Memantine hydrochlorideProduct ingredient for Memantine

Name
Memantine hydrochloride
Drug Entry
Memantine

Initially approved by the FDA in 2013, memantine is an N-methyl-D-aspartate (NMDA) receptor antagonist used in the management of Alzheimer's Disease (AD). It is different from many other Alzheimer's Disease medications, as it works by a different mechanism than the cholinesterase enzyme inhibitors normally employed in the management of Alzheimer's disease 2. Memantine blocks the effects of glutamate, a neurotransmitter in the brain that leads to neuronal excitability and excessive stimulation in Alzheimer's Disease 9.

In 2010, it was estimated that 36 million people worldwide live with Alzheimer's Disease. In 2013, this number increased to 44 million. Almost doubling every 20 years, the prevalence of Alzheimer's Disease is predicted to reach 66 million by 2030 and to 115 million by 2050 13. In December 2013, the G8 dementia summit concluded that dementia should be considered a global priority with the objective of developing a cure or a disease-modifying therapy by the year 2025 10,13.

Accession Number
DBSALT000456
Structure
Synonyms
Memantine HCl
UNII
JY0WD0UA60
CAS Number
41100-52-1
Weight
Average: 215.763
Monoisotopic: 215.144077416
Chemical Formula
C12H22ClN
InChI Key
LDDHMLJTFXJGPI-UHFFFAOYSA-N
InChI
InChI=1S/C12H21N.ClH/c1-10-3-9-4-11(2,6-10)8-12(13,5-9)7-10;/h9H,3-8,13H2,1-2H3;1H
IUPAC Name
3,5-dimethyladamantan-1-amine hydrochloride
SMILES
Cl.CC12CC3CC(C)(C1)CC(N)(C3)C2
PubChem Compound
181458
ChemSpider
157849
ChEBI
64323
ChEMBL
CHEMBL1699
Wikipedia
Memantine
Predicted Properties
PropertyValueSource
Water Solubility0.0455 mg/mLALOGPS
logP3.31ALOGPS
logP2.07Chemaxon
logS-3.6ALOGPS
pKa (Strongest Basic)10.7Chemaxon
Physiological Charge1Chemaxon
Hydrogen Acceptor Count1Chemaxon
Hydrogen Donor Count1Chemaxon
Polar Surface Area26.02 Å2Chemaxon
Rotatable Bond Count0Chemaxon
Refractivity54.49 m3·mol-1Chemaxon
Polarizability21.82 Å3Chemaxon
Number of Rings3Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterYesChemaxon
Veber's RuleYesChemaxon
MDDR-like RuleNoChemaxon