Proton-coupled amino acid transporter 1
Details
- Name
- Proton-coupled amino acid transporter 1
- Synonyms
- PAT1
- Proton/amino acid transporter 1
- Solute carrier family 36 member 1
- Gene Name
- SLC36A1
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0001070|Proton-coupled amino acid transporter 1 MSTQRLRNEDYHDYSSTDVSPEESPSEGLNNLSSPGSYQRFGQSNSTTWFQTLIHLLKGN IGTGLLGLPLAVKNAGIVMGPISLLIIGIVAVHCMGILVKCAHHFCRRLNKSFVDYGDTV MYGLESSPCSWLRNHAHWGRRVVDFFLIVTQLGFCCVYFVFLADNFKQVIEAANGTTNNC HNNETVILTPTMDSRLYMLSFLPFLVLLVFIRNLRALSIFSLLANITMLVSLVMIYQFIV QRIPDPSHLPLVAPWKTYPLFFGTAIFSFEGIGMVLPLENKMKDPRKFPLILYLGMVIVT ILYISLGCLGYLQFGANIQGSITLNLPNCWLYQSVKLLYSIGIFFTYALQFYVPAEIIIP FFVSRAPEHCELVVDLFVRTVLVCLTCILAILIPRLDLVISLVGSVSSSALALIIPPLLE VTTFYSEGMSPLTIFKDALISILGFVGFVVGTYEALYELIQPSNAPIFINSTCAFI
- Number of residues
- 476
- Molecular Weight
- 53075.045
- Theoretical pI
- 7.0
- GO Classification
- Functionsglycine transmembrane transporter activity / hydrogen / hydrogen ion transmembrane transporter activity / L-alanine transmembrane transporter activity / L-proline transmembrane transporter activityProcessesamino acid transport / glycine transport / hydrogen ion transmembrane transport / ion transport / L-alanine transport / proline transmembrane transport / proton transport / transmembrane transportComponentsendoplasmic reticulum / integral component of membrane / lysosomal membrane / plasma membrane
- General Function
- L-proline transmembrane transporter activity
- Specific Function
- Neutral amino acid/proton symporter. Has a pH-dependent electrogenic transport activity for small amino acids such as glycine, alanine and proline. Besides small apolar L-amino acids, it also recognize their D-enantiomers and selected amino acid derivatives such as gamma-aminobutyric acid (By similarity).
- Pfam Domain Function
- Aa_trans (PF01490)
- Transmembrane Regions
- 52-72 79-99 142-162 191-211 216-236 258-278 290-310 343-363 373-393 398-418 440-460
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0020464|Proton-coupled amino acid transporter 1 (SLC36A1) ATGTCCACGCAGAGACTTCGGAATGAAGACTACCACGACTACAGCTCCACGGACGTGAGC CCTGAGGAGAGCCCGTCGGAAGGCCTCAACAACCTCTCCTCCCCGGGCTCCTACCAGCGC TTTGGTCAAAGCAATAGCACAACATGGTTCCAGACCTTGATCCACCTGTTAAAAGGCAAC ATTGGCACAGGACTCCTGGGACTCCCTCTGGCGGTGAAAAATGCAGGCATCGTGATGGGT CCCATCAGCCTGCTGATCATAGGCATCGTGGCCGTGCACTGCATGGGTATCCTGGTGAAA TGTGCTCACCACTTCTGCCGCAGGCTGAATAAATCCTTTGTGGATTATGGTGATACTGTG ATGTATGGACTAGAATCCAGCCCCTGCTCCTGGCTCCGGAACCACGCACACTGGGGAAGA CGTGTTGTGGACTTCTTCCTGATTGTCACCCAGCTGGGATTCTGCTGTGTCTATTTTGTG TTTCTGGCTGACAACTTTAAACAGGTGATAGAAGCGGCCAATGGGACCACCAATAACTGC CACAACAATGAGACGGTGATTCTGACGCCTACCATGGACTCGCGACTCTACATGCTCTCC TTCCTGCCCTTCCTGGTGCTGCTGGTTTTCATCAGGAACCTCCGAGCCCTGTCCATCTTC TCCCTGTTGGCCAACATCACCATGCTGGTCAGCTTGGTCATGATCTACCAGTTCATTGTT CAGAGGATCCCAGACCCCAGCCACCTCCCCTTGGTGGCCCCTTGGAAGACCTACCCTCTC TTCTTTGGCACAGCGATTTTTTCATTTGAAGGCATTGGAATGGTTCTGCCCCTGGAAAAC AAAATGAAGGATCCTCGGAAGTTCCCACTCATCCTGTACCTGGGCATGGTCATCGTCACC ATCCTCTACATCAGCCTGGGGTGTCTGGGGTACCTGCAATTTGGAGCTAATATCCAAGGC AGCATAACCCTCAACCTGCCCAACTGCTGGTTGTACCAGTCAGTTAAGCTGCTGTACTCC ATCGGGATCTTTTTCACCTACGCACTCCAGTTCTACGTCCCGGCTGAGATCATCATCCCC TTCTTTGTGTCCCGAGCGCCCGAGCACTGTGAGTTAGTGGTGGACCTGTTTGTGCGCACA GTGCTGGTCTGCCTGACATGA
