGLN EHNHHLINDFTVKQMRQGAFLVNTARGGLVDEKALAQALKEGRIRGAALDVHESEPFSFS QGPLKDAPNLICTPHAAWYSEQASIEMREEAAREIRRAITGRIPDSLKNCVNKDHLTAAT HWASMDPAVVHPELNGAAYRYPPGVVGVAPTGIPAAVEGIVPSAMSLSHGLPPVAHPPHA PSPGQTVKPEADRDHASDQL
- Number of residues
- 440
- Molecular Weight
- 47534.865
- Theoretical pI
- 6.76
- GO Classification
- FunctionsNAD binding / NADH binding / oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor / protein C-terminus binding / protein domain specific binding / protein homodimerization activity / repressing transcription factor binding / RNA polymerase II transcription corepressor activity / transcription factor activity, sequence-specific DNA binding / transcription factor bindingProcessesnegative regulation of cell proliferation / negative regulation of histone acetylation / negative regulation of histone H4 acetylation / negative regulation of transcription from RNA polymerase II promoter / negative regulation of transcription from RNA polymerase II promoter by histone modification / negative regulation of transcription, DNA-templated / positive regulation of histone deacetylation / protein phosphorylation / regulation of cell cycle / transcription, DNA-templated / viral genome replication / white fat cell differentiationComponentscytoplasm / nucleoplasm / nucleus / transcription factor complex / transcriptional repressor complex
- General Function
- Transcription factor binding
- Specific Function
- Corepressor targeting diverse transcription regulators such as GLIS2 or BCL6. Has dehydrogenase activity. Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex. Functions in brown adipose tissue (BAT) differentiation.
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0019311|C-terminal-binding protein 1 (CTBP1) ATGTCAGGCGTCCGACCTCCGATCATGAACGGGCCCCTGCACCCGCGGCCCCTGGTGGCA TTGCTGGATGGCCGGGACTGCACAGTGGAGATGCCCATCCTGAAGGACGTGGCCACTGTG GCCTTCTGCGACGCGCAGTCCACGCAGGAGATCCATGAGAAGGTCCTGAACGAGGCTGTG GGGGCCCTGATGTACCACACCATCACTCTCACCAGGGAGGACCTGGAGAAGTTCAAAGCC CTCCGCATCATCGTCCGGATTGGCAGTGGTTTTGACAACATCGACATCAAGTCGGCCGGG GATTTAGGCATTGCCGTCTGCAACGTGCCCGCGGCGTCTGTGGAGGAGACGGCCGACTCG ACGCTGTGCCACATCCTGAACCTGTACCGGCGGGCCACCTGGCTGCACCAGGCGCTGCGG GAGGGCACACGAGTCCAGAGCGTCGAGCAGATCCGCGAGGTGGCGTCCGGCGCTGCCAGG ATCCGCGGGGAGACCTTGGGCATCATCGGACTTGGTCGCGTGGGGCAGGCAGTGGCGCTG CGGGCCAAGGCCTTCGGCTTCAACGTGCTCTTCTACGACCCTTACTTGTCGGATGGCGTG GAGCGGGCGCTGGGGCTGCAGCGTGTCAGCACCCTGCAGGACCTGCTCTTCCACAGCGAC TGCGTGACCCTGCACTGCGGCCTCAACGAGCACAACCACCACCTCATCAACGACTTCACC GTCAAGCAGATGAGACAAGGGGCCTTCCTGGTGAACACAGCCCGGGGTGGCCTGGTGGAT GAGAAGGCGCTGGCCCAGGCCCTGAAGGAGGGCCGGATCCGCGGCGCGGCCCTGGATGTG CACGAGTCGGAACCCTTCAGCTTTAGCCAGGGCCCTCTGAAGGATGCACCCAACCTCATC TGCACCCCCCATGCTGCATGGTACAGCGAGCAGGCATCCATCGAGATGCGAGAGGAGGCG GCACGGGAGATCCGCAGAGCCATCACAGGCCGGATCCCAGACAGCCTGAAGAACTGTGTC AACAAGGACCATCTGACAGCCGCCACCCACTGGGCCAGCATGGACCCCGCCGTCGTGCAC CCTGAGCTCAATGGGGCTGCCTATAGGTACCCTCCGGGCGTGGTGGGCGTGGCCCCCACT GGCATCCCAGCTGCTGTGGAAGGTATCGTCCCCAGCGCCATGTCCCTGTCCCACGGCCTG CCCCCTGTGGCCCACCCGCCCCACGCCCCTTCTCCTGGCCAAACCGTCAAGCCCGAGGCG GATAGAGACCACGCCAGTGACCAGTTGTAG
- Chromosome Location
- 4
- Locus
- 4p16
- External Identifiers
Resource Link UniProtKB ID Q13363 UniProtKB Entry Name CTBP1_HUMAN GenBank Gene ID U37408 GenAtlas ID CTBP1 HGNC ID HGNC:2494 - General References
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