Tacrine HydrochlorideProduct ingredient for Tacrine
- Name
- Tacrine Hydrochloride
- Drug Entry
- Tacrine
A centerally active cholinesterase inhibitor that has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. Tacrine has been discontinued for the United States market.
- Accession Number
- DBSALT001053
- Structure
- Synonyms
- Tacrine HCl
- UNII
- 4966RNG0BU
- CAS Number
- 1684-40-8
- Weight
- Average: 234.73
Monoisotopic: 234.0923762 - Chemical Formula
- C13H15ClN2
- InChI Key
- ZUFVXZVXEJHHBN-UHFFFAOYSA-N
- InChI
- InChI=1S/C13H14N2.ClH/c14-13-9-5-1-3-7-11(9)15-12-8-4-2-6-10(12)13;/h1,3,5,7H,2,4,6,8H2,(H2,14,15);1H
- IUPAC Name
- 1,2,3,4,9,10-hexahydroacridin-9-imine hydrochloride
- SMILES
- Cl.N=C1C2=C(CCCC2)NC2=CC=CC=C12
- External Links
- ChemSpider
- 14764
- ChEMBL
- CHEMBL1677
- Wikipedia
- Tacrine
- Predicted Properties
Property Value Source Water Solubility 0.135 mg/mL ALOGPS logP 2.39 ALOGPS logP 2.41 Chemaxon logS -3.2 ALOGPS pKa (Strongest Acidic) 15.91 Chemaxon pKa (Strongest Basic) 12.41 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 2 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 35.88 Å2 Chemaxon Rotatable Bond Count 0 Chemaxon Refractivity 74.99 m3·mol-1 Chemaxon Polarizability 22.73 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon