Quinohemoprotein ethanol dehydrogenase type-1
Details
- Name
- Quinohemoprotein ethanol dehydrogenase type-1
- Synonyms
- 1.1.9.1
- Alcohol dehydrogenase (azurin)
- QH-EDH1
- Quinohemoprotein ethanol dehydrogenase type I
- Gene Name
- qheDH
- Organism
- Comamonas testosteroni
- Amino acid sequence
>lcl|BSEQ0019194|Quinohemoprotein ethanol dehydrogenase type-1 MERLIDNSHGWPGRMVWLLAACLGSAAAFAQTGPAAQAAAAVQRVDGDFIRANAARTPDW PTIGVDYAETRYSRLDQINAANVKDLGLAWSYNLESTRGVEATPVVVDGIMYVSASWSVV HAIDTRTGNRIWTYDPQIDRSTGFKGCCDVVNRGVALWKGKVYVGAWDGRLIALDAATGK EVWHQNTFEGQKGSLTITGAPRVFKGKVIIGKRGAEYGVRGYITAYDAETGERKWRWFSV PGDPSKPFEDESMKRAARTWDPSGKWWEAGGGGTMWDSMTFDAELNTMYVGTGNGSPWSH KVRSPKGGDNLYLASIVALDPDTGKYKWHYQETPGDNWDYTSTQPMILADIKIAGKPRKV ILHAPKNGFFFVLDRTNGKFISAKNFVPVNWASGYDKHGKPIGIAAARDGSKPQDAVPGP YGAHNWHPMSFNPQTGLVYLPAQNVPVNLMDDKKWEFNQAGPGKPQSGTGWNTAKFFNAE PPKSKPFGRLLAWDPVAQKAAWSVEHVSPWNGGTLTTAGNVVFQGTADGRLVAYHAATGE KLWEAPTGTGVVAAPSTYMVDGRQYVSVAVGWGGVYGLAARATERQGPGTVYTFVVAGKA RMPEFVAQRTGQLLQGVKYDPAKVEAGTMLYVANCVFCHGVPGVDRGGNIPNLGYMDASY IENLPNFVFKGPAMVRGMPDFTGKLSGDDVESLKAFIQGTADAIRPKP
- Number of residues
- 708
- Molecular Weight
- 76822.435
- Theoretical pI
- 9.21
- GO Classification
- Functionscalcium ion binding / electron carrier activity / heme binding / oxidoreductase activity, acting on CH-OH group of donorsComponentsmembrane / outer membrane-bounded periplasmic space
- General Function
- Oxidoreductase activity, acting on ch-oh group of donors
- Specific Function
- Catalyzes the dye-linked oxidation of primary alcohols to the corresponding aldehydes and the (subsequent) oxidation of the aldehydes to carboxylic acids.
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Periplasm
- Gene sequence
>lcl|BSEQ0003704|2127 bp ATGGAACGGCTGATCGACAACTCTCATGGATGGCCGGGCCGCATGGTCTGGCTGCTGGCC GCCTGCCTGGGCAGCGCAGCGGCTTTCGCGCAAACCGGCCCTGCAGCGCAGGCTGCTGCT GCCGTGCAGCGCGTCGACGGCGATTTCATCCGCGCCAATGCCGCCAGGACGCCTGACTGG CCCACCATCGGCGTGGACTATGCCGAGACCCGCTACAGCCGCCTCGATCAGATCAATGCC GCCAACGTCAAGGACCTGGGCCTGGCATGGTCGTACAACCTCGAGTCCACGCGCGGCGTG GAGGCCACGCCTGTCGTGGTGGACGGCATCATGTATGTCAGCGCCTCATGGAGCGTGGTG CATGCCATCGACACCCGTACCGGCAACAGGATCTGGACCTATGACCCGCAGATCGACCGC AGCACCGGCTTCAAGGGGTGCTGCGACGTCGTCAACCGCGGCGTGGCGCTGTGGAAGGGC AAGGTCTATGTGGGGGCGTGGGATGGCCGCCTGATCGCGCTGGATGCCGCCACCGGCAAG GAGGTCTGGCACCAAAATACCTTCGAGGGGCAGAAGGGGTCGCTCACCATCACCGGCGCC CCGCGCGTGTTCAAGGGCAAGGTCATCATCGGCAAACGCGGCGCCGAATATGGCGTGCGC GGCTATATCACTGCCTATGACGCCGAGACCGGGGAGCGGAAATGGCGCTGGTTCAGCGTA CCCGGCGATCCCTCCAAACCCTTCGAGGACGAGTCCATGAAGCGCGCCGCCAGGACCTGG GACCCCAGCGGCAAATGGTGGGAGGCCGGCGGCGGCGGCACCATGTGGGACAGCATGACC TTCGATGCCGAACTCAACACCATGTACGTGGGCACGGGCAATGGATCGCCCTGGTCGCAC