L-lactate dehydrogenase
Details
- Name
- L-lactate dehydrogenase
- Synonyms
- 1.1.1.27
- LDH-P
- Gene Name
- Not Available
- Organism
- Plasmodium falciparum (isolate CDC / Honduras)
- Amino acid sequence
>lcl|BSEQ0011017|L-lactate dehydrogenase MAPKAKIVLVGSGMIGGVMATLIVQKNLGDVVLFDIVKNMPHGKALDTSHTNVMAYSNCK VSGSNTYDDLAGADVVIVTAGFTKAPGKSDKEWNRDDLLPLNNKIMIEIGGHIKKNCPNA FIIVVTNPVDVMVQLLHQHSGVPKNKIIGLGGVLDTSRLKYYISQKLNVCPRDVNAHIVG AHGNKMVLLKRYITVGGIPLQEFINNKLISDAELEAIFDRTVNTALEIVNLHASPYVAPA AAIIEMAESYLKDLKKVLICSTLLEGQYGHSDIFGGTPVVLGANGVEQVIELQLNSEEKA KFDEAIAETKRMKALA
- Number of residues
- 316
- Molecular Weight
- 34107.505
- Theoretical pI
- 7.63
- GO Classification
- FunctionsL-lactate dehydrogenase activityProcessescarbohydrate metabolic process / carboxylic acid metabolic process
- General Function
- L-lactate dehydrogenase activity
- Specific Function
- Not Available
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0002873|951 bp ATGGCACCAAAAGCAAAAATCGTTTTAGTTGGCTCAGGTATGATTGGAGGAGTAATGGCT ACCTTAATTGTTCAGAAAAATTTAGGAGATGTAGTTTTGTTCGATATTGTAAAGAACATG CCACATGGAAAAGCTTTAGATACATCTCATACTAATGTTATGGCATATTCAAATTGCAAA GTAAGTGGTTCAAACACTTATGACGATTTGGCTGGAGCAGATGTAGTAATAGTAACAGCT GGATTTACCAAGGCCCCAGGAAAGAGTGACAAAGAATGGAATAGAGATGATTTATTACCA TTAAACAACAAGATTATGATTGAAATTGGTGGTCATATTAAGAAGAATTGTCCAAATGCT TTTATTATTGTTGTAACAAACCCAGTAGATGTTATGGTACAATTATTACATCAACATTCA GGTGTTCCTAAAAACAAGATTATTGGTTTAGGTGGTGTATTAGATACATCAAGATTGAAG TATTACATATCTCAGAAATTAAATGTATGCCCAAGAGATGTAAATGCACACATTGTAGGT GCTCATGGAAATAAAATGGTTCTTTTAAAAAGATACATTACTGTAGGTGGTATCCCTTTA CAAGAATTTATTAATAACAAGTTAATTTCTGATGCTGAATTAGAAGCTATATTTGATAGA ACTGTTAATACTGCATTAGAAATTGTAAACTTACATGCATCACCATATGTTGCACCAGCT GCTGCTATTATCGAAATGGCTGAATCCTACTTAAAAGATTTGAAAAAAGTATTAATTTGC TCAACCTTGTTAGAAGGACAATATGGACACTCCGATATATTCGGTGGTACACCTGTTGTT TTAGGTGCTAATGGTGTTGAACAAGTTATCGAATTACAATTAAATAGTGAGGAAAAAGCT AAATTTGATGAAGCCATAGCTGAAACTAAGAGAATGAAGGCATTAGCTTAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q27743 UniProtKB Entry Name LDH_PLAFD GenBank Protein ID 294165 GenBank Gene ID M93720 - General References
- Bzik DJ, Fox BA, Gonyer K: Expression of Plasmodium falciparum lactate dehydrogenase in Escherichia coli. Mol Biochem Parasitol. 1993 May;59(1):155-66. [Article]
- Dunn CR, Banfield MJ, Barker JJ, Higham CW, Moreton KM, Turgut-Balik D, Brady RL, Holbrook JJ: The structure of lactate dehydrogenase from Plasmodium falciparum reveals a new target for anti-malarial design. Nat Struct Biol. 1996 Nov;3(11):912-5. [Article]
- Read JA, Wilkinson KW, Tranter R, Sessions RB, Brady RL: Chloroquine binds in the cofactor binding site of Plasmodium falciparum lactate dehydrogenase. J Biol Chem. 1999 Apr 9;274(15):10213-8. [Article]
Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB02111 3-hydroxyisoxazole-4-carboxylic acid experimental unknown Details DB02401 4-Hydroxy-1,2,5-oxadiazole-3-carboxylic acid experimental unknown Details DB03162 4-oxo-4,5-dihydro-1,2,5-thiadiazole-3-carboxylic acid experimental unknown Details DB03940 Oxamic Acid experimental unknown Details DB04640 Naphthalene-2,6-disulfonic acid experimental unknown Details DB04641 3,7-DIHYDROXYNAPHTHALENE-2-CARBOXYLIC ACID experimental unknown Details DB11638 Artenimol approved, experimental, investigational unknown ligand Details