2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Details
- Name
- 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
- Synonyms
- 4.6.1.12
- MECDP-synthase
- Gene Name
- ispF
- Organism
- Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
- Amino acid sequence
>lcl|BSEQ0016497|2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase MRIGYGEDSHRLEEGRPLYLCGLLIPSPVGALAHSDGDAALHALTDALLSAYGLGDIGLL FPDTDPRWRGERSEVFLREALRLVEARGAKLLQASLVLTLDRPKLGPHRKALVDSLSRLL RLPQDRIGLTFKTSEGLAPSHVQARAVVLLDG
- Number of residues
- 152
- Molecular Weight
- 16519.835
- Theoretical pI
- 7.73
- GO Classification
- Functions2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity / metal ion bindingProcessesisopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway / terpenoid biosynthetic process
- General Function
- Metal ion binding
- Specific Function
- Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
- Pfam Domain Function
- YgbB (PF02542)
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0016498|2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (ispF) ATGCGCATCGGCTACGGCGAGGACAGCCACCGCCTGGAGGAGGGGAGGCCGCTTTACCTC TGCGGCCTCCTCATTCCAAGCCCCGTGGGGGCCCTGGCCCACTCCGATGGGGACGCCGCC CTCCACGCCCTCACCGACGCCCTCCTTTCCGCCTACGGCCTTGGGGACATCGGCCTCCTC TTCCCCGACACCGATCCCCGCTGGCGGGGCGAGCGGAGCGAGGTGTTTCTCCGGGAGGCC CTCCGCCTCGTGGAAGCGCGGGGGGCGAAGCTGCTTCAGGCGAGCCTCGTCCTCACCCTG GACCGGCCCAAGCTCGGCCCCCACCGCAAGGCCTTGGTGGACAGCCTATCCCGCCTCCTC CGCCTTCCCCAGGACCGCATTGGCCTCACCTTCAAGACCTCGGAGGGCCTGGCGCCTTCC CACGTCCAGGCCCGGGCGGTGGTGCTTCTGGATGGTTGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q8RQP5 UniProtKB Entry Name ISPF_THET8 GenBank Protein ID 19911566 GenBank Gene ID AB082126 - General References
- Kishida H, Wada T, Unzai S, Kuzuyama T, Takagi M, Terada T, Shirouzu M, Yokoyama S, Tame JR, Park SY: Structure and catalytic mechanism of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MECDP) synthase, an enzyme in the non-mevalonate pathway of isoprenoid synthesis. Acta Crystallogr D Biol Crystallogr. 2003 Jan;59(Pt 1):23-31. Epub 2002 Dec 19. [Article]