Non-receptor tyrosine-protein kinase TNK1
Details
- Name
- Non-receptor tyrosine-protein kinase TNK1
- Synonyms
- 2.7.10.2
- CD38 negative kinase 1
- Gene Name
- TNK1
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0051678|Non-receptor tyrosine-protein kinase TNK1 MLPEAGSLWLLKLLRDIQLAQFYWPILEELNVTRPEHFDFVKPEDLDGIGMGRPAQRRLS EALKRLRSGPKSKNWVYKILGGFAPEHKEPTLPSDSPRHLPEPEGGLKCLIPEGAVCRGE LLGSGCFGVVHRGLWTLPSGKSVPVAVKSLRVGPEGPMGTELGDFLREVSVMMNLEHPHV LRLHGLVLGQPLQMVMELAPLGSLHARLTAPAPTPPLLVALLCLFLRQLAGAMAYLGARG LVHRDLATRNLLLASPRTIKVADFGLVRPLGGARGRYVMGGPRPIPYAWCAPESLRHGAF SSASDVWMFGVTLWEMFSGGEEPWAGVPPYLILQRLEDRARLPRPPLCSRALYSLALRCW APHPADRPSFSHLEGLLQEAGPSEACCVRDVTEPGALRMETGDPITVIEGSSSFHSPDST IWKGQNGRTFKVGSFPASAVTLADAGGLPATRPVHRGTPARGDQHPGSIDGDRKKANLWD APPARGQRRNMPLERMKGISRSLESVLSLGPRPTGGGSSPPEIRQARAVPQGPPGLPPRP PLSSSSPQPSQPSRERLPWPKRKPPHNHPMGMPGARKAAALSGGLLSDPELQRKIMEVEL SVHGVTHQECQTALGATGGDVVSAIRNLKVDQLFHLSSRSRADCWRILEHYQWDLSAASR YVLARP
- Number of residues
- 666
- Molecular Weight
- 72466.995
- Theoretical pI
- Not Available
- GO Classification
- FunctionsATP binding / non-membrane spanning protein tyrosine kinase activity / protein tyrosine kinase activity / receptor binding / signal transducer activityProcessescell differentiation / cell migration / innate immune response / negative regulation of cell growth / negative regulation of Ras protein signal transduction / peptidyl-tyrosine autophosphorylation / protein autophosphorylation / protein phosphorylation / regulation of cell proliferation / transmembrane receptor protein tyrosine kinase signaling pathwayComponentscytoplasm / cytosol / extrinsic component of cytoplasmic side of plasma membrane / membrane
- General Function
- Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway. May function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues and in cells of the lymphohematopoietic system. Could specifically be involved in phospholipid signal transduction.
- Specific Function
- Atp binding
- Pfam Domain Function
- PK_Tyr_Ser-Thr (PF07714)
