Ketorolac tromethamineProduct ingredient for Ketorolac
- Name
- Ketorolac tromethamine
- Drug Entry
- Ketorolac
Ketorolac is a Non-steroidal anti-inflammatory drug (NSAID) and is commercially available as an oral tablet, injectable, nasal spray and as an ophthalmic solution.910131415
It's analgesic properties make it a useful pain management tool across many settings including postoperative pain, rheumatoid arthritis, osteoarthritis, menstrual disorders, headaches, spinal and soft tissue pain, and ankylosing spondylitis.12 Impressively, ketorolac has a similar efficacy to standard doses of morphine and meperidine making it a useful opioid sparing agent.11
- Accession Number
- DBSALT001045
- Structure
- Synonyms
- Ketorolac (+/-)-form tromethamine salt / Ketorolac trometamol
- UNII
- 4EVE5946BQ
- CAS Number
- 74103-07-4
- Weight
- Average: 376.409
Monoisotopic: 376.163436501 - Chemical Formula
- C19H24N2O6
- InChI Key
- BWHLPLXXIDYSNW-UHFFFAOYSA-N
- InChI
- InChI=1S/C15H13NO3.C4H11NO3/c17-14(10-4-2-1-3-5-10)13-7-6-12-11(15(18)19)8-9-16(12)13;5-4(1-6,2-7)3-8/h1-7,11H,8-9H2,(H,18,19);6-8H,1-3,5H2
- IUPAC Name
- 1,3-dihydroxy-2-(hydroxymethyl)propan-2-aminium 5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylate
- SMILES
- [NH3+]C(CO)(CO)CO.[O-]C(=O)C1CCN2C1=CC=C2C(=O)C1=CC=CC=C1
- External Links
- KEGG Drug
- D00813
- ChemSpider
- 75795
- ChEBI
- 6130
- ChEMBL
- CHEMBL1201124
- Wikipedia
- Ketorolac
- Predicted Properties
Property Value Source Water Solubility 0.861 mg/mL ALOGPS logP -0.92 ALOGPS logP 2.28 Chemaxon logS -2.6 ALOGPS pKa (Strongest Acidic) 3.84 Chemaxon pKa (Strongest Basic) -7.8 Chemaxon Physiological Charge -1 Chemaxon Hydrogen Acceptor Count 3 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 62.13 Å2 Chemaxon Rotatable Bond Count 6 Chemaxon Refractivity 81.03 m3·mol-1 Chemaxon Polarizability 26.42 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule Yes Chemaxon