Bromfenac sodiumProduct ingredient for Bromfenac
- Name
- Bromfenac sodium
- Drug Entry
- Bromfenac
Bromfenac is a nonsteroidal anti-inflammatory drug (NSAID) for ophthalmic use. Ophthalmic NSAIDs are becoming a cornerstone for the management of ocular pain and inflammation. Their well-characterized anti-inflammatory activity, analgesic property, and established safety record have also made NSAIDs an important tool for optimizing surgical outcomes. Non-ophthalmic formulations of bromfenac were withdrawn in the US in 1998 due to cases of severe liver toxicity.2,1
- Accession Number
- DBSALT000356
- Structure
- Synonyms
- Bromfenac monosodium salt sesquihydrate / Bromfenac sodium / Bromfenac sodium hydrate / Bromfenac sodium sesquihydrate
- External IDs
- AHR-10282B
- UNII
- 8ECV571Y37
- CAS Number
- 120638-55-3
- Weight
- Average: 766.339
Monoisotopic: 763.995695148 - Chemical Formula
- C30H28Br2N2Na2O9
- InChI Key
- PPOSVVJOVKVBPW-UHFFFAOYSA-L
- InChI
- InChI=1S/2C15H12BrNO3.2Na.3H2O/c2*16-11-6-4-9(5-7-11)15(20)12-3-1-2-10(14(12)17)8-13(18)19;;;;;/h2*1-7H,8,17H2,(H,18,19);;;3*1H2/q;;2*+1;;;/p-2
- IUPAC Name
- disodium bis(2-[2-amino-3-(4-bromobenzoyl)phenyl]acetate) trihydrate
- SMILES
- O.O.O.[Na+].[Na+].NC1=C(CC([O-])=O)C=CC=C1C(=O)C1=CC=C(Br)C=C1.NC1=C(CC([O-])=O)C=CC=C1C(=O)C1=CC=C(Br)C=C1
- External Links
- PubChem Compound
- 11954316
- ChemSpider
- 10128611
- ChEBI
- 59176
- ChEMBL
- CHEMBL3181947
- Predicted Properties
Property Value Source Water Solubility 0.0118 mg/mL ALOGPS logP 3.48 ALOGPS logP 3.66 Chemaxon logS -4.5 ALOGPS pKa (Strongest Acidic) 3.81 Chemaxon pKa (Strongest Basic) 1.59 Chemaxon Physiological Charge -1 Chemaxon Hydrogen Acceptor Count 4 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 83.22 Å2 Chemaxon Rotatable Bond Count 8 Chemaxon Refractivity 91.1 m3·mol-1 Chemaxon Polarizability 29.47 Å3 Chemaxon Number of Rings 4 Chemaxon Bioavailability 1 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule Yes Chemaxon