Pleckstrin homology domain-containing family A member 4
Details
- Name
- Pleckstrin homology domain-containing family A member 4
- Synonyms
- PEPP-1
- PEPP1
- PH domain-containing family A member 4
- Phosphoinositol 3-phosphate-binding protein 1
- Gene Name
- PLEKHA4
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0002543|Pleckstrin homology domain-containing family A member 4 MEGSRPRSSLSLASSASTISSLSSLSPKKPTRAVNKIHAFGKRGNALRRDPNLPVHIRGW LHKQDSSGLRLWKRRWFVLSGHCLFYYKDSREESVLGSVLLPSYNIRPDGPGAPRGRRFT FTAEHPGMRTYVLAADTLEDLRGWLRALGRASRAEGDDYGQPRSPARPQPGEGPGGPGGP PEVSRGEEGRISESPEVTRLSRGRGRPRLLTPSPTTDLHSGLQMRRARSPDLFTPLSRPP SPLSLPRPRSAPARRPPAPSGDTAPPARPHTPLSRIDVRPPLDWGPQRQTLSRPPTPRRG PPSEAGGGKPPRSPQHWSQEPRTQAHSGSPTYLQLPPRPPGTRASMVLLPGPPLESTFHQ SLETDTLLTKLCGQDRLLRRLQEEIDQKQEEKEQLEAALELTRQQLGQATREAGAPGRAW GRQRLLQDRLVSVRATLCHLTQERERVWDTYSGLEQELGTLRETLEYLLHLGSPQDRVSA QQQLWMVEDTLAGLGGPQKPPPHTEPDSPSPVLQGEESSERESLPESLELSSPRSPETDW GRPPGGDKDLASPHLGLGSPRVSRASSPEGRHLPSPQLGTKAPVARPRMSAQEQLERMRR NQECGRPFPRPTSPRLLTLGRTLSPARRQPDVEQRPVVGHSGAQKWLRSSGSWSSPRNTT PYLPTSEGHRERVLSLSQALATEASQWHRMMTGGNLDSQGDPLPGVPLPPSDPTRQETPP PRSPPVANSGSTGFSRRGSGRGGGPTPWGPAWDAGIAPPVLPQDEGAWPLRVTLLQSSF
- Number of residues
- 779
- Molecular Weight
- 85400.07
- Theoretical pI
- 11.12
- GO Classification
- Functions1-phosphatidylinositol bindingComponentscytoplasm / membrane
- General Function
- 1-phosphatidylinositol binding
- Specific Function
- Binds specifically to phosphatidylinositol 3-phosphate (PtdIns3P), but not to other phosphoinositides.
- Pfam Domain Function
- PH (PF00169)
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0016373|Pleckstrin homology domain-containing family A member 4 (PLEKHA4) ATGGAGGGGAGCCGACCTCGCAGCAGCCTGAGCCTGGCCAGCAGCGCCTCCACCATCTCC TCGCTCAGCAGCCTGAGCCCCAAGAAGCCCACCCGGGCAGTAAACAAGATCCACGCCTTT GGGAAGAGAGGCAATGCGCTCAGGAGGGATCCCAACCTTCCCGTGCACATCCGAGGCTGG CTTCATAAGCAGGACAGCTCGGGGCTCCGTCTCTGGAAACGCCGCTGGTTCGTCCTCTCC GGCCATTGCCTCTTTTATTACAAGGACAGCCGCGAGGAGAGTGTCCTAGGCAGCGTCCTG CTCCCCAGCTACAATATTAGACCAGATGGGCCGGGAGCCCCCCGAGGGCGGCGCTTCACC TTCACCGCAGAGCACCCGGGCATGAGGACCTACGTTTTGGCCGCTGACACCTTAGAAGAC CTGCGGGGCTGGCTACGGGCGCTGGGCCGGGCCTCCCGTGCGGAGGGGGACGACTATGGG CAACCCAGGTCACCTGCACGACCCCAGCCCGGGGAGGGCCCCGGCGGCCCCGGTGGTCCC CCGGAGGTGAGCAGAGGGGAAGAGGGGCGCATCTCAGAATCACCGGAAGTGACTCGACTC TCCAGAGGTCGTGGTAGACCCAGGCTGCTCACTCCCAGCCCCACAACCGACCTCCACTCT GGACTCCAGATGCGGAGGGCGAGGAGCCCCGACCTGTTCACCCCCCTCTCTCGCCCTCCC TCGCCTCTGAGCCTCCCCCGTCCCCGTTCTGCCCCTGCGCGGCGACCCCCTGCCCCCTCA GGAGACACAGCACCCCCTGCCCGACCTCACACCCCGTTGAGTCGCATTGATGTCCGACCT CCTCTGGATTGGGGCCCCCAACGCCAGACCCTCTCCCGACCCCCTACTCCCCGCCGAGGA CCTCCCTCTGAGGCTGGGGGAGGAAAGCCCCCCAGGAGTCCCCAGCACTGGAGTCAGGAG CCCAGAACACAGCCGGGTCCTCCCCTGGAGTCAACTTTCCACCAAAGCTTGGAGACAGAT ACGCTGCTGACCAAGTTGTGCGGGCAGGACCGGCTTCTGCGGAGGCTGCAGGAGGAGATA GACCAGAAGCAGGAGGAGAAGGAGCAACTAGAAGCAGCTCTGGAGTTGACCCGGCAACAG CTGGGCCAAGCCACCAGGGAGGCTGGGGCTCCCGGGAGGGCCTGGGGTCGCCAGCGCCTC TTGCAGGACCGGCTGGTCAGTGTGAGGGCCACCCTCTGTCACTTGACTCAGGAGCGAGAG AGGGTTTGGGACACGTACAGTGGCCTGGAGCAGGAGCTGGGCACCTTAAGAGAGACGCTG GAGTACCTGCTGCACCTTGGTTCTCCCCAGGACAGAGTGTCTGCTCAGCAGCAGCTGTGG ATGGTGGAAGACACGCTGGCAGGTCTGGGTGGCCCCCAGAAACCGCCCCCACACACTGAG CCTGACTCCCCATCTCCCGTGCTCCAGGGCGAGGAGTCCTCAGAGAGGGAGAGCCTGCCA GAGTCCTTGGAACTGAGCTCCCCTAGGTCCCCCGAGACTGACTGGGGGCGGCCTCCTGGA GGCGACAAAGACCTCGCCAGCCCTCACTTAGGTCTTGGGTCTCCGAGGGTCTCCCGGGCT TCCAGCCCTGAGGGTCGCCACCTCCCTTCCCCACAGCTAGGAACCAAGTCCAAGGAACAC CACCCCTTACTTGCCGACTTCCGAAGGTCACCGGGAGCGGGTTCTCAGCCTCTCCCAAGC CCTGGCTACTGA
- Chromosome Location
- 19
- Locus
- 19q13.33
- External Identifiers
Resource Link UniProtKB ID Q9H4M7 UniProtKB Entry Name PKHA4_HUMAN GenBank Protein ID 9992893 GenBank Gene ID AY007233 GenAtlas ID PLEKHA4 HGNC ID HGNC:14339 - General References
- Dowler S, Currie RA, Campbell DG, Deak M, Kular G, Downes CP, Alessi DR: Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities. Biochem J. 2000 Oct 1;351(Pt 1):19-31. [Article]
- Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
- Bian Y, Song C, Cheng K, Dong M, Wang F, Huang J, Sun D, Wang L, Ye M, Zou H: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics. 2014 Jan 16;96:253-62. doi: 10.1016/j.jprot.2013.11.014. Epub 2013 Nov 22. [Article]