Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide
Details
- Name
- Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide
- Synonyms
- B lymphocyte adapter protein Bam32
- B-cell adapter molecule of 32 kDa
- BAM32
- hDAPP1
- Gene Name
- DAPP1
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0002583|Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide MGRAELLEGKMSTQDPSDLWSRSDGEAELLQDLGWYHGNLTRHAAEALLLSNGCDGSYLL RDSNETTGLYSLSVRAKDSVKHFHVEYTGYSFKFGFNEFSSLKDFVKHFANQPLIGSETG TLMVLKHPYPRKVEEPSIYESVRVHTAMQTGRTEDDLVPTAPSLGTKEGYLTKQGGLVKT WKTRWFTLHRNELKYFKDQMSPEPIRILDLTECSAVQFDYSQERVNCFCLVFPFRTFYLC AKTGVEADEWIKILRWKLSQIRKQLNQGEGTIRSRSFIFK
- Number of residues
- 280
- Molecular Weight
- 32193.305
- Theoretical pI
- 7.92
- GO Classification
- Functionsphosphatidylinositol-3,4-bisphosphate binding / phosphatidylinositol-3,4,5-trisphosphate binding / phospholipid bindingProcessesprotein dephosphorylation / signal transductionComponentscytosol / plasma membrane
- General Function
- Phospholipid binding
- Specific Function
- May act as a B-cell-associated adapter that regulates B-cell antigen receptor (BCR)-signaling downstream of PI3K.
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0010907|Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide (DAPP1) ATGGGCAGAGCAGAACTTCTAGAAGGGAAGATGAGCACCCAGGATCCCTCAGATCTGTGG AGCAGATCCGATGGAGAGGCTGAGCTGCTCCAGGACTTGGGGTGGTATCACGGCAACCTC ACACGCCATGCTGCTGAAGCTCTTCTCCTCTCAAATGGATGTGACGGCAGCTACCTTCTG AGGGACAGCAATGAGACCACCGGGCTGTACTCTCTCTCTGTGAGGGCCAAAGATTCTGTT AAACACTTTCATGTTGAATATACTGGATATTCATTTAAATTTGGCTTTAATGAATTCTCA TCTTTGAAGGATTTTGTCAAGCATTTTGCAAATCAGCCTTTGATTGGAAGCGAGACAGGC ACTCTGATGGTTCTAAAACATCCCTACCCAAGAAAAGTGGAAGAACCCTCCATTTATGAA TCTGTCCGGGTTCACACAGCAATGCAGACAGGAAGAACAGAAGATGACCTTGTGCCCACA GCACCTTCTCTGGGCACCAAAGAAGGTTACCTCACCAAACAGGGAGGCCTGGTCAAGACC TGGAAAACAAGATGGTTTACTCTGCACAGGAATGAACTGAAATACTTCAAAGACCAGATG TCACCAGAACCAATTCGGATCCTAGACCTAACAGAATGTTCAGCTGTACAATTCGATTAT TCACAAGAAAGGGTAAACTGTTTTTGTTTGGTATTTCCATTCAGGACATTTTATCTCTGT GCAAAGACCGGAGTAGAAGCTGATGAGTGGATCAAGATATTACGCTGGAAATTGGTCAAG GACAAAAGCTGA
- Chromosome Location
- 4
- Locus
- 4q25-q27
- External Identifiers
Resource Link UniProtKB ID Q9UN19 UniProtKB Entry Name DAPP1_HUMAN GenBank Protein ID 5733600 GenBank Gene ID AF163254 GenAtlas ID DAPP1 HGNC ID HGNC:16500 - General References
- Dowler S, Currie RA, Downes CP, Alessi DR: DAPP1: a dual adaptor for phosphotyrosine and 3-phosphoinositides. Biochem J. 1999 Aug 15;342 ( Pt 1):7-12. [Article]
- Marshall AJ, Niiro H, Lerner CG, Yun TJ, Thomas S, Disteche CM, Clark EA: A novel B lymphocyte-associated adaptor protein, Bam32, regulates antigen receptor signaling downstream of phosphatidylinositol 3-kinase. J Exp Med. 2000 Apr 17;191(8):1319-32. [Article]
- Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. Genome Res. 2000 Oct;10(10):1546-60. [Article]
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- Ferguson KM, Kavran JM, Sankaran VG, Fournier E, Isakoff SJ, Skolnik EY, Lemmon MA: Structural basis for discrimination of 3-phosphoinositides by pleckstrin homology domains. Mol Cell. 2000 Aug;6(2):373-84. [Article]