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0051679|Non-receptor tyrosine-protein kinase TNK1 (TNK1) ATGCTTCCTGAGGCTGGCTCCCTGTGGCTACTGAAGCTGCTCCGGGACATCCAGTTGGCC CAGTTTTACTGGCCCATCCTTGAGGAGCTTAATGTCACTCGGCCAGAGCACTTCGACTTT GTAAAGCCTGAGGACCTGGACGGCATTGGCATGGGCCGGCCTGCCCAGCGCAGACTGTCC GAAGCTCTGAAAAGGCTACGTTCTGGGCCTAAGTCTAAGAACTGGGTCTACAAGATCCTT GGAGGTTTTGCCCCTGAGCACAAGGAGCCCACCCTGCCCTCGGACAGCCCACGGCACCTC CCTGAGCCAGAGGGGGGCCTCAAGTGTCTGATCCCAGAGGGTGCTGTTTGCAGAGGGGAG CTGCTGGGTTCAGGCTGCTTCGGTGTGGTGCACCGAGGGCTGTGGACGCTGCCCAGTGGC AAGAGTGTCCCAGTGGCTGTCAAGTCCCTCCGGGTAGGTCCCGAAGGCCCGATGGGCACA GAACTGGGGGACTTCCTGCGAGAGGTATCGGTCATGATGAACTTGGAGCACCCACACGTG CTGCGTCTGCACGGCCTTGTACTGGGCCAGCCTCTGCAGATGGTGATGGAGCTGGCGCCA CTGGGCTCCCTGCACGCGCGCCTAACGGCCCCGGCCCCGACACCCCCGCTGCTCGTGGCC CTGCTCTGCCTCTTCCTGCGGCAGCTGGCGGGAGCCATGGCGTACCTGGGGGCCCGCGGG CTGGTGCACCGAGACCTCGCTACGCGCAACCTACTGCTGGCGTCGCCGCGCACCATCAAG GTGGCTGACTTCGGGCTGGTGCGGCCTCTGGGCGGTGCCCGGGGCCGCTACGTCATGGGC GGGCCCCGCCCTATCCCCTACGCCTGGTGTGCCCCAGAGAGCCTGCGCCACGGAGCCTTC TCGTCTGCCTCGGACGTGTGGATGTTTGGGGTGACGCTGTGGGAGATGTTCTCCGGGGGC GAGGAACCCTGGGCCGGGGTCCCACCGTACCTCATCCTGCAGCGGCTGGAGGACAGAGCC CGGCTGCCTAGGCCTCCCCTCTGCTCCAGGGCCCTCTACTCCCTCGCCTTGCGCTGCTGG GCCCCCCACCCTGCCGACCGGCCTAGCTTTTCCCACCTGGAGGGGCTGCTGCAAGAGGCC GGGCCTTCGGAAGCATGTTGTGTGAGGGATGTCACAGAACCAGGCGCCCTGAGGATGGAG ACTGGTGACCCCATCACAGTCATCGAGGGCAGCTCCTCTTTCCACAGCCCCGACTCCACA ATCTGGAAGGGCCAGAATGGTCGCACCTTCAAAGTGGGCAGCTTCCCAGCCTCGGCAGTG ACGCTGGCAGATGCGGGGGGCTTGCCAGCCACCCGTCCAGTCCACAGAGGCACCCCTGCC CGGGGAGATCAACACCCAGGAAGCATAGATGGAGACAGAAAGAAGGCAAATCTTTGGGAT GCGCCCCCAGCACGGGGCCAGAGGAGGAACATGCCCCTGGAGAGGATGAAAGGCATTTCC AGGAGTCTGGAGTCAGTTCTGTCCCTCGGTCCTCGTCCCACAGGGGGTGGTTCAAGCCCC CCTGAAATTCGACAAGCCAGAGCTGTGCCCCAGGGACCTCCAGGCCTGCCTCCACGCCCA CCTTTATCCTCTAGCTCTCCTCAGCCCAGCCAGCCCTCTAGGGAGAGGCTTCCCTGGCCC AAAAGAAAACCCCCACACAATCACCCCATGGGAATGCCTGGAGCCCGTAAAGCCGCTGCC CTCTCTGGAGGCCTCTTGTCCGATCCTGAGTTGCAGAGGAAGATTATGGAGGTGGAGCTG AGTGTGCATGGGGTCACCCACCAGGAGTGCCAGACAGCACTAGGAGCCACTGGGGGAGAT GTGGTTTCTGCCATCCGGAACCTCAAGGTAGATCAGCTCTTCCACCTGAGTAGCCGGTCC AGAGCTGACTGCTGGCGCATCCTGGAGCATTACCAGTGGGACCTCTCAGCTGCCAGCCGC TATGTCCTGGCCAGGCCCTGA
- Chromosome Location
- 17
- Locus
- 17p13.1
- External Identifiers
Resource Link UniProtKB ID Q13470 UniProtKB Entry Name TNK1_HUMAN HGNC ID HGNC:11940 - General References
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