Carboxypeptidase Q
Details
- Name
- Carboxypeptidase Q
- Synonyms
- 3.4.17.-
- LCH1
- Lysosomal dipeptidase
- PGCP
- Plasma glutamate carboxypeptidase
- Gene Name
- CPQ
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0009559|Carboxypeptidase Q MKFLIFAFFGGVHLLSLCSGKAICKNGISKRTFEEIKEEIASCGDVAKAIINLAVYGKAQ NRSYERLALLVDTVGPRLSGSKNLEKAIQIMYQNLQQDGLEKVHLEPVRIPHWERGEESA VMLEPRIHKIAILGLGSSIGTPPEGITAEVLVVTSFDELQRRASEARGKIVVYNQPYINY SRTVQYRTQGAVEAAKVGALASLIRSVASFSIYSPHTGIQEYQDGVPKIPTACITVEDAE MMSRMASHGIKIVIQLKMGAKTYPDTDSFNTVAEITGSKYPEQVVLVSGHLDSWDVGQGA MDDGGGAFISWEALSLIKDLGLRPKRTLRLVLWTAEEQGGVGAFQYYQLHKVNISNYSLV MESDAGTFLPTGLQFTGSEKARAIMEEVMSLLQPLNITQVLSHGEGTDINFWIQAGVPGA SLLDDLYKYFFFHHSHGDTMTVMDPKQMNVAAAVWAVVSYVVADMEEMLPRS
- Number of residues
- 472
- Molecular Weight
- 51887.185
- Theoretical pI
- Not Available
- GO Classification
- Functionscarboxypeptidase activity / metal ion binding / metallodipeptidase activity / protein homodimerization activityProcessespeptide catabolic process / proteolysis / thyroid hormone generation / tissue regenerationComponentscytoplasm / endoplasmic reticulum / extracellular exosome / extracellular space / Golgi apparatus / lysosome
- General Function
- Protein homodimerization activity
- Specific Function
- Carboxypeptidase that may play an important role in the hydrolysis of circulating peptides. Catalyzes the hydrolysis of dipeptides with unsubstituted terminals into amino acids. May play a role in the liberation of thyroxine hormone from its thyroglobulin (Tg) precursor.
- Pfam Domain Function
- Peptidase_M28 (PF04389)
- Transmembrane Regions
- Not Available
- Cellular Location
- Endoplasmic reticulum
- Gene sequence
>lcl|BSEQ0013236|Carboxypeptidase Q (CPQ) ATGAAATTCCTTATCTTCGCATTTTTCGGTGGTGTTCACCTTTTATCCCTGTGCTCTGGG AAAGCTATATGCAAGAATGGCATCTCTAAGAGGACTTTTGAAGAAATAAAAGAAGAAATA GCCAGCTGTGGAGATGTTGCTAAAGCAATCATCAACCTAGCTGTTTATGGTAAAGCCCAG AACAGATCCTATGAGCGATTGGCACTTCTGGTTGATACTGTTGGACCCAGACTGAGTGGC TCCAAGAACCTAGAAAAAGCCATCCAAATTATGTACCAAAACCTGCAGCAAGATGGGCTG GAGAAAGTTCACCTGGAGCCAGTGAGAATACCCCACTGGGAGAGGGGAGAAGAATCAGCT GTGATGCTGGAGCCAAGAATTCATAAGATAGCCATCCTGGGTCTTGGCAGCAGCATTGGG ACTCCTCCAGAAGGCATTACAGCAGAAGTTCTGGTGGTGACCTCTTTCGATGAACTGCAG AGAAGGGCCTCAGAAGCAAGAGGGAAGATTGTTGTTTATAACCAACCTTACATCAACTAC TCAAGGACGGTGCAATACCGAACGCAGGGGGCGGTGGAAGCTGCCAAGGTGGGGGCTTTG GCATCTCTCATTCGATCCGTGGCCTCCTTCTCCATCTACAGTCCTCACACAGGTATTCAG GAATACCAGGATGGCGTGCCCAAGATTCCAACAGCCTGTATTACGGTGGAAGATGCAGAA ATGATGTCAAGAATGGCTTCTCATGGGATCAAAATTGTCATTCAGCTAAAGATGGGGGCA AAGACCTACCCAGATACTGATTCCTTCAACACTGTAGCAGAGATCACTGGGAGCAAATAT CCAGAACAGGTTGTACTGGTCAGTGGACATCTGGACAGCTGGGATGTTGGGCAGGGTGCC ATGGATGATGGCGGTGGAGCCTTTATATCATGGGAAGCACTCTCACTTATTAAAGATCTT GGGCTGCGTCCAAAGAGGACTCTGCGGCTGGTGCTCTGGACTGCAGAAGAACAAGGTGGA GTTGGTGCCTTCCAGTATTATCAGTTACACAAGGTAAATATTTCCAACTACAGTCTGGTG ATGGAGTCTGACGCAGGAACCTTCTTACCCACTGGGCTGCAATTCACTGGCAGTGAAAAG GCCAGGGCCATCATGGAGGAGGTTATGAGCCTGCTGCAGCCCCTCAATATCACTCAGGTC CTGAGCCATGGAGAAGGGACAGACATCAACTTTTGGATCCAAGCTGGAGTGCCTGGAGCC AGTCTACTTGATGACTTATACAAGTATTTCTTCTTCCATCACTCCCACGGAGACACCATG ACTGTCATGGATCCAAAGCAGATGAATGTTGCTGCTGCTGTTTGGGCTGTTGTTTCTTAT GTTGTTGCAGACATGGAAGAAATGCTGCCTAGGTCCTAG
- Chromosome Location
- 8
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q9Y646 UniProtKB Entry Name CBPQ_HUMAN HGNC ID HGNC:16910 - General References
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