Methylmalonyl-CoA carboxyltransferase 12S subunit
Details
- Name
- Methylmalonyl-CoA carboxyltransferase 12S subunit
- Synonyms
- 2.1.3.1
- Transcarboxylase 12S subunit
- Gene Name
- Not Available
- Organism
- Propionibacterium freudenreichii subsp. shermanii
- Amino acid sequence
>lcl|BSEQ0003529|Methylmalonyl-CoA carboxyltransferase 12S subunit MAENNNLKLASTMEGRVEQLAEQRQVIEAGGGERRVEKQHSQGKQTARERLNNLLDPHSF DEVGAFRKHRTTLFGMDKAVVPADGVVTGRGTILGRPVHAASQDFTVMGGSAGETQSTKV VETMEQALLTGTPFLFFYDSGGARIQEGIDSLSGYGKMFFANVKLSGVVPQIAIIAGPCA GGASYSPALTDFIIMTKKAHMFITGPQVIKSVTGEDVTADELGGAEAHMAISGNIHFVAE DDDAAELIAKKLLSFLPQNNTEEASFVNPNNDVSPNTELRDIVPIDGKKGYDVRDVIAKI VDWGDYLEVKAGYATNLVTAFARVNGRSVGIVANQPSVMSGCLDINASDKAAEFVNFCDS FNIPLVQLVDVPGFLPGVQQEYGGIIRHGAKMLYAYSEATVPKITVVLRKAYGGSYLAMC NRDLGADAVYAWPSAEIAVMGAEGAANVIFRKEIKAADDPDAMRAEKIEEYQNAFNTPYV AAARGQVDDVIDPADTRRKIASALEMYATKRQTRPAKKPWKLPLLSEEEIMADEEEKDLM IATLNKRVASLESELGSLQSDTQGVTEDVLTAISAVAAYLGNDGSAEVVHFAPSPNWVRE GRRALQNHSIR
- Number of residues
- 611
- Molecular Weight
- 65926.0
- Theoretical pI
- 4.86
- GO Classification
- Functionsacetyl-CoA carboxylase activity / methylmalonyl-CoA carboxytransferase activityProcessesfatty acid biosynthetic processComponentsacetyl-CoA carboxylase complex
- General Function
- Methylmalonyl-coa carboxytransferase activity
- Specific Function
- The 12S subunit specifically catalyzes the transfer of the carboxyl group of methylmalonyl CoA to the biotin of the 1.3S subunit forming propanoyl-CoA and carboxylated 1.3S-biotin.
- Pfam Domain Function
- Carboxyl_trans (PF01039)
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0003528|1818 bp ATGGCTGAAAACAACAATTTGAAGCTCGCCAGCACCATGGAAGGTCGCGTGGAGCAGCTC GCAGAGCAGCGCCAGGTGATCGAAGCCGGTGGCGGCGAACGTCTCGTCGAGAAGCAACAT TCCCAGGGTAAGCAGACCGCTCGTGAGCGCCTGAACAACCTGCTCGATCCCCATTCGTTC GACGAGGTCGGCGCTTTCCGCAAGCACCGCACCACGTTGTTCGGCATGGACAAGGCCGTC GTCCCGGCAGATGGCGTGGTCACCGGCCGTGGCACCATCCTTGGTCGTCCCGTGCACGCC GCGTCCCAGGACTTCACGGTCATGGGTGGTTCGGCTTGGCGAGACGCAGTCCACGAAGGT CGTCGAGACGATGGAACAGCGCTGCTCACCGGCACGCCCTTCCTGTTCTTCTACGATTCG GGCGGCCGGATCCAGGAGGGCATCGACTCGCTGAGCGGTTACGGCAAGATGTTCTTCGCC AACGTGAAGCTGTCGGGCGTCGTGCCGCAGATCGCCATCATTGCCGGCCCCTGTGCGTGC GCCTCGTATTCGCCGGCACTGACTGACTTCATCATCATGACCAAGAAGGCCCATATGTTC ATCACGGGCCCCCAGGTCATCAAGTCGGTCACCGGCGAGGATGTCACCGCTGACGAACTC GGTGGCGCTGAGCCCATATGGCCATCTCGGGCAATATACTTCGTGGCCGAGGACGACGAC GCCGCGGAGCTCATTGCCAAGAAGCTGCTGAGCTTCCTTCCGCAGAACAACACTGAGGAA GCATCCTTCGTCAACCCGAACAATGACGTCAGCCCCAATACCGAGCTGCGCGACATCGTT CCGATTGACGGCAAGAAGGGCTATGACGTGCGCGATGTCATTGCCAAGATCGTCGACTGG GGTGACTACCTCGAGGTCAAGGCCGGCTATGCCACCAACCTCGTGACCGCCTTCGCCCGG GTCAATGGTCGTTCGGTGGGCATCGTGGCCAATCAGCCTTCGGTGATGTCGGGTTGCCTC GACATCAACGCCTCTGACAAGGCCGCCGAATTCGTGAATTTCTGCGATTCGTTCAACATC CCGCTGGTGCAGCTGGTCGACGTGCCGGGCTTCCTGCCCGTGCAGCAGGAGTACGGCGGC ATCATTCGCCATGGGCGCAAGATGCTGTACGCCTACTCCGAGGCCACCGTGCCGAAGATC ACGTGTCTCGCAACGCCTACGGCGGCTCCTACCTGGCCATGTGCAACCGTGACCTTGGTG CCGACGCCGTGTACGCCTGTGCCCAGCGCCGAGATTGCGGTGATGGGCGCCGAGGGTGCG GCAAATGTGATCTTCCGCAAGGAGATCAAGGCTGCCGACGATCCCGACGCCATGCGCGCC GAGAAGATCGAGGAGTACCAGAACGGTTCAACACGCCGTACGTGGCGCGCCCGCGGTCAG GTCGACGACGTGATTGACCCGGCTGATACCCGTCGAAAGATTGCTTCCGCCCTGGAGATG TACGCCACCAAGCGTCAGACCCGCCCGGCGAAGAAGCCATGGAAACTTCCCCTGCTGAGC GAGGAGGAAATTATGGCTGATGAGGAAGAGAAGGACCTGATGATCGCCACGCTCAACAAG CGCGTCGCGTCATTGGAGTCTGAGTTGGGTTCACTCCAGAGCGATACCCAGGGTGTCACC GAGGACGTACTGACGGCCATTTCGGCCGTTGCGGCCTATCTCGGCAACGATGGATCGGCT GAGGTCGTCCATTTCGCCCCGAGCCCGAACTGGGTCCGCGAGGGTCGTCGGGCTCTGCAG AACCATTCCATTCGTTGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q8GBW6 UniProtKB Entry Name 12S_PROFR GenBank Protein ID 150933 GenBank Gene ID L04196 - General References
- Thornton CG, Kumar GK, Haase FC, Phillips NF, Woo SB, Park VM, Magner WJ, Shenoy BC, Wood HG, Samols D: Primary structure of the monomer of the 12S subunit of transcarboxylase as deduced from DNA and characterization of the product expressed in Escherichia coli. J Bacteriol. 1993 Sep;175(17):5301-8. [Article]
- Hall PR, Wang YF, Rivera-Hainaj RE, Zheng X, Pustai-Carey M, Carey PR, Yee VC: Transcarboxylase 12S crystal structure: hexamer assembly and substrate binding to a multienzyme core. EMBO J. 2003 May 15;22(10):2334-47. [Article]