Reaction: Nortriptyline to 1 product
- Reaction
- Reaction type
- Not Available
- Direction
- Major circulating metabolite?
- No
- Spontaneous?
- No
- Activity
- unknown
- References
- Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [Article]
- Amitriptyline and Nortriptyline pathway [Link]
- Roles of polymorphic enzymes CYP2D6 and CYP2C19 for in vitro metabolism of amitriptyline at therapeutic and toxic levels [Link]
- Comments
- Not Available
- Enzymes
Enzyme Km Vmax Role Cytochrome P450 2D6 Not Available Not Available confirmed Cytochrome P450 1A2 Not Available Not Available confirmed Cytochrome P450 2C19 Not Available Not Available implied