Bepridil hydrochlorideProduct ingredient for Bepridil
- Name
- Bepridil hydrochloride
- Drug Entry
- Bepridil
A long-acting, non selective, calcium channel blocker with significant anti-anginal activity. The drug produces significant coronary vasodilation and modest peripheral effects. It has antihypertensive and selective anti-arrhythmia activities and acts as a calmodulin antagonist. It is no longer marketed in the United States, as it has been implicated in causing ventricular arrhythmias (ie. Torsade de pointes).
- Accession Number
- DBSALT001436
- Structure
- Synonyms
- Bepridil HCl
- UNII
- 4W2P15D93M
- CAS Number
- 74764-40-2
- Weight
- Average: 421.02
Monoisotopic: 420.2543561 - Chemical Formula
- C24H37ClN2O2
- InChI Key
- UEECHQPWQHYEDE-UHFFFAOYSA-N
- InChI
- InChI=1S/C24H34N2O.ClH.H2O/c1-21(2)19-27-20-24(25-15-9-10-16-25)18-26(23-13-7-4-8-14-23)17-22-11-5-3-6-12-22;;/h3-8,11-14,21,24H,9-10,15-20H2,1-2H3;1H;1H2
- IUPAC Name
- N-benzyl-N-[3-(2-methylpropoxy)-2-(pyrrolidin-1-yl)propyl]aniline hydrate hydrochloride
- SMILES
- O.Cl.CC(C)COCC(CN(CC1=CC=CC=C1)C1=CC=CC=C1)N1CCCC1
- External Links
- ChemSpider
- 82825
- ChEBI
- 52715
- ChEMBL
- CHEMBL1200382
- Wikipedia
- Bepridil
- Predicted Properties
Property Value Source Water Solubility 0.00655 mg/mL ALOGPS logP 5.33 ALOGPS logP 5.49 Chemaxon logS -4.8 ALOGPS pKa (Strongest Basic) 9.16 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 3 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 15.71 Å2 Chemaxon Rotatable Bond Count 10 Chemaxon Refractivity 115.12 m3·mol-1 Chemaxon Polarizability 43.79 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 1 Chemaxon Rule of Five No Chemaxon Ghose Filter Yes Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule Yes Chemaxon