AAGGTGCGCAGCCCCAAGGGCGGCGACAACCTGTACCTGGCCTCCATCGTGGCCCTGGAT CCCGACACCGGCAAATACAAGTGGCACTATCAGGAAACACCGGGCGACAACTGGGACTAC ACCTCCACCCAGCCCATGATCCTGGCCGACATCAAGATCGCCGGCAAGCCGCGCAAGGTC ATACTGCATGCGCCCAAGAACGGCTTCTTCTTCGTGCTCGACCGCACCAATGGAAAGTTC ATCTCGGCCAAGAACTTCGTGCCCGTGAACTGGGCCAGCGGCTACGACAAGCACGGCAAG CCCATCGGCATTGCCGCAGCGCGCGACGGCAGCAAGCCCCAGGACGCGGTGCCGGGCCCC TATGGCGCGCACAACTGGCACCCCATGTCCTTCAACCCCCAGACGGGCCTGGTGTATCTG CCTGCGCAGAACGTGCCCGTCAACCTGATGGACGACAAGAAATGGGAGTTCAACCAGGCC GGACCGGGCAAGCCCCAGTCGGGCACCGGCTGGAACACGGCCAAGTTCTTCAATGCCGAG CCGCCCAAGAGCAAGCCCTTTGGTCGTCTGCTGGCCTGGGACCCCGTTGCGCAAAAGGCC GCCTGGAGCGTGGAGCATGTCTCGCCCTGGAACGGCGGCACGCTGACCACGGCGGGCAAT GTGGTGTTCCAGGGAACGGCTGATGGCCGCCTCGTGGCCTATCACGCGGCCACGGGCGAG AAACTGTGGGAAGCGCCCACGGGCACCGGTGTGGTGGCCGCGCCCAGCACCTATATGGTG GACGGCAGGCAGTATGTCTCGGTGGCCGTGGGCTGGGGCGGTGTCTACGGTCTGGCTGCG CGCGCCACCGAGCGCCAGGGCCCGGGCACGGTCTATACCTTCGTCGTGGCCGGCAAGGCC AGGATGCCGGAGTTCGTGGCCCAGCGCACCGGCCAGTTGCTGCAGGGCGTGAAATACGAC CCCGCCAAGGTCGAGGCCGGCACCATGCTGTATGTGGCCAACTGCGTTTTCTGTCACGGC GTGCCTGGCGTGGACCGTGGCGGAAACATTCCCAATCTGGGTTACATGGACGCGAGCTAT ATCGAGAACCTGCCAAACTTTGTCTTCAAGGGCCCGGCCATGGTGCGCGGCATGCCGGAC TTCACGGGCAAGTTGTCGGGCGATGACGTGGAGTCCCTCAAGGCCTTCATCCAGGGCACG GCGGACGCCATCCGGCCCAAGCCCTGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q46444 UniProtKB Entry Name QHED_COMTE GenBank Protein ID 663196 GenBank Gene ID X81880 - General References
- Stoorvogel J, Kraayveld DE, Van Sluis CA, Jongejan JA, De Vries S, Duine JA: Characterization of the gene encoding quinohaemoprotein ethanol dehydrogenase of Comamonas testosteroni. Eur J Biochem. 1996 Feb 1;235(3):690-8. [Article]
- de Jong GA, Geerlof A, Stoorvogel J, Jongejan JA, de Vries S, Duine JA: Quinohaemoprotein ethanol dehydrogenase from Comamonas testosteroni. Purification, characterization, and reconstitution of the apoenzyme with pyrroloquinoline quinone analogues. Eur J Biochem. 1995 Jun 15;230(3):899-905. [Article]
- Groen BW, van Kleef MA, Duine JA: Quinohaemoprotein alcohol dehydrogenase apoenzyme from Pseudomonas testosteroni. Biochem J. 1986 Mar 15;234(3):611-5. [Article]
- Oubrie A, Huizinga EG, Rozeboom HJ, Kalk KH, de Jong GA, Duine JA, Dijkstra BW: Crystallization of quinohaemoprotein alcohol dehydrogenase from Comamonas testosteroni: crystals with unique optical properties. Acta Crystallogr D Biol Crystallogr. 2001 Nov;57(Pt 11):1732-4. Epub 2001 Oct 25. [Article]
- Oubrie A, Rozeboom HJ, Kalk KH, Huizinga EG, Dijkstra BW: Crystal structure of quinohemoprotein alcohol dehydrogenase from Comamonas testosteroni: structural basis for substrate oxidation and electron transfer. J Biol Chem. 2002 Feb 1;277(5):3727-32. Epub 2001 Nov 19. [Article]