NADPH oxidase 1
Details
- Name
- NADPH oxidase 1
- Synonyms
- 1.-.-.-
- Mitogenic oxidase 1
- MOX-1
- MOX1
- NADH/NADPH mitogenic oxidase subunit P65-MOX
- NOH-1
- NOH1
- NOX-1
- Gene Name
- NOX1
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0009830|NADPH oxidase 1 MGNWVVNHWFSVLFLVVWLGLNVFLFVDAFLKYEKADKYYYTRKILGSTLACARASALCL NFNSTLILLPVCRNLLSFLRGTCSFCSRTLRKQLDHNLTFHKLVAYMICLHTAIHIIAHL FNFDCYSRSRQATDGSLASILSSLSHDEKKGGSWLNPIQSRNTTVEYVTFTSIAGLTGVI MTIALILMVTSATEFIRRSYFEVFWYTHHLFIFYILGLGIHGIGGIVRGQTEESMNESHP RKCAESFEMWDDRDSHCRRPKFEGHPPESWKWILAPVILYICERILRFYRSQQKVVITKV VMHPSKVLELQMNKRGFSMEVGQYIFVNCPSISLLEWHPFTLTSAPEEDFFSIHIRAAGD WTENLIRAFEQQYSPIPRIEVDGPFGTASEDVFQYEVAVLVGAGIGVTPFASILKSIWYK FQCADHNLKTKKIYFYWICRETGAFSWFNNLLTSLEQEMEELGKVGFLNYRLFLTGWDSN IVGHAALNFDKATDIVTGLKQKTSFGRPMWDNEFSTIATSHPKSVVGVFLCGPRTLAKSL RKCCHRYSSLDPRKVQFYFNKENF
- Number of residues
- 564
- Molecular Weight
- 64870.455
- Theoretical pI
- Not Available
- GO Classification
- Functionsmetal ion binding / NADP binding / Rac GTPase binding / superoxide-generating NADPH oxidase activity / voltage-gated proton channel activityProcessesangiogenesis / cell migration / cellular response to hyperoxia / cellular stress response to acidic pH / extracellular matrix organization / hydrogen peroxide metabolic process / inflammatory response / intracellular pH elevation / NADP metabolic process / oxidation-reduction process / oxygen metabolic process / positive regulation of cell proliferation / positive regulation of integrin biosynthetic process / positive regulation of JNK cascade / positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway / positive regulation of smooth muscle cell proliferation / positive regulation of vascular endothelial growth factor production / proton transport / regulation of blood pressure / regulation of systemic arterial blood pressure by renin-angiotensin / respiratory burst / signal transduction / small GTPase mediated signal transduction / superoxide anion generation / superoxide metabolic processComponentscell junction / early endosome / integral component of membrane / invadopodium membrane / NADPH oxidase complex / plasma membrane
- General Function
- Voltage-gated proton channel activity
- Specific Function
- NOH-1S is a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes and other tissues. It participates in the regulation of cellular pH and is blocked by zinc. NOH-1L is a pyridine nucleotide-dependent oxidoreductase that generates superoxide and might conduct H(+) ions as part of its electron transport mechanism, whereas NOH-1S does not contain an electron transport chain.
- Pfam Domain Function
- Transmembrane Regions
- 10-30 45-72 103-123 169-189 207-227 397-417
- Cellular Location
- Cell projection
- Gene sequence
>lcl|BSEQ0017844|NADPH oxidase 1 (NOX1) ATGGGAAACTGGGTGGTTAACCACTGGTTTTCAGTTTTGTTTCTGGTTGTTTGGTTAGGG CTGAATGTTTTCCTGTTTGTGGATGCCTTCCTGAAATATGAGAAGGCCGACAAATACTAC TACACAAGAAAAATCCTTGGGTTTTGCAGCCGCACACTGAGAAAGCAATTGGATCACAAC CTCACCTTCCACAAGCTGGTGGCCTATATGATCTGCCTACATACAGCTATTCACATCATT GCACACCTGTTTAACTTTGACTGCTATAGCAGAAGCCGACAGGCCACAGATGGCTCCCTT GCCTCCATTCTCTCCAGCCTATCTCATGATGAGAAAAAGGGGGGTTCTTGGCTAAATCCC ATCCAGTCCCGAAACACGACAGTGGAGTATGTGACATTCACCAGCATTGCTGGTCTCACT GGAGTGATCATGACAATAGCCTTGATTCTCATGGTAACTTCAGCTACTGAGTTCATCCGG AGGAGTTATTTTGAAGTCTTCTGGTATACTCACCACCTTTTTATCTTCTATATCCTTGGC TTAGGGATTCACGGCATTGGTGGAATTGTCCGGGGTCAAACAGAGGAGAGCATGAATGAG AGTCATCCTCGCAAGTGTGCAGAGTCTTTTGAGATGTGGGATGATCGTGACTCCCACTGT AGGCGCCCTAAGTTTGAAGGGCATCCCCCTGAGTCTTGGAAGTGGATCCTTGCACCGGTC ATTCTTTATATCTGTGAAAGGATCCTCCGGTTTTACCGCTCCCAGCAGAAGGTTGTGATT ACCAAGGTTGTTATGCACCCATCCAAAGTTTTGGAATTGCAGATGAACAAGCGTGGCTTC AGCATGGAAGTGGGGCAGTATATCTTTGTTAATTGCCCCTCAATCTCTCTCCTGGAATGG CATCCTTTTACTTTGACCTCTGCTCCAGAGGAAGATTTCTTCTCCATTCATATCCGAGCA GCAGGGGACTGGACAGAAAATCTCATAAGGGCTTTCGAACAACAATATTCACCAATTCCC AGGATTGAAGTGGATGGTCCCTTTGGCACAGCCAGTGAGGATGTTTTCCAGTATGAAGTG GCTGTGCTGGTTGGAGCAGGAATTGGGGTCACCCCCTTTGCTTCTATCTTGAAATCCATC TGGTACAAATTCCAGTGTGCAGACCACAACCTCAAAACAAAAAAGATCTATTTCTACTGG ATCTGCAGGGAGACAGGTGCCTTTTCCTGGTTCAACAACCTGTTGACTTCCCTGGAACAG GAGATGGAGGAATTAGGCAAAGTGGGTTTTCTAAACTACCGTCTCTTCCTCACCGGATGG GACAGCAATATTGTTGGTCATGCAGCATTAAACTTTGACAAGGCCACTGACATCGTGACA GGTCTGAAACAGAAAACCTCCTTTGGGAGACCAATGTGGGACAATGAGTTTTCTACAATA GCTACCTCCCACCCCAAGTCTGTAGTGGGAGTTTTCTTATGTGGCCCTCGGACTTTGGCA AAGAGCCTGCGCAAATGCTGTCACCGATATTCCAGTCTGGATCCTAGAAAGGTTCAATTC TACTTCAACAAAGAAAATTTTTGA
- Chromosome Location
- X
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q9Y5S8 UniProtKB Entry Name NOX1_HUMAN HGNC ID HGNC:7889 - General References
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