Multiple coagulation factor deficiency protein 2
Details
- Name
- Multiple coagulation factor deficiency protein 2
- Synonyms
- Neural stem cell-derived neuronal survival protein
- SDNSF
- Gene Name
- MCFD2
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0004158|Multiple coagulation factor deficiency protein 2 MTMRSLLRTPFLCGLLWAFCAPGARAEEPAASFSQPGSMGLDKNTVHDQEHIMEHLEGVI NKPEAEMSPQELQLHYFKMHDYDGNNLLDGLELSTAITHVHKEEGSEQAPLMSEDELINI IDGVLRDDDKNNDGYIDYAEFAKSLQ
- Number of residues
- 146
- Molecular Weight
- 16390.175
- Theoretical pI
- 4.25
- GO Classification
- Functionscalcium ion bindingProcessescellular protein metabolic process / COPII vesicle coating / ER to Golgi vesicle-mediated transport / membrane organization / post-translational protein modification / protein N-linked glycosylation via asparagine / protein transportComponentsendoplasmic reticulum membrane / endoplasmic reticulum-Golgi intermediate compartment membrane / ER to Golgi transport vesicle membrane / Golgi membrane
- General Function
- Calcium ion binding
- Specific Function
- The MCFD2-LMAN1 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins. Plays a role in the secretion of coagulation factors.
- Pfam Domain Function
- EF-hand_7 (PF13499)
- Transmembrane Regions
- Not Available
- Cellular Location
- Endoplasmic reticulum-Golgi intermediate compartment
- Gene sequence
>lcl|BSEQ0016687|Multiple coagulation factor deficiency protein 2 (MCFD2) ATGACCATGAGATCCCTGCTCAGAACCCCCTTCCTGTGTGGCCTGCTCTGGGCCTTTTGT GCCCCAGGCGCCAGGGCTGAGGAGCCTGCAGCCAGCTTCTCCCAACCCGGCAGCATGGGC CTGGATAAGAACACAGTGCACGACCAAGAGCATATCATGGAGCATCTAGAAGGTGTCATC AACAAACCAGAGGCGGAGATGTCGCCACAAGAATTGCAGCTCCATTACTTCAAAATGCAT GATTATGATGGCAATAATTTGCTTGATGGCTTAGAACTCTCCACAGCCATCACTCATGTC CATAAGGAGGAAGGGAGTGAACAGGCACCACTAATGAGTGAAGATGAACTGATTAACATA ATAGATGGTGTTTTGAGAGATGATGACAAGAACAATGATGGATACATTGACTATGCTGAA TTTGCAAAATCACTGCAGTAG
- Chromosome Location
- 2
- Locus
- 2p21
- External Identifiers
Resource Link UniProtKB ID Q8NI22 UniProtKB Entry Name MCFD2_HUMAN GenBank Protein ID 20799383 GenBank Gene ID AF475284 GenAtlas ID MCFD2 HGNC ID HGNC:18451 - General References
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