- Chromosome Location
- 5
- Locus
- 5q33.1
- External Identifiers
Resource Link UniProtKB ID Q7Z2H8 UniProtKB Entry Name S36A1_HUMAN GenBank Protein ID 31324239 GenBank Gene ID AF516142 GenAtlas ID SLC36A1 HGNC ID HGNC:18761 - General References
- Boll M, Foltz M, Rubio-Aliaga I, Daniel H: A cluster of proton/amino acid transporter genes in the human and mouse genomes. Genomics. 2003 Jul;82(1):47-56. [Article]
- Chen Z, Fei YJ, Anderson CM, Wake KA, Miyauchi S, Huang W, Thwaites DT, Ganapathy V: Structure, function and immunolocalization of a proton-coupled amino acid transporter (hPAT1) in the human intestinal cell line Caco-2. J Physiol. 2003 Jan 15;546(Pt 2):349-61. [Article]
- Bermingham JR Jr, Pennington J: Organization and expression of the SLC36 cluster of amino acid transporter genes. Mamm Genome. 2004 Feb;15(2):114-25. [Article]
- Bechtel S, Rosenfelder H, Duda A, Schmidt CP, Ernst U, Wellenreuther R, Mehrle A, Schuster C, Bahr A, Blocker H, Heubner D, Hoerlein A, Michel G, Wedler H, Kohrer K, Ottenwalder B, Poustka A, Wiemann S, Schupp I: The full-ORF clone resource of the German cDNA Consortium. BMC Genomics. 2007 Oct 31;8:399. [Article]
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- Schroder B, Wrocklage C, Pan C, Jager R, Kosters B, Schafer H, Elsasser HP, Mann M, Hasilik A: Integral and associated lysosomal membrane proteins. Traffic. 2007 Dec;8(12):1676-86. Epub 2007 Sep 26. [Article]
- Dorn M, Weiwad M, Markwardt F, Laug L, Rudolph R, Brandsch M, Bosse-Doenecke E: Identification of a disulfide bridge essential for transport function of the human proton-coupled amino acid transporter hPAT1. J Biol Chem. 2009 Aug 14;284(33):22123-32. doi: 10.1074/jbc.M109.023713. Epub 2009 Jun 23. [Article]
Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB00160 Alanine nutraceutical unknown Details DB06554 Gaboxadol investigational unknown substrate Details DB08847 Hydroxyproline experimental unknown Details DB02853 D-Proline experimental unknown Details DB01080 Vigabatrin approved unknown substrate Details DB08849 Nipecotic acid experimental unknown Details DB02530 gamma-Aminobutyric acid approved, investigational unknown Details DB08835 Spaglumic acid experimental unknown substrateother Details DB01956 Taurine approved, nutraceutical no substrate Details DB00563 Methotrexate approved unknown substrate Details DB00145 Glycine approved, nutraceutical, vet_approved unknown substrate Details