Neuronal acetylcholine receptor subunit alpha-10
Details
- Name
- Neuronal acetylcholine receptor subunit alpha-10
- Synonyms
- NACHR alpha-10
- NACHRA10
- Nicotinic acetylcholine receptor subunit alpha-10
- Gene Name
- CHRNA10
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0010285|Neuronal acetylcholine receptor subunit alpha-10 MGLRSHHLSLGLLLLFLLPAECLGAEGRLALKLFRDLFANYTSALRPVADTDQTLNVTLE VTLSQIIDMDERNQVLTLYLWIRQEWTDAYLRWDPNAYGGLDAIRIPSSLVWRPDIVLYN KADAQPPGSASTNVVLRHDGAVRWDAPAITRSSCRVDVAAFPFDAQHCGLTFGSWTHGGH QLDVRPRGAAASLADFVENVEWRVLGMPARRRVLTYGCCSEPYPDVTFTLLLRRRAAAYV CNLLLPCVLISLLAPLAFHLPADSGEKVSLGVTVLLALTVFQLLLAESMPPAESVPLIGK YYMATMTMVTFSTALTILIMNLHYCGPSVRPVPAWARALLLGHLARGLCVRERGEPCGQS RPPELSPSPQSPEGGAGPPAGPCHEPRCLCRQEALLHHVATIANTFRSHRAAQRCHEDWK RLARVMDRFFLAIFFSMALVMSLLVLVQAL
- Number of residues
- 450
- Molecular Weight
- 49704.295
- Theoretical pI
- 7.97
- GO Classification
- Functionsacetylcholine-activated cation-selective channel activity / calcium channel activity / receptor bindingProcessescation transmembrane transport / detection of mechanical stimulus involved in sensory perception of sound / inner ear morphogenesis / neurological system process / neuromuscular synaptic transmission / positive regulation of cytosolic calcium ion concentration / regulation of cell proliferation / regulation of membrane potential / response to nicotine / signal transduction / synaptic transmission, cholinergicComponentsacetylcholine-gated channel complex / axon / cell junction / cytosol / membrane / neuron projection / perikaryon / postsynaptic membrane / synapse
- General Function
- Receptor binding
- Specific Function
- Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma.
- Pfam Domain Function
- Transmembrane Regions
- 238-258 268-288 302-322 429-449
- Cellular Location
- Cell junction
- Gene sequence
>lcl|BSEQ0010286|Neuronal acetylcholine receptor subunit alpha-10 (CHRNA10) ATGCCGGCGCGGCGGCGCGTGCTCACCTACGGCTGCTGCTCCGAGCCCTACCCCGACGTC ACCTTCACGCTGCTGCTGCGCCGCCGCGCCGCCGCCTACGTGTGCAACCTGCTGCTGCCC TGCGTGCTCATCTCGCTGCTTGCGCCGCTCGCCTTCCACCTGCCTGCCGACTCAGGCGAG AAGGTGTCGCTGGGCGTCACCGTGCTGCTGGCGCTCACCGTCTTCCAGTTGCTGCTGGCC GAGAGCATGCCACCGGCCGAGAGCGTGCCGCTCATCGGGAAGTACTACATGGCCACTATG ACCATGGTCACATTCTCAACAGCACTCACCATCCTTATCATGAACCTGCATTACTGTGGT CCCAGTGTCCGCCCAGTGCCAGCCTGGGCTAGGGCCCTCCTGCTGGGACACCTGGCACGG GGCCTGTGCGTGCGGGAAAGAGGGGAGCCCTGTGGGCAGTCCAGGCCACCTGAGTTATCT CCTAGCCCCCAGTCGCCTGAAGGAGGGGCTGGCCCCCCAGCGGGCCCTTGCCACGAGCCA CGATGTCTGTGCCGCCAGGAAGCCCTACTGCACCACGTAGCCACCATTGCCAATACCTTC CGCAGCCACCGAGCTGCCCAGCGCTGCCATGAGGACTGGAAGCGCCTGGCCCGTGTGATG GACCGCTTCTTCCTGGCCATCTTCTTCTCCATGGCCCTGGTCATGAGCCTCCTGGTGCTG GTGCAGGCCCTGTGA
- Chromosome Location
- 11
- Locus
- 11p15.5
- External Identifiers
Resource Link UniProtKB ID Q9GZZ6 UniProtKB Entry Name ACH10_HUMAN GenBank Protein ID 12053839 GenBank Gene ID AJ278118 GenAtlas ID CHRNA10 HGNC ID HGNC:13800 - General References
- Sgard F, Charpantier E, Bertrand S, Walker N, Caput D, Graham D, Bertrand D, Besnard F: A novel human nicotinic receptor subunit, alpha10, that confers functionality to the alpha9-subunit. Mol Pharmacol. 2002 Jan;61(1):150-9. [Article]
- Lustig LR, Peng H, Hiel H, Yamamoto T, Fuchs PA: Molecular cloning and mapping of the human nicotinic acetylcholine receptor alpha10 (CHRNA10). Genomics. 2001 May 1;73(3):272-83. [Article]
- Peng H, Ferris RL, Matthews T, Hiel H, Lopez-Albaitero A, Lustig LR: Characterization of the human nicotinic acetylcholine receptor subunit alpha (alpha) 9 (CHRNA9) and alpha (alpha) 10 (CHRNA10) in lymphocytes. Life Sci. 2004 Dec 3;76(3):263-80. [Article]
Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB01090 Pentolinium approved yes antagonist Details DB01116 Trimethaphan approved, investigational yes antagonist Details DB00184 Nicotine approved unknown agonist Details DB05069 ATG003 investigational unknown Details DB05137 Lobeline investigational unknown Details DB05740 RPI-78M investigational unknown Details DB00898 Ethanol approved unknown Details DB14783 Diroximel fumarate approved, investigational unknown agonist Details DB00237 Butabarbital approved, illicit unknown inhibitor Details DB00202 Succinylcholine approved yes agonist Details DB00565 Cisatracurium approved, investigational yes antagonist Details